Results 41 to 50 of about 32,826 (263)
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
A novel function for the mitotic checkpoint protein Mad2p in translation
Molecular & Cellular Oncology, 2018 MAD2L1 (Mitotic Arrest Deficient 2 Like 1), a member of the mitotic checkpoint, maintains the genomic stability by insuring the proper segregation of the sister chromatids. Deregulation of MAD2L1 protein expression is a recurrent feature in cancer cells.
Sophie Gay
doaj +1 more source
Translational control of cyclins
Cell Division, 2011 Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of regulatory mechanisms, permits a prompt response
Lai Ming-Chih, Tarn Woan-Yuh
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Cell Reports, 2020 Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations.
Weiwei Shan +18 more
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Current Issues in Molecular Biology, 2023 The development of K-Ras independence may explain the failure of targeted therapy for pancreatic cancer (PC). In this paper, active N as well as K-Ras was shown in all human cell lines tested.
Robert Ferguson +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Cell Reports, 2020 Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif.
Mihkel Örd +10 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Dynamic expression profiles from static cytometry data: component fitting and conversion to relative, "same scale" values. [PDF]
PLoS ONE, 2012 Cytometry of asynchronous proliferating cell populations produces data with an extractable time-based feature embedded in the frequency of clustered, correlated events.
Jayant Avva +4 more
doaj +1 more source
Cyclin E, a redundant cyclin in breast cancer [PDF]
Proceedings of the National Academy of Sciences, 1996 Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G 1 /S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower ...
J, Gray-Bablin +5 more
openaire +2 more sources