Results 61 to 70 of about 372,752 (258)
Frontiers in Plant ScienceThe shoot apex of Populus alba primarily comprises the shoot apical meristem, axillary meristem, leaf primordium, and young leaves, all of which exhibit high division potential. The single-cell RNA sequencing of the apical buds of P.
Jing-hui Liang +21 more
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, 2023 Cyclin-dependent kinases (CDKs) play a key role in activating essential cell biology processes including cellular proliferation. Inappropriate regulation of CDKs has been implicated in driving several different forms of cancer.
John, Hayward +4 more
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Lappaol F regulates the cell cycle by activating CDKN1C/p57 in human colorectal cancer cells
Pharmaceutical Biology, 2023 Context Lappaol F (LAF), a natural lignan from Arctium lappa Linné (Asteraceae), inhibits tumor cell growth in vitro and in vivo. The underlying mechanism involves the suppression of the Yes-associated protein.
Rui-Yi Yang +4 more
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Genes & Development, 1994 Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink epithelial cells arrested by either mechanism are incapable of assembling active complexes containing the G1 cyclin, cyclin E, and its catalytic subunit, Cdk2.
K. Polyak +6 more
semanticscholar +1 more source
The amyloid-β peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity
, 2002 The pathological features of Alzheimer's disease include deposition of amyloid-β (Aβ) containing plaques and increases in the expression of cyclin-dependent kinase (CDK) enzymes.
Milton, N.G.N.
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Turkish Journal of Hematology, 2012 OBJECTIVE: Etiopathology of malignancy can be demonstrated by the comparison of the quantified changes in the different phases of the cycle about cyclins and cyclin dependent kinase inhibitors (CDKI) in healthy and malignant proliferated cells.
Selami Koçak Toprak +4 more
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Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein’s C-Terminal Helix
bioRxiv, 2018 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein, Rb, which inhibits cell cycle progression until its inactivation by ...
Benjamin R. Topacio +8 more
semanticscholar +1 more source
Frontiers in Microbiology, 2017 Dinoflagellates undergo a typical eukaryotic cell cycle consisting of G1, S, G2, and M phases and some of the typical cell cycle related genes have been computationally identified.
Xinguo Shi +3 more
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Coming of Age: Targeting Cyclin K in Cancers
Cells, 2023 Cyclins and cyclin-dependent kinases (CDKs) play versatile roles in promoting the hallmarks of cancer. Therefore, cyclins and CDKs have been widely studied and targeted in cancer treatment, with four CDK4/6 inhibitors being approved by the FDA and many ...
Yi Xiao, Jixin Dong
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The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival
Nature, 2017 D-type cyclins (D1, D2 and D3) and their associated cyclin-dependent kinases (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell proliferation.
Haizhen Wang +20 more
semanticscholar +1 more source