Results 31 to 40 of about 46,551 (257)
Caractérisation du rôle de Cdk1 dans le développement de neurones nouveaux-nés du cerveau adulte [PDF]
, 2023 In mammals, the hippocampus is one of the few sites which produce new neurons throughout life. This process, known as adult hippocampal neurogenesis (AHN), takes place in the dentate gyrus (DG) and corresponds to a sequence of cellular events undergone ...
Marlier, Quentin +4 more
core +1 more source
Ultrasensitivity in the Regulation of Cdc25C by Cdk1 [PDF]
Molecular Cell, 2011 Cdc25C is a critical component of the interlinked positive and double-negative feedback loops that constitute the bistable mitotic trigger. Computational studies have indicated that the trigger's bistability should be more robust if the individual legs of the loops exhibit ultrasensitive responses. Here, we show that in Xenopus extracts two measures of
Trunnell, Nicole B. +3 more
openaire +2 more sources
CDK1, the Other ‘Master Regulator’ of Autophagy [PDF]
Trends in Cell Biology, 2021 Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies ...
Richard I, Odle +3 more
openaire +2 more sources
CARM1 S217 phosphorylation by CDK1 in late G2 phase facilitates mitotic entry
Cell Death and DiseaseThe coactivator-associated arginine methyltransferase 1 (CARM1) functions as an epigenetic writer, however, its role in mitosis remains poorly understood.
Yena Cho +3 more
doaj +2 more sources
Journal of Biological Chemistry, 2023 Cyclin A and CDC25A are both activators of cyclin-dependent kinases (CDKs): cyclin A acts as an activating subunit of CDKs and CDC25A a phosphatase of the inhibitory phosphorylation sites of the CDKs. In this study, we uncovered an inverse relationship between the two CDK activators.
Lau Yan Ng, Hoi Tang Ma, Randy Y.C. Poon
openaire +3 more sources
When CDK1 Rides the Telomere Cycle [PDF]
Molecular Cell, 2006 Reconstitution of telomeric DNA at each cell division implies the coordination of DNA semiconservative replication with several processing events still poorly understood. Two reports published recently in Molecular Cell show that a cell-cycle cyclin-dependent kinase, Cdk1p, is required to create the cell-cycle-regulated overhang ().
Teixeira, Maria Teresa, Gilson, Eric
openaire +3 more sources
Targeting CDK1 in cancer: mechanisms and implications
npj Precision Oncology, 2023 AbstractCyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression. Most CDKs demonstrate substantially higher expression in cancer tissues compared with normal tissues and, according to the TCGA ...
Qiushi Wang, Ann M. Bode, Tianshun Zhang
openaire +3 more sources
Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]
PLoS Biology, 2007 Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist +3 more
doaj +1 more source
Cell & Bioscience, 2023 Background Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in ...
Xiaodong Xu +9 more
doaj +1 more source
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Vázquez-Novelle, María Dolores +6 more
core +1 more source