Results 51 to 60 of about 74,242 (343)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]

, 2014
Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian, Musgrove, Elizabeth A., Sergio, C. Marcelo, Sutherland, Robert L.   +3 more
core   +2 more sources

Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer.

European journal of medicinal chemistry, 2022
Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a promising strategy to combat several human malignancies. CDK1 is an example of such a valuable target for the management of pancreatic ductal adenocarcinomas (PDAC); its
Laila Akl, A. A. Abd El‐Hafeez, Tamer M. Ibrahim, Rofaida Salem, Hala Mohamed M. Marzouk, Ramadan A. El-domany, P. Ghosh, Wagdy M. Eldehna, S. M. Abou-Seri   +8 more
semanticscholar   +1 more source

Dissection of Cdk1–cyclin complexes in vivo [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance A simple strategy is described to discover cyclin dependency of general cell cycle regulatory kinase cyclin-dependent kinase 1 for substrates in vivo. γ-Tubulin is discovered to be a specific B cyclin Clb3–cyclin-dependent kinase 1 substrate.
Po Hien, Ear, Michael J, Booth, Diala, Abd-Rabbo, Jacqueline, Kowarzyk Moreno, Conrad, Hall, Daici, Chen, Jackie, Vogel, Stephen W, Michnick   +7 more
openaire   +2 more sources

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors [PDF]

, 2015
Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of ...
Eggert, Angelika, Koester, Johannes, Lee, Sangkyun, Morik, Katharina, Schramm, Alexander, Schulte, Johannes H, Schwermer, Melanie, Stephan, Harald, Van Maerken, Tom   +8 more
core   +2 more sources

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

Cell Discovery, 2020
The cyclic GMP-AMP synthase (cGAS) is a widely used DNA sensor, which detects cytosolic DNA species without a preference of self or non-self microbial DNA in interphase to initiate innate immune response.
Li Zhong, Ming-Ming Hu, Li-Jun Bian, Y. Liu, Qiang Chen, H. Shu   +5 more
semanticscholar   +1 more source

Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation

bioRxiv, 2022
Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear.
Aymen Al-Rawi, S. Korolchuk, J. Endicott, T. Ly   +3 more
semanticscholar   +1 more source

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy [PDF]

, 2017
Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial.
Al-Azzawi, Balk, Baniahmad, Buchanan, Christiansen, Christiansen, Denmeade, Dlewati, Festuccia, Festuccia, Festuccia, Gailly, Hayes, Hellstrom, Huang, Isaacs, Isaacs, Isaacs, Isaacs, Jannini, Key, Liu, Maggi, Morgentaler, Morgentaler, Mostaghel, Neidle, Pagano, Pagano, Page, Page, Pandolfi, Park, Paschal, Pestell, Pitha, Roussel, Schneider, Sonnenschein, Soto, Strauss, Swerdloff, Traish, Vogelzang, Wilson, Yen, Zi   +46 more
core   +1 more source

Systematic Pan-Cancer Analysis Identifies CDK1 as an Immunological and Prognostic Biomarker

Journal of Oncology, 2022
Cyclin-dependent kinase 1 (CDK1) plays an important role in cancer development, progression, and the overall process of tumorigenesis. However, no pan-cancer analysis has been reported for CDK1, and the predictive role of CDK1 in immune checkpoint ...
Yaqi Yang, Qin Liu, Xiyuan Guo, Qing Yuan, Siji Nian, Peng-peng Kang, Zixi Xu, Lin Li, Y. Ye   +8 more
semanticscholar   +1 more source

Cdk1 and SUMO Regulate Swe1 Stability

PLoS ONE, 2010
The Swe1/Wee1 kinase phosphorylates and inhibits Cdk1-Clb2 and is a major mitotic switch. Swe1 levels are controlled by ubiquitin mediated degradation, which is regulated by interactions with various mitotic kinases. We have recently reported that Swe1 levels are capable of sensing the progress of the cell cycle by measuring the levels of Cdk1-Clb2 ...
Kobi J Simpson-Lavy, Michael Brandeis
openaire   +4 more sources

Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification. [PDF]

, 2016
Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice.
Cao, Yan, Chai, Yifeng, Chen, Xiaofei, Dan, Jia, Diao, Yong, Gao, Shouhong, Guo, Zhiying, Wu, Xunxun, Zerbe, Philipp, Zhang, Lei   +9 more
core   +1 more source