Results 141 to 150 of about 50,848 (283)

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Cyclin-Dependent Kinase for Cancer Therapy

Molecules
The regulation of the cancer cell cycle heavily relies on cyclin-dependent kinases (CDKs). Targeting CDKs has been identified as a promising approach for effective cancer therapy.
Ya-Tao Wang, Shi-Qi Jiang, Shao-Lin Zhang   +2 more
doaj   +1 more source

Molecular basis of differential selectivity of cyclobutyl-substituted imidazole inhibitors against CDKs: insights for rational drug design.

, 2013
Cyclin-dependent kinases (CDKs) belong to the CMGC subfamily of protein kinases and play crucial roles in eukaryotic cell division cycle. At least seven different CDKs have been reported to be implicated in the cell cycle regulation in vertebrates. These
Soumya Lipsa Rath (458566), Soumya Lipsa Rath, Sanjib Senapati, Sanjib Senapati (148857), Rath Soumya Lipsa, Senapati Sanjib   +5 more
core   +1 more source

Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development

The FEBS Journal, EarlyView.
Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék, Aladár Pettkó‐Szandtner, Anikó Szabó, Balázs Vedelek, Bence György Gombás, Zoltán Villányi, Péter Vilmos, Imre Miklós Boros, László Henn, Gyula Timinszky   +9 more
wiley   +1 more source

Estudio de la muerte inducida por el inhibidor de CDKs Dinaciclib en células de mieloma múltiple [PDF]

, 2016
El mieloma múltiple es una enfermedad caracterizada por la proliferación incontrolada de células B monoclonales que se acumulan en la médula ósea donde proliferan de forma lenta pero con una alta supervivencia.
Naval, Javier, De Miguel Samaniego, Diego, de Benito Bueno, Ángela   +2 more
core  

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

UK recommendations for Ki‐67 immunohistochemical staining and interpretation in breast cancer

Histopathology, EarlyView.
Where possible, a validated digital imaging system should be utilized. If this is not available, then intermediate scores (5%–30%) should be thoroughly assessed using the Ki‐67 International Working Group guidance. Difficult cases should be double scored.
Abeer M Shaaban, Andrew Dodson, Emad Rakha, Ian Ellis, Daniel Rea, Cecily Quinn, Elena Provenzano, Sarah Pinder, on behalf of the UK National Coordinating Committee for Breast Pathology (NCCBP), Association of Breast Pathology (ABP) and the UK National External Quality Assessment Scheme for Immunohistochemistry and In Situ Hybridisation (UK NEQAS ICC & ISH)   +9 more
wiley   +1 more source

Excess endopolyploidy associated with cellular defects in neo‐autotetraploid Arabidopsis arenosa is in part corrected by a naturally evolved allele of CYCD3;2

New Phytologist, EarlyView.
Ploidy level distributions and endoreduplication profiles in diploid and tetraploid Arabidopsis arenosa. Summary Endopolyploidy (within‐organism polyploidy) is an often‐beneficial aspect of development. But polyploids, which have a higher baseline genome content, have been reported to have less endoreduplication than diploid relatives. Why has remained
Anis Meschichi, Marinela Dukić, Lars C. Schmid, Andreas L. Bachmann, Tadeas J. Priklopil, Hui San Tan, Kirsten Bomblies   +6 more
wiley   +1 more source

Localization dynamics of cyclin-dependent kinases (CDKs) in the rice blast fungus Magnaporthe oryzae

El hongo filamentoso Magnaporthe oryzae causa la enfermedad de la quemazón del arroz. Afecta a más de 50 especies, incluyendo cultivos esenciales como el arroz, la cebada, el mijo y el trigo, y destruye hasta el 30% de la producción anual de arroz.
Fagoaga Izquierdo, Ane
core  

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source