Results 41 to 50 of about 173,452 (162)
Identifying dynamical systems with bifurcations from noisy partial observation [PDF]
, 2012 Dynamical systems are used to model a variety of phenomena in which the bifurcation structure is a fundamental characteristic. Here we propose a statistical machine-learning approach to derive lowdimensional models that automatically integrate ...
A. P. Dempster +11 more
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Frontiers in Plant ScienceThe shoot apex of Populus alba primarily comprises the shoot apical meristem, axillary meristem, leaf primordium, and young leaves, all of which exhibit high division potential. The single-cell RNA sequencing of the apical buds of P.
Jing-hui Liang +21 more
doaj +1 more source
Cancer is a side effect of evolution of viruses and bacteria [PDF]
, 2011 Any human organism is home to viruses and bacteria. However, viruses (as well as other intracellular parasites) are interested in continuous division of the host cells.
Valentin Mitin
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Molecular and Cellular Biology, 1994 Herpesvirus saimiri contains an open reading frame called eclf2 with homology to the cellular type D cyclins. We now show that the eclf2 gene product is a novel virus-encoded cyclin (v-cyclin). The protein encoded by the v-cyclin gene of this oncogenic herpesvirus was found to have an apparent molecular size of 29 kDa in transformed cells.
J U, Jung, M, Stäger, R C, Desrosiers
openaire +2 more sources
Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
Pharmaceutical Biology, 2023 Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang +4 more
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Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]
, 1996 We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core
Turkish Journal of Hematology, 2012 OBJECTIVE: Etiopathology of malignancy can be demonstrated by the comparison of the quantified changes in the different phases of the cycle about cyclins and cyclin dependent kinase inhibitors (CDKI) in healthy and malignant proliferated cells.
Selami Koçak Toprak +4 more
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M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]
, 2019 Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao +7 more
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Frontiers in Microbiology, 2017 Dinoflagellates undergo a typical eukaryotic cell cycle consisting of G1, S, G2, and M phases and some of the typical cell cycle related genes have been computationally identified.
Xinguo Shi +3 more
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Coming of Age: Targeting Cyclin K in Cancers
Cells, 2023 Cyclins and cyclin-dependent kinases (CDKs) play versatile roles in promoting the hallmarks of cancer. Therefore, cyclins and CDKs have been widely studied and targeted in cancer treatment, with four CDK4/6 inhibitors being approved by the FDA and many ...
Yi Xiao, Jixin Dong
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