Results 51 to 60 of about 109,030,997 (289)

Anti-proliferation Effect on Human Breast Cancer Cells Inhibition of pRb Phosphorylation by Taiwanin E Isolated from

Natural Product Communications, 2014
Eleutherococcus trifoliatus has been used as a folk medicine since ancient times, especially as refreshing qi medicines. In our current study, taiwanin E, which possesses strong cytotoxicity, was isolated from the branches of E.
Hui-Chun Wang, Yen-Hsueh Tseng, Hui-Rong Wu, Fang-Hua Chu, Yueh-Hsiung Kuo, Sheng-Yang Wang   +5 more
doaj   +1 more source

Wound Healing Potential of Spirulina Protein on CCD-986sk Cells

Marine Drugs, 2019
Wound healing is a dynamic and complex process. The proliferation and migration of dermal fibroblasts are crucial for wound healing. Recent studies have indicated that the extracts from Spirulina platensis have a positive potential for wound healing ...
Ping Liu, Jeong-Wook Choi, Min-Kyeong Lee, Youn-Hee Choi, Taek-Jeong Nam   +4 more
doaj   +1 more source

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
Sarkar, S. (Sourav), Sourav Sarkar, Novák, Béla, Tibbles, Katherine L., Prakash Arumugam, Arumugam P., Bela Novak (5648875), Sarkar S., Arumugam Prakash, Arumugam, Prakash, Sourav Sarkar (430861), Katherine Louise Tibbles (478963), Katherine Louise Tibbles, Bela Novak, Sarkar Sourav, Novak Bela, Tibbles Katherine Louise, Prakash Arumugam (303310), Tibbles K.L., Novak B.   +19 more
core   +2 more sources

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

PLoS ONE, 2007
M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis.
Vincenzo D'Angiolella, Luca Palazzo, Concetta Santarpia, Vincenzo Costanzo, Domenico Grieco   +4 more
doaj   +1 more source

The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer [PDF]

, 2012
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients.
Madhuri, K, Giannopoulos, T, P Chivers, D P Lovell, Crook, T, H M Coley, E Papacharalbous, T Giannopoulos, Coley, HM, Butler-Manuel, S, S Butler-Manuel, K Madhuri, Papacharalbous, E, Lovell, DP, N A M Safuwan, Safuwan, NA, T Crook, Chivers, P   +17 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways. [PDF]

PLoS ONE, 2018
The present study was designed to investigate the pathways involved in the effect of betel nut arecoline on cell viability in 3T3-L1 preadipocytes. Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time ...
Zi-Han Tian, Jueng-Tsueng Weng, Li-Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei, Yow-Chii Kuo, Tsu-Shing Wang, Yung-Hsi Kao   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cyclin-Dependent Kinase 5 and Insulin Secretion

, 2008
Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells.
Marko Jevsek, Jevsek, Marko, Slavena A. Mandic, Marjan Rupnik, Christina Bark, Bark, Christina, Berggren, Per-Olof, Mandic, Slavena A., Rupnik, Marjan, Per-Olof Berggren   +9 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source