Results 91 to 100 of about 50,848 (283)
Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Signal Transduction and Targeted TherapyCyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division.
Ilenia Pellarin +8 more
doaj +1 more source
Expert opinion on therapeutic targets, 2010 Importance of the field: The eukaryotic cell division cycle is a tightly regulated series of events coordinated by the periodic activation of multiple cyclin-dependent kinases (cdks).
N. Johnson, G. Shapiro
semanticscholar +1 more source
, 1999 International audienceWe have overexpressed and purified human dual-specificity phosphatase cdc25C from a prokaryotic expression system at high levels and in a soluble, active form, and have studied and quantified its potential to interact with cdks ...
Divita, Gilles, Morris, May
core +1 more source
Transcriptional CDKs in the spotlight [PDF]
Transcription, 2019 At every active gene in any genome, there is a transcription cycle, defined as the collective set of biochemical reactions that control RNA polymerase activity, from promoter binding to polymerase ...
openaire +2 more sources
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
The inhibitors of cyclin-dependent kinases and GSK-3β enhance osteoclastogenesis
Biochemistry and Biophysics Reports, 2016 Osteoclasts are multinucleated cells with bone resorption activity that is crucial for bone remodeling. RANK‐RANKL (receptor activator of nuclear factor κB ligand) signaling has been shown as a main signal pathway for osteoclast differentiation. However,
Yosuke Akiba +7 more
doaj +1 more source
Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. [PDF]
PLoS ONE, 2009 Cyclin-dependent kinases (CDKs) play important roles in regulating cell cycle progression, and altered cell cycles resulting from over-expression or abnormal activation of CDKs observed in many human cancers.
Jing Xiang +9 more
doaj +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Organoid Coculture Models for Cancer Research and Immunotherapy
Med Research, EarlyView.This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang +9 more
wiley +1 more source
Cell Cycle, 2010 It is long known that stem cell differentiation correlates with a lengthening of the cell cycle, in particular G1. Moreover, models were proposed for mammalian embryonic, neural and hematopoietic stem cells whereby lengthening of G1 is a cause, rather ...
Christian Lange, F. Calegari
semanticscholar +1 more source