Results 11 to 20 of about 46,551 (257)
Compartmentalized control of Cdk1 drives mitotic spindle assembly [PDF]
Cell Reports, 2022 Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle.
Angela Flavia Serpico +3 more
doaj +2 more sources
Cell Reports, 2023 Summary: Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide.
Julio Poveda, Tianling Hu, Longlong Cao
exaly +3 more sources
Multi-omics profiling identifies CDK1 as a key mediator of mitosis through the PTN pathway in bladder cancer [PDF]
Future Science OAAims This study aimed to characterize cyclin-dependent kinase 1 (CDK1) expression in bladder cancer (BC), elucidate its role in intercellular signaling and mitosis, and identify small-molecule inhibitors targeting CDK1.Methods RNA sequencing data from ...
Li Yang +10 more
doaj +2 more sources
CDK1 serves as a potential prognostic biomarker and target for lung cancer
Journal of International Medical Research, 2020 Objective Evidence from cell and mouse models and human tissues suggests that cyclin dependent kinase 1 (CDK1) is involved in lung cancer (LC) tumorigenesis.
Fenyi He, Mingyao Li
exaly +2 more sources
Copper is essential for cyclin B1-mediated CDK1 activation
Nature CommunicationsCyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1.
Jiaru Wang +12 more
doaj +2 more sources
Cdk1 and SUMO regulate Swe1 stability. [PDF]
PLoS ONE, 2010 The Swe1/Wee1 kinase phosphorylates and inhibits Cdk1-Clb2 and is a major mitotic switch. Swe1 levels are controlled by ubiquitin mediated degradation, which is regulated by interactions with various mitotic kinases.
Simpson-Lavy Kobi J. +4 more
core +5 more sources
An Integrated Cellular Computational Pipeline Decodes Luteolin to Design Possible Allosteric CDK1/CYCLIN B1 Inhibitors That Overcome Breast Cancer Stemness [PDF]
PharmaceuticalsBackground: The dysregulation of the CDK1/Cyclin B1 complex drives tumor progression in breast cancer (BC). The natural flavonoid luteolin (LT) shows anti-cancer potential, but its mechanism targeting CDK1/CCNB1 remains unclear. Methods: CDK1, CCNB1, and
Rajesh Basnet +5 more
doaj +2 more sources
Biomolecules, 2021 DNMT3A mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice.
Ying Yang, Song-Fang Wu, Yue-Ying Wang
exaly +3 more sources
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +4 more sources
Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions [PDF]
, 2022 Sam68, also known as KHDRBS1, is a member of the STAR family of proteins that directly link signal transduction with post-transcriptional gene regulation.
Idir Malki (551025) +9 more
core +5 more sources