Results 91 to 100 of about 74,242 (343)

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]

PLoS ONE, 2012
Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su, Tsunghan Yang, Hoting Huang, Leroy F Liu, Jaulang Hwang   +4 more
doaj   +1 more source

LncRNAs: the bridge linking RNA and colorectal cancer. [PDF]

, 2016
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control ...
Chen, Yi, Deng, Xiangbing, Feng, Min, Lau, Bonnie, Lau, Wayne Bond, Le, Xiaobing, Lei, Lingzi, Luo, Zhongyue, Wang, Chenlu, Wei, Yuquan, Xu, Lian, Xuan, Yu, Yang, Huiliang, Yang, Qilian, Yang, Yanfei, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Shengtao   +18 more
core   +4 more sources

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma [PDF]

, 2019
Circular RNAs (circRNAs) represent a class of covalently closed RNAs, derived from non-canonical splicing events, which are expressed in all eukaryotes and often conserved among different species.
Bozzoni, Irene, Colantoni, Alessio, Dattilo, Dario, DI TIMOTEO, Gaia, Dominici, Carlo, Legnini, Ivano, Megiorni, Francesca, Morlando, Mariangela, Rossi, Francesca, Santini, Tiziana   +9 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients [PDF]

, 2018
Currently, there are no valid pre-operatively established biomarkers or algorithms that can accurately predict surgical and clinical outcome for patients with advanced epithelial ovarian cancer (EOC).
Boutelle, Martyn G., Cunnea, Paula, Curry, Ed, Domenici, Lavinia, Drakakis, Emmanuel M., Fotopoulou, Christina, Gabra, Hani, Gorgy, Tommy, Gowers, Sally A. N., Lawton, Phillip, Leng Leong, Chi, Lu, Haonan, Morera, Cristina, Nixon, Katherine, Paterson, Andrew, Petkos, Konstantinos, Sorbi, Flavia, Wu, Wen   +17 more
core   +2 more sources

BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

Molecules and Cells, 2020
Summary Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and mitotic checkpoint signaling.
Priyanka Singh, M. Pesenti, S. Maffini, S. Carmignani, Marius Hedtfeld, Arsen Petrovic, Anupallavi Srinivasamani, Tanja Bange, A. Musacchio   +8 more
semanticscholar   +1 more source

Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors

Cancer Research, 2021
These findings propose CDK1 as a novel cell-cycle–independent vulnerability in gastrointestinal stromal tumors, representing a new therapeutic opportunity for patients with advanced disease.
Xiaojing Lu, Yuzhi Pang, H. Cao, Xiaoxiao Liu, L. Tu, Yanying Shen, X. Jia, Jen-Chieh Lee, Yuexiang Wang   +8 more
semanticscholar   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Cdk1-dependent control of membrane-trafficking dynamics

Molecular Biology of the Cell, 2012
Cyclin-dependent kinase 1 (Cdk1) is required for initiation and maintenance of polarized cell growth in budding yeast. Cdk1 activates Rho-family GTPases, which polarize the actin cytoskeleton for delivery of membrane to growth sites via the secretory pathway.
McCusker D, Royou A, Velours C, Kellogg D.   +3 more
openaire   +3 more sources