Results 81 to 90 of about 372,752 (258)
The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]
, 2011 Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha +2 more
core
, 2012 P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported.
Perearnau Garcia, Anna +12 more
core +1 more source
Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]
, 2003 Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A. +11 more
core +1 more source
Cyclin K and cyclin D1b are oncogenic in myeloma cells [PDF]
Molecular Cancer, 2010 AbstractBackgroundAberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL).CCND1gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b.
Marsaud, Véronique +8 more
openaire +3 more sources
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
Genes & Development, 1993 A cascade of events is triggered upon the addition of growth factor to quiescent mammalian cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase. We have studied cyclin D1, a putative G1 cyclin, in normal diploid
ronique Baldin +4 more
semanticscholar +1 more source
, 2021 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. HCC cells possess biological characteristics of high invasion and metastasis.
Lin-Han Lei (11717427) +5 more
core +1 more source
Cyclins and the cyclin-kinase system, and their potential roles in nephrology [PDF]
Nephrology Dialysis Transplantation, 1998 Our understanding of the cell-cycle mechanisms has progressively advanced in the past few years. Cyclins and cyclin-dependent kinases play major roles as positive cell-cycle regulatory proteins and CDK inhibitors; while the Kip family and INK4 family are negative regulatory proteins in mesangial cells and renal tubular cells.
Y, Terada +5 more
openaire +2 more sources
Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast
Autophagy Reports, 2022 Cyclins are degraded by the anaphase-promoting complex/cyclosome (APC/C)-mediated proteasome in normal mitosis. We showed that Cdc13 (cyclin B) is also degraded by macroautophagy/autophagy in sulfur-deficient fission yeast.
Hokuto Ohtsuka +10 more
doaj +1 more source
Asynchronous nuclear division cycles in multinucleated cells [PDF]
, 2006 Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Peter Philippsen +5 more
core +1 more source
Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
Molecular Systems Biology, 2009 Cyclin‐dependent kinase (Cdk) both promotes mitotic entry (spindle assembly and anaphase) and inhibits mitotic exit (spindle disassembly and cytokinesis), leading to an elegant quantitative hypothesis that a single cyclin oscillation can function as a ...
Benjamin J Drapkin +4 more
doaj +1 more source