Results 121 to 130 of about 27,135 (258)

Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs

, 2011
Background: Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells including control over the cell cycle and gene transcription.
Stiller, John W., NC DOCKS at East Carolina University, Guo, Zhenhua   +2 more
core  

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Cyclin-Dependent Kinase for Cancer Therapy

Molecules
The regulation of the cancer cell cycle heavily relies on cyclin-dependent kinases (CDKs). Targeting CDKs has been identified as a promising approach for effective cancer therapy.
Ya-Tao Wang, Shi-Qi Jiang, Shao-Lin Zhang   +2 more
doaj   +1 more source

Real‐world progression‐free survival and overall survival in patients with HR+/HER2− advanced breast cancer treated in first‐line with ribociclib, endocrine monotherapy or chemotherapy: Results from the observational RIBANNA study

International Journal of Cancer, Volume 159, Issue 1, Page 210-223, 1 July 2026.
What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Peter A. Fasching, Cosima Brucker, Thomas Decker, Anne Engel, Thomas Göhler, Christian Jackisch, Jan Janssen, Andreas Köhler, Kerstin Lüdtke‐Heckenkamp, Diana Lüftner, Frederik Marmé, Marion van Mackelenbergh, Beate Rautenberg, Marcus Schmidt, Rudolf Weide, Pauline Wimberger, Elena Kisseleff, Christina Pfister, Claudia Quiering, Christian Roos, Achim Wöckel   +20 more
wiley   +1 more source

Age, Age‐Related Comorbidities and Survival in Palbociclib, Ribociclib and Abemaciclib Users With Advanced Breast Cancer: A Nation‐Wide Retrospective Cohort Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 7, July 2026.
ABSTRACT Purpose Prevalence of breast cancer (BC) increases with age, but the external validity of data obtained from pivotal trials of medicinal products remains a concern due to the underrepresentation of frail and older adults. Cyclin‐dependent kinase inhibitors (CDKi), palbociclib, abemaciclib, and ribociclib are considered an essential part of the
Blair Rajamaki, Olli Tenhunen, Liisa Pylkkänen, Thuan Vo, Anne Paakinaho, Miia Turpeinen, Sirpa Hartikainen, Anna‐Maija Tolppanen   +7 more
wiley   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

TARGETING CDKs TO INHIBIT THE HIV-1 TAT-MEDIATED TRANSCRIPTION

, 2013
The activity of the CDKs is critical for HIV-1 Tat-mediated transcription and represents a promising target for antiviral therapy.(1) Taking advantage of the crystallographic data of CDK9 in complex with flavopiridol,(2) we have recently performed ...
SANCINETO, LUCA, MANFRONI, GIUSEPPE, IRACI, NUNZIO, BARRECA, MARIA LETIZIA, SABATINI, STEFANO, TABARRINI, Oriana, MASSARI, SERENA, CECCHETTI, Violetta   +7 more
core  

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E, Ainscough, Justin F X, Coverley, Dawn, Copeland, Nikki A   +3 more
core  

Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design.

, 2013
Cyclin-dependent kinases (CDKs) belong to the CMGC subfamily of protein kinases and play crucial roles in eukaryotic cell division cycle. At least seven different CDKs have been reported to be implicated in the cell cycle regulation in vertebrates. These
Soumya Lipsa Rath (458566), Soumya Lipsa Rath, Sanjib Senapati, Sanjib Senapati (148857)   +3 more
core   +1 more source