Results 11 to 20 of about 74,242 (343)

Compartmentalized control of Cdk1 drives mitotic spindle assembly [PDF]

Cell Reports, 2022
Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle.
Angela Flavia Serpico, Francesco Febbraro, Caterina Pisauro, Domenico Grieco   +3 more
doaj   +5 more sources

Bioinformatics Analysis and Validation Identify CDK1 and MAD2L1 as Prognostic Markers of Rhabdomyosarcoma

Cancer Management and Research, 2020
Suying Lu,1,2,* Chengtao Sun,3,* Huimou Chen,1,2,* Chao Zhang,1,4,* Wei Li,5 Liuhong Wu,1,2 Jia Zhu,1,2 Feifei Sun,1,2 Junting Huang,1,2 Juan Wang,1,2 Zijun Zhen,1,2 Ruiqing Cai,1,2 Xiaofei Sun,1,2 Yizhuo Zhang,1,2 Xing Zhang1,6 1State Key Laboratory of ...
Lu S, Sun C, Chen H, Zhang C, Li W, Wu L, Zhu J, Sun F, Huang J, Wang J, Zhen Z, Cai R, Sun X, Zhang Y, Zhang X   +14 more
doaj   +1 more source

Structural basis of human separase regulation by securin and CDK1–cyclin B1

Nature, 2021
Jun Yu, Pierre Raia, David Morgan
exaly   +2 more sources

CDK1 may promote breast cancer progression through AKT activation and immune modulation [PDF]

Frontiers in Oncology
BackgroundCyclin-dependent kinase 1 (CDK1) plays a crucial role in regulating the cell cycle, yet its clinical relevance and molecular mechanisms in breast cancer remain insufficiently characterized.
Huanhong Zeng, Minxue Zhuang, Bochuan Liang, Feili Cai, Mengbo Lin, Ruijuan Wang, Ruo Wang, Hui Zhang   +7 more
doaj   +2 more sources

Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]

, 2010
The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire, Fan, Ming, Li, Jian Jian, Nantajit, Danupon, Reed, John C, Wen, Yunfei   +5 more
core   +18 more sources

COLD ATMOSPHERIC PLASMA TREATMENT MODULATES THE EXPRESSION OF cdk1, tnfα AND tp53 GENES IN HUMAN OSTEOSARCOMA CELLS

Journal of Experimental and Molecular Biology, 2023
Osteosarcoma (OS), a malignancy primarily affecting children and adolescents, is the most frequently encountered malignant, non-hematologic, bone tumor.
Alexandru Bogdan Stache, Ilarion Mihăilă, Ioana Cristina Gerber, Loredana Mihaiela Dragoș, Cosmin Teodor Mihai, Iuliu Cristian Ivanov, Ionuț Topală, Dragoș-Lucian Gorgan   +7 more
doaj   +1 more source

CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis

Journal of Translational Medicine, 2022
Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is still the only first-line treatment ...
Li-wen Ren, Yihui Yang, Wan Li, Xiang-jin Zheng, Jin-yi Liu, Sha Li, Han Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, W. Fu, Dexin Dong, Guanhua Du, Jinhua Wang   +13 more
semanticscholar   +1 more source

Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

Advancement of science, 2023
Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo ...
Tangming Guan, Mei Li, Yan Song, Jiayi Chen, Jiaxin Tang, Caishi Zhang, Yalei Wen, X. Yang, Lei Huang, Yi Zhu, Hongxian Wang, Ke Ding, Junxia Zheng, Haoxing Zhang, Tongzheng Liu   +14 more
semanticscholar   +1 more source

The effect of vitrification after warming on the expressions of p38, CDK1, and cyclin B in immature goat oocytes followed by in vitro maturation [PDF]

Veterinary World, 2020
Background and Aim: The combination of vitrification techniques and in vitro maturation can reduce oocyte competence. Mitogen-activated protein kinase and maturation-promoting factor are significant in oocyte meiotic maturation regulation.
A. A. Muhammad Nur Kasman, Budi Santoso, Widjiati Widjiati   +2 more
doaj   +1 more source

The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma

Cell Death and Disease, 2023
Super-enhancers (SEs) are regulatory element clusters related to cell identity and disease. While the studies illustrating the function of SE-associated long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD) remains few. In our research, a SE-driven
Yipeng Feng, Te Zhang, Zeyu Zhang, Yingkuan Liang, Hui Wang, Yuzhong Chen, Xinnian Yu, Xuming Song, Q. Mao, W. Xia, Bing Chen, Lin Xu, Gaochao Dong, F. Jiang   +13 more
semanticscholar   +1 more source