Results 101 to 110 of about 74,242 (343)

Commercial Cdk1 Antibodies Recognize the Centrosomal Protein Cep152 [PDF]

BioTechniques, 2013
Reference EPFL-ARTICLE-188397doi:10.2144/000114074View record in Web of Science Record created on 2013-09-08, modified on 2016-08 ...
Lukinavicius, G., Lavogina, D., Gönczy, P., Johnsson, K.   +3 more
openaire   +3 more sources

A mei-P26 is required for initiation of meiosis in the Drosophila male germline

Cell Structure and Function
Mei-P26, a member of the TRIM-NHL family, plays a pivotal role in Drosophila germline development, including female meiosis. However, its role in male meiosis remains unclear.
Mai Oda, Yuri Tanaka, Yoshihiro H. Inoue
doaj   +1 more source

Emergent properties of the G1/S network [PDF]

, 2010
Tato práce se zabývá buněčným cyklem kvasinky Saccgaromyces cerevisiae. Oblastí našeho zájmu je přechod mezi G1 a S fází, kde je naším cílem identifikovat velikosti buňky v době počátku DNA replikace.
Dražková, Jana
core  

USP7 limits CDK1 activity throughout the cell cycle

EMBO Journal, 2021
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors also generate DNA damage in a p53‐independent manner.
A. Galarreta, P. Valledor, Patricia Ubieto-Capella, V. Lafarga, E. Zarzuela, J. Muñoz, Marcos Malumbres, E. Lecona, O. Fernández-Capetillo   +8 more
semanticscholar   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]

, 2019
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty, A Jain, AE Kelly, AG Larson, AM Ainsztein, AR Strom, B Banerjee, B Bolognesi, BG Fuller, BR Sabari, E Niedzialkowska, E Wang, Enrico Gratton, Ewa Niedzialkowska, F Cardarelli, F Sessa, F Wang, Francesco Palomba, J Chen, J Du, JB Woodruff, JG Ruppert, K Jaqaman, KM Sathyan, KS Bloom, L Scipioni, M Delacour-Larose, M Wachsmuth, M Wühr, Michelle A. Digman, ML Hanley, MS Wheelock, P Trivedi, P Trivedi, P. Todd Stukenberg, PDJ Moens, Prasad Trivedi, R Mahen, RCC Hengeveld, S Ambadipudi, S Hauf, S Hindriksen, SC Sampath, SE Rosasco-Nitcher, SF Banani, Shasha Chong, SM Janicki, SP Wheatley, T Hirota, T Tsukahara, UR Klein, VA Beardmore, W Fischle, X Liu, Y Abe, Y Shin, Y Yamagishi, Y Yamagishi   +57 more
core   +2 more sources

Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer

Journal of International Medical Research, 2021
Objective Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.
Z. Xing, Xin Wang, Jiaqi Liu, Menglu Zhang, K. Feng, Xiang Wang   +5 more
semanticscholar   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Phosphorylation of the androgen receptor at Ser81 is co‐sustained by CDK1 and CDK9 and leads to AR‐mediated transactivation in prostate cancer

Molecular Oncology, 2021
Androgen receptor (AR) is the principal molecule in prostate cancer (PCa) etiology and therapy. AR re‐activation still remains a major challenge during treatment of castration‐resistant prostate cancer (CRPC) tumors that relapse after castration ...
Xintao Gao, Jiaqian Liang, Liyang Wang, Zhaoyang Zhang, Penghui Yuan, Jiaxin Wang, Yanfei Gao, Fen Ma, Carla Calagua, Huihui Ye, O. Voznesensky, Shaogang Wang, Tao Wang, Jihong Liu, Shaoyong Chen, Xiaming Liu   +15 more
semanticscholar   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source