Results 11 to 20 of about 33,178 (262)
Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin–cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
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Frontiers in Plant Science, 2023 IntroductionThe leaf, the main product organ, is an essential factor in determining the Chinese cabbage growth, yield and quality.MethodsTo explore the regulatory mechanism of leaf size development of Chinese cabbage, we investigated the leaf size ...
Lixia Wang +11 more
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Cells, 2022 Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While gene-wide association studies and next generation sequencing analyses have identified molecular
Cristina Di Giorgio +16 more
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Plasticity of mitotic cyclins in promoting the G2–M transition [PDF]
Journal of Cell BiologyRandy Y C Poon, Ma Hoi Tang, Ho Wai Lau
exaly +2 more sources
Living with or without cyclins and cyclin-dependent kinases [PDF]
Genes & Development, 2004 Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. Studies performed over more than a decade have supported the view that these holoenzymes are important, if not ...
Charles J, Sherr, James M, Roberts
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Cyclin E, a redundant cyclin in breast cancer [PDF]
Proceedings of the National Academy of Sciences, 1996 Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in ...
J, Gray-Bablin +5 more
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Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas
Archives of Pathology & Laboratory Medicine, 2000 Abstract Background. —Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the ...
K, Allan +4 more
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Cyclin C: The Story of a Non-Cycling Cyclin [PDF]
Biology, 2019 The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek +8 more
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Frontiers in Oncology, 2020 Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit ...
Gregory R. Kardos +15 more
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BMC Research Notes, 2009 Background The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered regulation of the cell cycle. Little
Collan Yrjö +6 more
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