Results 11 to 20 of about 40,343 (298)

The Less Known Cyclins—Uncovered

Applied Sciences, 2021
Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle ...
Agnieszka Żuryń, Aleksandra Opacka, Adrian Krajewski, Wioletta Zielińska, Alina Grzanka   +4 more
doaj   +2 more sources

Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. [PDF]

PLoS Pathogens, 2012
Gammaherpesvirus cyclins have expanded biochemical features relative to mammalian cyclins, and promote infection and pathogenesis including acute lung infection, viral persistence, and reactivation from latency.
Katherine S Lee, Andrea L Suarez, David J Claypool, Taylor K Armstrong, Erin M Buckingham, Linda F van Dyk   +5 more
doaj   +2 more sources

Cell cyclins: triggering elements of cancer or not? [PDF]

World Journal of Surgical Oncology, 2010
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the
Pateras Ioannis, Alexiou Ioannis, Xiromeritis Konstantinos, Karaiskos Ioannis, Palla Victoria, Stamatakos Michael, Kontzoglou Konstantinos   +6 more
doaj   +4 more sources

Sumoylation of cyclin and its therapeutic potential for cancer [PDF]

Animal Cells and Systems
The precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
doaj   +2 more sources

Whole-Genome Analysis of the Cell Cycle Regulators in Soybean: Evolution, Expansion, and Functional Implications [PDF]

Biology
Cyclin-dependent kinases (CDKs) and cyclins are master regulators of the cell cycle, playing critical roles in plant growth, development, and stress responses.
Qianru Jia, Jinghui Shi, Rui Wang, Xiaoqi He, Binhui Guo, Guanglong Zhu, Li Song   +6 more
doaj   +2 more sources

Analysis of cyclins A, B1, D1 and E in breast cancer in relation to tumour grade and other prognostic factors

BMC Research Notes, 2009
Background The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered regulation of the cell cycle. Little
Collan Yrjö, Vahlberg Tero, Palokangas Tuire, Söderström Mirva, Boström Pia, Carpen Olli, Hirsimäki Pirkko   +6 more
doaj   +2 more sources

Cyclins and Cyclin Dependent Kinases during Cardiac Development

Molecules and Cells, 1997
The molecular mechanisms that regulate the cardiomyocyte cell cycle and its terminal differentiation remain largely unknown. To determine which cyclins or cyclin dependent kinases (CDKs) are important for cardiomyocyte proliferation, we examined the expression of cyclins and CDKs during normal cardiac development.
Kang, MJ, Kim, JS, Chae, SW, Koh, KN, Koh, GY Koh, Gou Young   +4 more
core   +4 more sources

Bombyx mori p38 MAPK Regulates Cell Cycle Progression and Silk Gland Endoreplication via Interaction with Cell Cycle Genes [PDF]

Insects
The cell cycle is a fundamental biological process indispensable for life, and its orderly progression is governed by a complex signaling network. Although the p38 MAPK pathway plays important roles in regulating cell proliferation across metazoans, its ...
Lanxing Wang, Yanbi Long, Siyi Wei, Keqin Ding, Mingli Zhang, Yan Zhu, Zhanqi Dong, Cheng Lu, Peng Chen, Minhui Pan   +9 more
doaj   +2 more sources

In vivo assessment of simultaneous G1 cyclins silencing by a tumor-specific bidirectional promoter on the mammary tumor in nude mice

Frontiers in Veterinary Science, 2022
Dysregulation of G1 cyclins (cyclins D1 A and E) expression contributes to the loss of standard cell cycle control during tumorigenesis. This study aims to evaluate the inhibitory effect of G1 cyclins in nude mice.
Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T. Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi, Majid Shahbazi   +6 more
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CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source