Results 31 to 40 of about 109,030,997 (289)

Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway

Frontiers in Pharmacology, 2023
Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring.
Yuxiao Wan, Ziyi Wu, Xingyue Li, Ping Zhao   +3 more
doaj   +1 more source

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Popp, Oliver, Nalabothula, Narasimharao, Machleidt, Werner, Ghosh, Madhumita, Gil-Parrado, Shirley, Holak, Tad A., Joy, Joma, Jochum, Marianne   +7 more
core   +1 more source

Cyclin-dependent kinases as therapeutic targets for HIV-1 infection [PDF]

Expert Opinion on Therapeutic Targets, 2016
A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure strategies involve the development of small molecules that are able to activate HIV-1 from latent infection, thereby ...
openaire   +2 more sources

Polo-like kinase 1 inhibits the activity of positive transcription elongation factor of RNA Pol II b (P-TEFb).

PLoS ONE, 2013
Polo-like kinase 1 (Plk1) is a highly conserved Ser/Thr kinase in eukaryotes and plays a critical role in various aspects of the cell cycle. Plk1 exerts its multiple functions by phosphorylating its substrates.
Liangzhen Jiang, Yan Huang, Min Deng, Ting Liu, Wenbin Lai, Xin Ye   +5 more
doaj   +1 more source

Regulation of Protein Phosphatase Inhibitor-1 by Cyclin-dependent Kinase 5 [PDF]

Journal of Biological Chemistry, 2007
Inhibitor-1, the first identified endogenous inhibitor of protein phosphatase 1 (PP-1), was previously reported to be a substrate for cyclin-dependent kinase 5 (Cdk5) at Ser67. Further investigation has revealed the presence of an additional Cdk5 site identified by mass spectrometry and confirmed by site-directed mutagenesis as Ser6.
Chan, Nguyen, Akinori, Nishi, Janice W, Kansy, Joseph, Fernandez, Kanehiro, Hayashi, Frank, Gillardon, Hugh C, Hemmings, Angus C, Nairn, James A, Bibb   +8 more
openaire   +2 more sources

Mitotic Regulation of SIRT2 by Cyclin-dependent Kinase 1-dependent Phosphorylation [PDF]

Journal of Biological Chemistry, 2007
Sirtuins are evolutionarily conserved NAD(+)-dependent deacetylases and ADP-ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair, genomic silencing, and longevity. Recent studies have focused on identifying target substrates for human sirtuin enzymatic activity, but little is known about processes that directly ...
Brian J, North, Eric, Verdin
openaire   +2 more sources

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism of proteasome inhibition in endometrial cancer is not very clear.
Yuanyuan Zhou, Ke Wang, Shuai Zhen, Ruili Wang, Wenjuan Luo   +4 more
doaj   +1 more source

Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors [PDF]

Proceedings of the National Academy of Sciences, 2001
Cyclin-dependent kinase 5 (Cdk5) is a multifunctional neuronal protein kinase that is required for neurite outgrowth and cortical lamination and that plays an important role in dopaminergic signaling in the neostriatum through phosphorylation of Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, molecular mass 32 ...
F, Liu, X H, Ma, J, Ule, J A, Bibb, A, Nishi, A J, DeMaggio, Z, Yan, A C, Nairn, P, Greengard   +8 more
openaire   +2 more sources

CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]

PLoS ONE, 2011
C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu, Lifeng Liu, Xueshan Qiu, Lili Jiang, Bo Huang, Haiying Li, Zixuan Li, Wenting Luo, Enhua Wang   +8 more
doaj   +1 more source

Effect of ECT2 Gene on Proliferation of Cervical Cancer Cells and Its Mechanism

Zhongliu Fangzhi Yanjiu, 2022
Objective To study the effect of epithelial cell transformation sequence 2 (ECT2) on the proliferation of cervical cancer cells and its mechanism. Methods We transfected cervical cancer cells HeLa (HeLa-ECT2) with the lentivirus overexpressing ECT2 and ...
CHEN Yu, SONG Ziye, GAO Yang, CAI Hongbing   +3 more
doaj   +1 more source