Results 111 to 120 of about 50,848 (283)

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Precision Radiation Oncology, EarlyView.
This study underscores the critical role of PTMs in mediating cellular responses to X‐ray and Carbon ion irradiation radiotherapy in HNSCC. The integration of multi‐omics data provides insights into the molecular mechanisms underlying radiation‐induced changes, offering valuable clues for improving therapeutic outcomes and advancing precision medicine ...
Fan‐Tong Xia, Zhi‐Yun Liao, Si‐Qi Cai, Li‐Rong Zhou, Meng‐Qi Yang, Xin Zhang, Dan Li, Huan Zhang, Yun‐Chang Liu, Jie‐Ying Yang, Jia Jiang, Yi‐Hong Hu, Jiang‐Dong Sui, Ying Wang   +13 more
wiley   +1 more source

STRUCTURAL BIOINFORMATICS STUDY OF CYCLIN-DEPENDENT KINASES COMPLEXED WITH INHIBITORS

Eclética Química, 2018
The present work describes molecular models for the binary complexes CDK9, CDK5 and CDK1 complexed with Flavopiridol and Roscovitine. These structural models indicate that the inhibitors strongly bind to the ATP-binding pocket of CDKs and the structural ...
F. CANDURI, N. J. F. da SILVEIRA, J. C. CAMERA JR, W. F. W. F. dd   +3 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

FEWT: Frequency‐Enhanced Wavelet‐Based Transformer for Multimodal Wheeled Bimanual Manipulation

SmartBot, EarlyView.
An embodied mobile bimanual robot learns dexterous manipulation skills through imitation learning with multimodal perception. The integration of vision, proprioception, and tactile sensing establishes a comprehensive perception–action loop, enabling the robot to continuously understand, interact with, and adapt to complex physical environments.
Jiaxin Huang, Hanyu Liu, Yunsheng Ma, Jian Shen, Yilin Zheng, Jiayi Wen, Zhigong Song   +6 more
wiley   +1 more source

Castration-resistant prostate cancer cells are addicted to the high activity of cyclin-dependent kinase 2. [PDF]

Mol Oncol
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Chatterjee J, Marin A, Yalala S, Itkonen HM.   +3 more
europepmc   +2 more sources

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

QM and QM/MM studies of the phosphoryl transfer reaction catalyzed by a cyclin-dependent kinase (CDKS)

, 2004
The study focused on the use of QM/MM simulations to investigate enzymatic reaction in targets of pharmaceutical relevance. The regulation of the eukaryotic cell cycle depends on the action of several related Ser/Thr protein kinases called cyclin ...
RECANATINI, MAURIZIO, De Vivo M., CAVALLI, ANDREA, Carloni P., Roethlisberger U.   +4 more
core   +1 more source

Roscovitine derivative optimization via molecular dynamics reveals potent and selective CDK5 binders

Frontiers in Chemical Biology
CDK5 is an atypical member of the CDKs family that is not directly involved in cell cycle regulation but has a very relevant role in promoting DNA damage response and immune response evasion in cancer.
Lorenzo Botta, Giovanni Carotenuto, Manuel Arcieri, Elena Di Nisio, Valerio Perticaroli, Tiziana Castrignanò, Raffaele Saladino, Rodolfo Negri   +7 more
doaj   +1 more source