Results 141 to 150 of about 27,135 (258)
Version 2.12 of the Chemistry Development Kit has been released. It is the last release with contributions by our NWO Open Science grant.
openaire +2 more sources
Targeting Transcriptional CDKs in Medulloblastoma
Medulloblastoma (MB) is the most common malignant tumour of the brain in children. Current treatments include surgery, radiotherapy and chemotherapy. Although the five-year survival rate is over 70%, the treatment is exceptionally aggressive, leaving ...
Safari, Nazila
core
Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu +5 more
wiley +1 more source
, 2009 PubChem-CDK is a project that runs CDK code on the PubChem data. As we speak, a groovy script reads about 100 PubChem Compounds XML entries per second into the database. Mind you, not the SDF they distribute which uses a custom extension to overcome the limits of the real MDL SDF format.
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Localization dynamics of cyclin-dependent kinases (CDKs) in the rice blast fungus Magnaporthe oryzae
El hongo filamentoso Magnaporthe oryzae causa la enfermedad de la quemazón del arroz. Afecta a más de 50 especies, incluyendo cultivos esenciales como el arroz, la cebada, el mijo y el trigo, y destruye hasta el 30% de la producción anual de arroz.
Fagoaga Izquierdo, Ane
core
, 2013 Krebs ist eine Erkrankung mit wachsenden Inzidenzzahlen, daher es ist wichtig kontinuierliche Fortschritte in dessen Therapie zu erreichen. Eine der größten Herausforderungen ist die Heterogenität der Erkrankung, welche sogar innerhalb einen Patienten ...
Komina, Oxana
core
Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri +10 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Overview of extraction, biological activities, and application prospects of DCP. (a) Collection, weighing, shearing, and grinding of D. chrysotoxum stems. (b) Aqueous extraction, ultracentrifugation, drying, and filtration to obtain purified DCP. (c) Mechanistic studies and preclinical or retrospective clinical investigations of DCP bioactivities.
Xingshuai Zhang +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali +9 more
wiley +1 more source
, 2005 One of the Classpath developers pointed me to their CVS statistics when I asked them how actively their project is currently developed, i.e. the number of active developers.
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