Results 41 to 50 of about 109,030,997 (289)

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1 [PDF]

, 2012
P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported.
Perearnau Garcia, Anna, Bachs Valldeneu, Oriol, Martínez-Balbás, Marian, Pérez-Luna, Maria, Serratosa i Serdà, Joan, Aguasca, M., Bachs, Oriol, Serratosa, Joan, Martínez Balbás, Marian, Aguasca i Marsà, Marta, Pujol Sobrevía, María Jesús, Pujol, María Jesús, Perearnau, Anna   +12 more
core   +1 more source

Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis [PDF]

Molecular and Cellular Biology, 2012
Cyclin-dependent kinase 16 (CDK16, PCTK1) is a poorly characterized protein kinase, highly expressed in the testis and the brain. Here, we report that CDK16 is activated by membrane-associated cyclin Y (CCNY). Treatment of transfected human cells with the protein kinase A (PKA) activator forskolin blocked, while kinase inhibition promoted, CCNY ...
Mikolcevic, P., Sigl, R., Rauch, V., Hess, M., Pfaller, K., Barisic, M., Pelliniemi, L., Boesl, M., Geley, S.   +8 more
openaire   +5 more sources

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

Journal of Medicinal Chemistry, 2008
Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key molecular features of Alzheimer's disease, production of amyloid-beta peptides (extracellular plaques) and hyper-phosphorylation of Tau (intracellular neurofibrillary tangles).
Oumata, Nassima, Bettayeb, Karima, Ferandin, Yoan, Demange, Luc, Lopez-Giral, Angela, Goddard, Marie-Lore?ne, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Flajolet, Marc, Greengard, Paul, Meijer, Laurent, Galons, Herve?   +11 more
openaire   +3 more sources

Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase [PDF]

Science, 2016
Phosphorylation cues exit from mitosis The entry and exit from the cell cycle are controlled by waves of protein phosphorylation and degradation events. Fujimitsu et al. describe the precise mechanism by which the cell cycle machinery controls exit from mitosis. The critical
Fujimitsu, K, Grimaldi, M, Yamano, H
openaire   +3 more sources

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Turner Nicholas J., Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Blake, D.G., Malcolm D Walkinshaw, Thomson, G.   +48 more
core   +2 more sources

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific Reports, 2023
p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs.
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina   +8 more
doaj   +1 more source

Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]

, 1995
Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J., Lindsay, Howard D., Ford, Christopher C.   +2 more
core   +3 more sources

Anti-Cancer Potential of Oxialis obtriangulata in Pancreatic Cancer Cell through Regulation of the ERK/Src/STAT3-Mediated Pathway

Molecules, 2020
As a plant medicine, Oxalidaceae has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of Oxalidaceae, particularly O. obtriangulata.
Eun-Jin An, Yumi Kim, Seung-Hyeon Lee, Hyun Min Ko, Won-Seok Chung, Hyeung-Jin Jang   +5 more
doaj   +1 more source

Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1

Scientific Reports, 2021
S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu, Xiao-Jing Li, Moges Dessale Asmamaw, Xiaa-Jing Shi, Hong-Min Liu   +4 more
doaj   +1 more source

Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases. [PDF]

Proceedings of the National Academy of Sciences, 1994
Protein phosphatase 1 and protein phosphatase 2A contain potential phosphorylation sites for cyclin-dependent kinases. In the present study we found that rabbit skeletal muscle protein phosphatase 1, as well as recombinant protein phosphatase 1 alpha and protein phosphatase 1 gamma 1, but not protein phosphatase 2A, was phosphorylated and inhibited by ...
M, Dohadwala, E F, da Cruz e Silva, F L, Hall, R T, Williams, D A, Carbonaro-Hall, A C, Nairn, P, Greengard, N, Berndt   +7 more
openaire   +2 more sources