Results 41 to 50 of about 37,065 (297)

Molecular evolution of cyclin proteins in animals and fungi

BMC Evolutionary Biology, 2011
Background The passage through the cell cycle is controlled by complexes of cyclins, the regulatory units, with cyclin-dependent kinases, the catalytic units.
Afonnikov Dmitry A, Turnaev Igor I, Suslov Valentin V, Gunbin Konstantin V, Kolchanov Nikolay A   +4 more
doaj   +1 more source

Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis

Frontiers in Cell and Developmental Biology, 2019
The adult dentate gyrus continuously generates new neurons that endow the brain with increased plasticity, helping to cope with changing environmental and cognitive demands.
Anja Urbach, Otto W. Witte
doaj   +1 more source

Meiotic Cell Cycle Progression in Mouse Oocytes: Role of Cyclins

, 2023
All eukaryotic cells, including oocytes, utilize an engine called cyclin-dependent kinase (Cdk) to drive the cell cycle. Cdks are activated by a co-factor called cyclin, which regulates their activity.
Min Ju Kim, Se Yoon Seong, Eun Kyeong Shin, Jun Hyeon Jo, Min Kook Kang, Seung Jin Han, Chang Geun Lee, Hye Min Kim   +7 more
core   +1 more source

Immunomodulatory Roles of Cell Cycle Regulators

Frontiers in Cell and Developmental Biology, 2019
Core cell cycle regulators, including cyclin-dependent kinases (CDKs), cyclins, and cyclin-dependent kinase inhibitors (CKIs), are known for their well-characterized roles in cell division.
Phatthamon Laphanuwat, Siwanon Jirawatnotai   +1 more
doaj   +1 more source

Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle.

PLoS ONE, 2019
In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. In yeast, the accepted pattern of cyclin waves is
Elisabet Bállega, Reyes Carballar, Bàrbara Samper, Natalia Ricco, Mariana P Ribeiro, Samuel Bru, Javier Jiménez, Josep Clotet   +7 more
doaj   +1 more source

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E [PDF]

Cell, 1999
D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces ...
Geng, Y, Whoriskey, W, Park, M Y, Bronson, R T, Medema, R H, Li, T, Weinberg, R A, Sicinski, P   +7 more
openaire   +4 more sources

Drug-Free Approach To Study the Unusual Cell Cycle of Giardia intestinalis

mSphere, 2017
Giardia intestinalis is a protozoan parasite that causes giardiasis, a form of severe and infectious diarrhea. Despite the importance of the cell cycle in the control of proliferation and differentiation during a giardia infection, it has been difficult ...
Kathleen Horlock-Roberts, Chase Reaume, Guillem Dayer, Christine Ouellet, Nicholas Cook, Janet Yee   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cloning of four cyclins from maize indicates that higher plants have three structurally distinct groups of mitotic cyclins

, 1994
While a large number of cyclins have been described in animals and yeasts, very limited information is available regarding cyclins in plants. We describe here the isolation of cDNA clones encoding four putative mitotic cyclins from maize.
Colasanti, J., Colasanti, J., Rime, H., Sundaresan, V., Yuan, Z., Renaudin, J.P., Yuan, Z., Rime, Hélène, Sundaresan, V., Renaudin, J. P.   +9 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source