Results 11 to 20 of about 37,065 (297)
Viral Cyclins Mediate Separate Phases of Infection by Integrating Functions of Distinct Mammalian Cyclins [PDF]
PLoS Pathogens, 2012 Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee +2 more
exaly +3 more sources
The Less Known Cyclins—Uncovered
Applied Sciences (Switzerland), 2021 Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Zuryn +2 more
exaly +4 more sources
PLoS Genetics, 2013 Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulánková +2 more
exaly +4 more sources
Plasticity of mitotic cyclins in promoting the G2–M transition [PDF]
Journal of Cell BiologyCyclins and cyclin-dependent kinases (CDKs) orchestrate key events in the cell cycle. However, the uniqueness of individual mitotic cyclins has been a long-standing puzzle. By rapidly removing cyclins in G2 human cells, we found that deficiency of B-type
Adrijana Črnčec +2 more
exaly +3 more sources
Sumoylation of cyclin and its therapeutic potential for cancer [PDF]
Animal Cells and SystemsThe precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
doaj +2 more sources
Cell cyclins: triggering elements of cancer or not?
World Journal of Surgical Oncology, 2010 Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the
Pateras Ioannis +6 more
doaj +3 more sources
Cyclins and CDKs in the regulation of meiosis-specific events
Frontiers in Cell and Developmental Biology, 2022 How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events.
Inés Palacios-Blanco +1 more
doaj +2 more sources
Cyclins and Cyclin Dependent Kinases during Cardiac Development
Molecules and Cells, 1997 The molecular mechanisms that regulate the cardiomyocyte cell cycle and its terminal differentiation remain largely unknown. To determine which cyclins or cyclin dependent kinases (CDKs) are important for cardiomyocyte proliferation, we examined the expression of cyclins and CDKs during normal cardiac development.
Kang, MJ +4 more
openaire +3 more sources
CRL4(AMBRA1) is a master regulator of D-type cyclins [PDF]
, 2021 D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer(1), but the mechanisms that regulate their turnover are still being debated(2,3).
Francesco and Cecconi
core +3 more sources
Frontiers in Veterinary Science, 2022 Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah +6 more
doaj +1 more source