Results 61 to 70 of about 109,030,997 (289)

p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein [PDF]

Molecular and Cellular Biology, 2000
Regulated cyclin-dependent kinase (CDK) levels and activities are critical for the proper progression of the cell division cycle. p12(DOC-1) is a growth suppressor isolated from normal keratinocytes. We report that p12(DOC-1) associates with CDK2.
S, Shintani, H, Ohyama, X, Zhang, J, McBride, K, Matsuo, T, Tsuji, M G, Hu, G, Hu, Y, Kohno, M, Lerman, R, Todd, D T, Wong   +11 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol [PDF]

, 2008
Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Androic, Ilija, Yuan Juping, Strebhardt Klaus, Yan Ruilan, Yan, Ruilan, Gätje Regine, Krämer, Andrea, Gätje, Regine, Androic Ilija, Andrea Krämer, Rödel, Franz, Yuan, Juping, Krämer Andrea, Ilija Androic, Manfred Kaufmann, Ruilan Yan, Klaus Strebhardt, Rödel Franz, Strebhardt, Klaus, Juping Yuan, Kaufmann Manfred, Franz Rödel, Regine Gätje, Kaufmann, Manfred   +23 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Inhibitory Phosphorylation of Cyclin-Dependent Kinase 1 as a Compensatory Mechanism for Mitosis Exit [PDF]

Molecular and Cellular Biology, 2011
The current paradigm states that exit from mitosis is triggered by the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) acting in concert with an activator called CDC20. While this has been well established for a number of systems, the evidence of a critical role of CDC20 in somatic cells is not unequivocal.
Chow, Jeremy Pak Hong, Poon, Randy Yat Choi, Ma, Hoi Tang   +2 more
openaire   +3 more sources

Phosphoproteome Remodeling upon CDK1 Inhibition Restricts HSV-1 IE Gene Transcription and Replication

Cells
Cyclin-dependent kinase 1 (CDK1) regulates multiple cellular processes that HSV-1 can exploit to promote its own replication, particularly during the early steps of lytic infection.
Maxim S. Rodzkin, Drew R. Honeycutt, David J. Davido   +2 more
doaj   +1 more source

Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

Cell Death and Disease, 2023
Esophageal squamous cell carcinoma (ESCC) is an upper gastrointestinal cancer with high morbidity and mortality. New strategies are urgently needed to prolong patients’ survival.
Xinning Liu, Yanan Jiang, Hao Zhou, Xiaokun Zhao, Mingzhu Li, Zhuo Bao, Zitong Wang, Chenyang Zhang, Zhenliang Xie, Jimin Zhao, Zigang Dong, Kangdong Liu, Zhiping Guo   +12 more
doaj   +1 more source

CENP-C Phosphorylation by CDK1 in vitro

Bio-Protocol, 2021
Accurate chromosome segregation during mitosis requires the kinetochore, a large protein complex, which makes a linkage between chromosomes and spindle microtubes. An essential kinetochore component, CENP-C, is phosphorylated by Cyclin-B-Cyclin dependent
Reito Watanabe, Masatoshi Hara, Mariko Ariyoshi, Tatsuo Fukagawa   +3 more
doaj   +1 more source

Spy1-activated Cyclin Dependent Kinase 2 Shows Reduced Affinity for Current Synthetic Small Molecule Inhibitors of the CDK2-Cyclin Complex [PDF]

, 2023
Cyclin-dependent kinases (CDKs) play a key role in activating essential cell biology processes including cellular proliferation. Inappropriate regulation of CDKs has been implicated in driving several different forms of cancer.
John, Hayward, Bre-Anne, Fifield, Lisa, Porter, Daniel, Meister, John, Trant, Bre‐Anne Fifield, John J. Hayward, Lisa A. Porter, Daniel Meister, John F. Trant   +9 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source