Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase [PDF]
Cells, 2020 Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are ...
Jaroslav Kalous +2 more
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Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds [PDF]
Frontiers in Chemistry, 2022 Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of ...
Lanlan Fu +4 more
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Cyclin‐dependent kinase 1 shows to be a potential genetic target for chemical cystitis [PDF]
Immunity, Inflammation and Disease, 2021 Background In the present study, we aimed to explore whether common genetic targets or signaling pathways existed in chemical cystitis. Methods Gene Expression Omnibus (GEO) database was used to search the related gene expression profiles.
Kun Wang +5 more
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Overexpression of cyclin‐dependent kinase 1 in esophageal squamous cell carcinoma and its clinical significance [PDF]
FEBS Open Bio, 2021 Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC).
Han‐Jie Zhang +8 more
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Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor. [PDF]
PLoS Biology, 2021 Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division.
Christina D Cota +5 more
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Cells, 2023 The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
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Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1
Molecular & Cellular Oncology, 2021 Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
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Acta Pharmaceutica Sinica B, 2022 Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this ...
Sha-Sha Cheng +12 more
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A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Plant Direct, 2023 Meiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes.
Sorin Tanasa +10 more
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CAPTURE of the Human U2 snRNA Genes Expands the Repertoire of Associated Factors
Biomolecules, 2022 In order to identify factors involved in transcription of human snRNA genes and 3′ end processing of the transcripts, we have carried out CRISPR affinity purification in situ of regulatory elements (CAPTURE), which is deadCas9-mediated pull-down, of the ...
Joana Guiro +6 more
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