Results 161 to 170 of about 27,135 (258)

Aberrant polyploidization pathways in megakaryocytes as therapeutic targets in leukemia. [PDF]

Ann Med Surg (Lond)
Obeagu EI.
europepmc   +1 more source

Integrative Proteogenomic Characterization of Left‐Sided and Right‐Sided Colorectal Cancer

MedComm, Volume 7, Issue 6, June 2026.
This study performed whole‐exome sequencing, proteomic, and phosphoproteomic analysis on 80 pairs of tumor tissues and matched normal adjacent tissues from colorectal cancer patients. The integrated proteogenomic study provides a comprehensive and nuanced understanding of the molecular heterogeneity between left‐ and right‐sided colorectal cancer ...
An Huang, Haopeng Hong, Yonghui Sun, Zhaoya Gao, Jingxuan Xu, Jiajia Chen, Yong Yang, Zhongyi Chen, Hebing Chen, Ming Li, Xiaodong Wang, Jin Gu   +11 more
wiley   +1 more source

RNA polymerase II: the elephant in the room. [PDF]

Trends Genet
Henikoff S, Hahn S.
europepmc   +1 more source

QM and QM/MM studies of the phosphoryl transfer reaction catalyzed by a cyclin-dependent kinase (CDKs)

The regulation of the eukaryotic cell cycle depends on the action of several related Ser/Thr protein kinases called cyclin-dependent kinases (CDKs), which are transiently activated at specific stages of the cycle, and which are also very promising ...
Roethlisberger, Ursula, De Vivo, Marco, Recanatini, Maurizio, Cavalli, Andrea, Carloni, Paolo   +4 more
core  

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy. [PDF]

Cancer Res
Rubin SM, Sage J, Skotheim JM.
europepmc   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

PROTACs for Collateral Degradation: Is It Time to Back Up the Bus? [PDF]

ACS Med Chem Lett
Gao ZG, Burgess K.
europepmc   +1 more source

Identification of CDKs as Novel Targets of Aspirin and Its Metabolites: A Potential Role in Cancer Prevention

, 2017
Background:The pursuit of drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. Till date, although multiple CDK inhibitors have been identified and few are undergoing clinical trials, only two ...
Dachineni, Rakesh
core  

Evolution of Thiosemicarbazones: From First‐ to Second‐Generation Metal Chelators and Their Reactive Oxygen Species‐Mediated Effects in Melanoma

ChemistryOpen, Volume 15, Issue 6, June 2026.
Thiosemicarbazones (TSC) have demonstrated promise as new chemotherapeutic agents against melanoma in both in vitro and In vivo studies. TSC are powerful metal coordinating agents, coordinating transition metal ions such as zinc, copper and iron in multiple oxidation states. It is this metal coordination that imparts the anticancer activity.
Rohina Alim, Scott D. Andrew, Christopher J. Parkinson   +2 more
wiley   +1 more source