Results 111 to 120 of about 27,135 (258)

Targeting the cyclin-dependent kinase family in anticancer drug discovery: From computational to experimental studies

Chemical Physics Impact
Uncontrolled cell proliferation, primarily regulated by cyclin-dependent kinases (CDKs), is a critical driver of cancer progression, with dysregulation of CDKs contributing to various cancer types. CDKs have emerged as well-established targets for cancer
Priyanka Solanki, Shubhangi Sarwadia, Mohd Athar, Prakash C. Jha, Anu Manhas   +4 more
doaj   +1 more source

Wee1 kinase differentially regulates maize CDKA2;1a and CDKB1;1

The FEBS Journal, EarlyView.
In eukaryotes, Wee1 kinase inhibits the kinase activity of CDK/Cyc complexes through phosphorylation of a conserved residue in the CDK moiety. Wee1 is also present in plants, but has been scarcely studied. We have studied maize Wee1 regulation of CDKA/CycD2;2a or CDKB/CycD2;2a complexes.
Mingyar N. López‐Hernández, Estefany D. Guerrero‐Molina, Ulises Martínez‐Ortega, Aurora Lara‐Núñez, Jorge M. Vázquez‐Ramos   +4 more
wiley   +1 more source

Evolution of Eukaryotic Cell Cycle Regulation Stepwise Addition of Regulatory Kinases and Late Advent of the CDKs

, 2003
Protein kinases regulate a number of critical events in mitosis and meiosis. A study of the evolution of kinases involved in cell cycle control (CCC) might shed light on the evolution of the eukaryotic cell cycle.
Koonin, Eugene V., Krylov, Dmitri M., Nasmyth, Kim   +2 more
core   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

The working model for the timing control of spindle elongation by the balance of mitotic versus S-phase CDKs.

, 2013
The working model for the timing control of spindle elongation by the balance of mitotic versus S-phase CDKs.
Fengshan Liang (269153), Yanchang Wang (185514), Daniel Richmond (383461)   +2 more
core   +1 more source

Small Bowel Lesions and Bleeding Risk in Hemodialysis Patients: A Narrative Review

Hemodialysis International, EarlyView.
ABSTRACT Background Gastrointestinal bleeding is very common among hemodialysis patients. This high bleeding risk is caused by uremic platelet dysfunction, vascular fragility, intradialytic hemodynamic instability, and widespread antithrombotic therapy.
Andreas Smyrlis, Konstantia Kantartzi, Konstantinos Mimidis, Stylianos Panagoutsos   +3 more
wiley   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

Centromeres Poised En Pointe: CDKs Put a Hold on CENP-A Assembly

, 2012
Eukaryotic centromeres are propagated by incorporation of the centromere-specific histone CENP-A into centromeric chromatin. Silva et al. (2012) now show that cyclin-dependent kinases (CDKs) hold the CENP-A assembly machinery in an inactive state until ...
Sullivan, Beth A., Stimpson, Kaitlin M.   +1 more
core   +1 more source

Alleviation of photoaging‐associated MMP upregulation, prostanoid biosynthesis, and cell cycle arrest with titanium dioxide, zinc oxide, and inorganic‐only (ZnO + TiO2) sunscreens

Photochemistry and Photobiology, EarlyView.
Inorganic sunscreens containing the UV filters titanium dioxide (TiO2) and/or zinc oxide (ZnO) alleviated various biomarkers of photoaging in human dermal fibroblasts, at a gene and protein level. The study provides novel insights that observe the impact of inorganic photoprotection through the molecular biology of skin.
Neil Dominic T. Pangilinan, Mohammad Shalbaf, Aline Souza, Bhaven Chavan, Mark A. Birch‐Machin   +4 more
wiley   +1 more source