CDKN1B (cyclin-dependent kinase inhibitor 1 B ) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 1998 Review on CDKN1B (cyclin-dependent kinase inhibitor 1 B ), with data on DNA, on the protein encoded, and where the gene is ...
Bilhou-Nabera, C, C Bilhou-Nabera
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The Cyclin-dependent kinase 1: more than a cell cycle regulator. [PDF]
Br J Cancer, 2023 AbstractThe Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. During the last decade, it has been shown to carry out versatile functions during the last decade. From cell cycle control to gene expression regulation and apoptosis, CDK1 is intimately involved in many ...
Massacci G, Perfetto L, Sacco F.
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Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. [PDF]
J Biol Chem, 2021 Abstract Talin is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behaviour of its multiple rod domains that modulate interactions with its binding partners.
Gough RE +11 more
europepmc +9 more sources
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1). [PDF]
Cancers (Basel), 2022 Cyclin-dependent kinase 1 (CDK1) is essential for cell division by regulating the G2/M phase and mitosis. CDK1 overexpression can also promote the development and progression of a variety of cancers. However, the significance of CDK1 in the formation, progression, and prognosis of human pan-cancer remains unclear.
Liu X, Wu H, Liu Z.
europepmc +3 more sources
Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E +3 more
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The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]
, 2011 Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha +2 more
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Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses [PDF]
Proceedings of the National Academy of Sciences, 2004 Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting ...
Sang Yoon, Lee +4 more
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The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development. [PDF]
Sci Rep, 2016 AbstractSkeletal development is tightly regulated through the processes of chondrocyte proliferation and differentiation. Although the involvement of transcription and growth factors on the regulation of skeletal development has been extensively studied, the role of cell cycle regulatory proteins in this process remains elusive.
Saito M +6 more
europepmc +4 more sources
Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation. [PDF]
Oncotarget, 2016 The multifunctional protein p21Cip1/CDKN1A (p21) is an important and universal Cdk-interacting protein. Recently, we have reported that p21 is involved in the regulation of the mitotic kinase Cdk1/cyclin B1 and critical for successful mitosis and cytokinesis.
Kreis NN +7 more
europepmc +5 more sources
Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]
, 2011 Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Mayer, Bettina A. +23 more
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