Results 171 to 180 of about 50,848 (283)

PubChem-CDK

, 2009
PubChem-CDK is a project that runs CDK code on the PubChem data. As we speak, a groovy script reads about 100 PubChem Compounds XML entries per second into the database. Mind you, not the SDF they distribute which uses a custom extension to overcome the limits of the real MDL SDF format. Right now, it has run the atom type perception algorithm on about
openaire   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

CDK 2.12

Version 2.12 of the Chemistry Development Kit has been released. It is the last release with contributions by our NWO Open Science grant.
openaire   +2 more sources

Emodin-induced cell cycle arrest: A promising approach for cancer therapy (Review). [PDF]

Med Int (Lond)
Das S, Kompala J, Laney K, Pathak S, Nayar R, Khurana S, Ghezzi A, Karthik L, Banerjee AG.   +8 more
europepmc   +1 more source

Optimisation et caractérisation de nouveaux inhibiteurs pharmacologiques de kinases cycline-dépendantes (CDKs)

, 2008
Les kinases cycline-dépendantes (CDKs) sont des régulateurs essentiels du cycle de division cellulaire (CDK1, 2, 3, 4, 6, 7), de l apoptose (CDK1, 5), et de la transcription (CDK7, 9).
MEIJER, Laurent, BETTAYEB, Karima
core  

Atherosclerosis: Molecular Pathogenesis and Therapeutic Interventions. [PDF]

MedComm (2020)
Kaszubski J, Wawrzyniak A, Gagat M, Żuryń A.   +3 more
europepmc   +1 more source

Targetting Cdks in Cancer: An Overview and New Insights

, 2014
G. Chashoo, A. Saxena
semanticscholar   +1 more source

Targeting Transcriptional CDKs in Medulloblastoma

Medulloblastoma (MB) is the most common malignant tumour of the brain in children. Current treatments include surgery, radiotherapy and chemotherapy. Although the five-year survival rate is over 70%, the treatment is exceptionally aggressive, leaving ...
Safari, Nazila
core  

An Intronic Structural Variant in GhEBS1 Drives Cotton Fruit Size Divergence by Modulating Chromatin Accessibility and Gene Expression

Plant Biotechnology Journal, Volume 24, Issue 11, Page 6028-6044, November 2026.
ABSTRACT Fruit size is not only a crucial fitness trait in plant evolution but also an important agronomic target in crop domestication and improvement, yet its regulatory mechanisms remain poorly characterized. Here, we identified an F‐box E3 ubiquitin ligase gene, GhEBS1 (ENLARGED BOLL SIZE 1), as a positive regulator of cotton boll size via map ...
Furong Wang, Yu Chen, Zhangqiang Song, Ao Pan, Xuehan Huo, Jingxia Zhang, Yang Gao, Zhecheng Yuan, Mengchen Zhu, Mingyang Lei, Pei Zhang, Juan Zhou, Zhaohai Du, Shengli Wang, Jiaojiao Feng, Minghui Feng, Chuanban Li, Shoupu He, Tianzhen Zhang, Jun Zhang   +19 more
wiley   +1 more source

The non-canonical CDK2 activator SPY1 uses separable mechanisms to activate phosphorylated and unphosphorylated CDK2. [PDF]

Biochem J
Fawcett LP, Levinson NM.
europepmc   +1 more source