Results 31 to 40 of about 40,343 (298)

Overexpression of Cyclin A and Cyclin B1Proteins in Astrocytomas

Archives of Pathology & Laboratory Medicine, 2000
Abstract Background. —Cyclins are proteins that are expressed during the progression of a normal cell through the cell cycle. In a number of cancers, overexpression of cyclin A and cyclin B1 proteins has been reported, and in some instances the levels of expression correlated well with the ...
K, Allan, R C, Jordan, L C, Ang, M, Taylor, B, Young   +4 more
openaire   +2 more sources

Cyclin C: The Story of a Non-Cycling Cyclin [PDF]

Biology, 2019
The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels.
Jan Ježek, Daniel G. J. Smethurst, David C. Stieg, Z. A. C. Kiss, Sara E. Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F. Cooper, Randy Strich   +8 more
openaire   +4 more sources

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Cells, 2022
Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While gene-wide association studies and next generation sequencing analyses have identified molecular
Cristina Di Giorgio, Antonio Lupia, Silvia Marchianò, Martina Bordoni, Rachele Bellini, Carmen Massa, Ginevra Urbani, Rosalinda Roselli, Federica Moraca, Valentina Sepe, Bruno Catalanotti, Elva Morretta, Maria Chiara Monti, Michele Biagioli, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +16 more
doaj   +1 more source

The crystal structure of cyclin A [PDF]

Structure, 1995
Background: Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs.
NR Brown, Martin Noble, Jane Endicott, EF Garman, S Wakatsuki, E Mitchell, B Rasmussen, T Hunt, LN Johnson   +8 more
openaire   +3 more sources

Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery

Frontiers in Oncology, 2020
Increased protein synthesis is a key process in melanoma, which is regulated by the ALDH18A1 gene encoding pyrroline-5-carboxylate synthase (P5CS). P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit ...
Gregory R. Kardos, Gregory R. Kardos, Gregory R. Kardos, Raghavendra Gowda, Raghavendra Gowda, Raghavendra Gowda, Saketh Sriram Dinavahi, Saketh Sriram Dinavahi, Saketh Sriram Dinavahi, Scot Kimball, Gavin P. Robertson, Gavin P. Robertson, Gavin P. Robertson, Gavin P. Robertson, Gavin P. Robertson, Gavin P. Robertson   +15 more
doaj   +1 more source

Cloning of four cyclins from maize indicates that higher plants have three structurally distinct groups of mitotic cyclins [PDF]

, 1994
While a large number of cyclins have been described in animals and yeasts, very limited information is available regarding cyclins in plants. We describe here the isolation of cDNA clones encoding four putative mitotic cyclins from maize.
Colasanti, J., Colasanti, J., Rime, H., Sundaresan, V., Yuan, Z., Renaudin, J.P., Yuan, Z., Rime, Hélène, Sundaresan, V., Renaudin, J. P., H. Rime, V. Sundaresan, Z. Yuan, J. P. Renaudin, J. Colasanti   +14 more
core   +1 more source

Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes.

PLoS Genetics, 2013
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha   +3 more
doaj   +1 more source

Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features

Folia Histochemica et Cytobiologica, 2012
Cyclins play a fundamental role in the cell cycle. Recent studies have focused on their role in the development of various malignancies. The objective of this study was to evaluate and compare the expression of cyclins A and E in common nevi, dysplastic ...
Ana Alekseenko, Anna Wojas-Pelc, Grzegorz J. Lis, Zdzisław Wiśniowski, Magdalena Czerwińska, Łukasz Niewiara, Jan A. Litwin   +6 more
doaj   +1 more source

The Hunt for Cyclin [PDF]

Cell, 2008
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
openaire   +3 more sources

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +4 more sources