Results 181 to 190 of about 50,848 (283)

Impact of selective inhibition of CDKs on the integration of nuclear events in cancer cells with varying proliferation potential

, 2013
Krebs ist eine Erkrankung mit wachsenden Inzidenzzahlen, daher es ist wichtig kontinuierliche Fortschritte in dessen Therapie zu erreichen. Eine der größten Herausforderungen ist die Heterogenität der Erkrankung, welche sogar innerhalb einen Patienten ...
Komina, Oxana
core  

The SlHYL1‐SlRBP1 module integrates gibberellin metabolism to promote plant height in tomato (Solanum lycopersicum)

The Plant Journal, Volume 128, Issue 3, November 2026.
SUMMARY Plant height is an essential agronomic trait that significantly influences crop yield and quality. The HYPONASTIC LEAVES 1 (HYL1), a core component of microRNA biogenesis, remains poorly understood in terms of its regulatory mechanisms on agronomic traits in tomato (Solanum lycopersicum, Sl).
Xingxing Zhang, Miao Chai, Linjing Cao, Shengbo Chen, Kun Zhao, Jiazhen Han, Ning Li, Hongjiao Zhao, Shengjun Feng, Bo Wang, Shengze Zhang, Yumeng Li, Mingze Xu, Guodong Ren, Shuai Gao   +14 more
wiley   +1 more source

CMGC Kinases in Viral Infection and Human Disease. [PDF]

Pathogens
Amusan OT, Guo H.
europepmc   +1 more source

Mammalian interphase cdks: dispensable master regulators of the cell cycle.

Genes & cancer, 2012
G. Enders
semanticscholar   +1 more source

Nucleolin Alterations and ROS Production Associate With Sensitivity of AML Cells to Venetoclax

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Venetoclax‐induced Bcl‐2 inhibition corresponds with Mcl‐1 attenuation and decrease of Nucleolin (NCL) level and activity in sensitive cells. Simultaneously, distinct cell subpopulations with opposite mitochondrial (CellROX label, magenta) and cellular (H2DCFDA stain, green) ROS occur, and the H2DCFDA‐positive population shows markers of early ...
Kateřina Wolfová, Petra Otevřelová, Barbora Brodská   +2 more
wiley   +1 more source

A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999-2025). [PDF]

Front Bioeng Biotechnol
Derzhavina VM, Khalymbadzha IA, Yuzhalin AE.   +2 more
europepmc   +1 more source

Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants

Proceedings of the National Academy of Sciences of the United States of America, 2011
M. Sasabe, V. Boudolf, L. De Veylder, D. Inzé, P. Genschik, Y. Machida   +5 more
semanticscholar   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Inhibition of RNA polymerase II-activating CDK9 and CDK12/13, but not of cell cycle relevant CDKs, induces apoptosis by downregulating the short-lived Bcl-2 proteins Mcl1 and Bfl1/A1. [PDF]

Cell Death Dis
Krings KS, Hatzfeld J, Weller S, Borkowski N, Llewellyn TR, Schmitt L, Scherer B, Itkonen HM, Peter C, Stork B, Geyh S, Eickhoff J, Klebl B, Qin N, Essmann F, Wesselborg S.   +15 more
europepmc   +1 more source

CDK9 and hematologic malignancies: pioneering novel therapeutic approaches. [PDF]

Clin Exp Med
Raufi H, Zahmatkesh P, Safaei S, Bahadori A, Solali S.   +4 more
europepmc   +1 more source