Results 81 to 90 of about 50,848 (283)

Transcriptional cyclin-dependent kinases as therapeutic targets in bone metastasizing cancers

Frontiers in Oncology
Cyclin-dependent kinases (CDKs) are established and emerging drug targets in cancer. Clinical success of CDK4/6 inhibitors in HR+/HER2- breast cancer has validated the CDK family therapeutically and stimulated development of both next-generation cell ...
Tiina E. Kähkönen, Gergana Galabova, Michael Thormann, Jussi M. Halleen   +3 more
doaj   +1 more source

CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation. [PDF]

PLoS ONE, 2011
Cyclin-dependent kinases (CDKs) and their targets have been primarily associated with regulation of cell-cycle progression. Here we identify c-Jun, a transcription factor involved in the regulation of a broad spectrum of cellular functions, as a newly ...
Tony J Vanden Bush, Gail A Bishop
doaj   +1 more source

Characterization and functional analysis of chicken CDK protein

Poultry Science
: The family of cell cycle-dependent kinases (CDKs) serves as catalytic subunits within protein kinase complexes, playing a crucial role in cell cycle progression.
Zhixuan Xiong, Jingjing Cao, Ke Wang, Yuling Yang, Ying Hu, Jiangjiang Nie, Qinghua Zeng, Yu Hu, Lina Zhu, Xiangzhi Li, Huansheng Wu   +10 more
doaj   +1 more source

Targeting CDK1 in cancer: mechanisms and implications

npj Precision Oncology, 2023
Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression.
Qiushi Wang, Ann M. Bode, Tianshun Zhang
doaj   +1 more source

The working model for the timing control of spindle elongation by the balance of mitotic versus S-phase CDKs.

, 2013
The working model for the timing control of spindle elongation by the balance of mitotic versus S-phase CDKs.
Fengshan Liang (269153), Yanchang Wang (185514), Daniel Richmond (383461)   +2 more
core   +1 more source

Cyclin-dependent kinases and rare developmental disorders

Orphanet Journal of Rare Diseases, 2020
Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during development.
Pierre Colas
doaj   +1 more source

Cdk2 is required for p53-independent G2/M checkpoint control. [PDF]

PLoS Genetics, 2010
The activation of phase-specific cyclin-dependent kinases (Cdks) is associated with ordered cell cycle transitions. Among the mammalian Cdks, only Cdk1 is essential for somatic cell proliferation.
Jon H Chung, Fred Bunz
doaj   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Sequence similarity of full-length CDKs (global AA similarity) and the amino acid residues constituting the local structure on CDK9 surrounding 127 (local AA similarity).

, 2022
Sequence similarity of full-length CDKs (global AA similarity) and the amino acid residues constituting the local structure on CDK9 surrounding 127 (local AA similarity).
Takashi Okamoto (433928), Kaori Asamitsu (433926), Takatsugu Hirokawa (59421)   +2 more
core   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source