Results 31 to 40 of about 372,752 (258)

Cyclin C: The Story of a Non-Cycling Cyclin [PDF]

Biology, 2019
The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek, Daniel G. J. Smethurst, David C. Stieg, Z. A. C. Kiss, Sara E. Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F. Cooper, Randy Strich   +8 more
openaire   +4 more sources

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H., Mullers, E, Cascales, H.S., Cascales, HS, Lindqvist, A., Jaiswal, H, Saurin, AT, Lindqvist, A,, Müllers, E., Saurin, A.T.; id_orcid   +9 more
core   +1 more source

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature reviews. Drug discovery, 2015
Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies.
U. Asghar, A. Witkiewicz, N. Turner, E. Knudsen   +3 more
semanticscholar   +1 more source

The double dealing of cyclin D1 [PDF]

Cell Cycle, 2019
The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
Guergana Tchakarska, B. Sola
semanticscholar   +1 more source

LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Nature Communications, 2020
Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer.
Qianfeng Shi, Yudong Li, Shunying Li, Liang Jin, Hongna Lai, Yanqin Wu, Zijie Cai, Mengdi Zhu, Qian Li, Ying Li, Jingru Wang, Yujie Liu, Zongyang Wu, E. Song, Qiang Liu   +14 more
semanticscholar   +1 more source

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
core   +1 more source

Isolation and characterization of cold inducible genes in carrot by suppression subtractive hybridization

Biologia Plantarum, 2013
Daucus carota is cultivated widely but grows best in cool climates. Suppression subtractive hybridization (SSH) is a PCR based method used to selectively amplify differentially expressed cDNAs and simultaneously suppress non-target cDNA.
S. R. Kumar, S. Anandhan, S. Dhivya, A. Zakwan, R. Sathishkumar   +4 more
doaj   +1 more source

Modification of Transfer RNA Levels Affects Cyclin Aggregation and the Correct Duplication of Yeast Cells

Frontiers in Microbiology, 2021
Codon usage bias (the preferential use of certain synonymous codons (optimal) over others is found at the organism level (intergenomic) within specific genomes (intragenomic) and even in certain genes.
Loreto Arias, Fabián Martínez, Daniela González, Rodrigo Flores-Ríos, Assaf Katz, Mario Tello, Sandra Moreira, Omar Orellana   +7 more
doaj   +1 more source

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
Sarkar, S. (Sourav), Sourav Sarkar, Novák, Béla, Tibbles, Katherine L., Prakash Arumugam, Arumugam P., Bela Novak (5648875), Sarkar S., Arumugam Prakash, Arumugam, Prakash, Sourav Sarkar (430861), Katherine Louise Tibbles (478963), Katherine Louise Tibbles, Bela Novak, Sarkar Sourav, Novak Bela, Tibbles Katherine Louise, Prakash Arumugam (303310), Tibbles K.L., Novak B.   +19 more
core   +1 more source

The Hunt for Cyclin [PDF]

Cell, 2008
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
openaire   +3 more sources