Results 1 to 10 of about 50,772 (264)

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. [PDF]

PLoS ONE, 2012
Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma.
Justina McEvoy, Anatoly Ulyanov, Rachel Brennan, Gang Wu, Stanley Pounds, Jinghui Zhang, Michael A Dyer   +6 more
doaj   +4 more sources

Post-translational modifications on the retinoblastoma protein [PDF]

Journal of Biomedical Science, 2022
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours.
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu   +6 more
doaj   +4 more sources

Retinoblastoma Protein Paralogs and Tumor Suppression [PDF]

Frontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +4 more sources

Update on pathology of retinoblastoma [PDF]

International Journal of Ophthalmology, 2018
Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj   +2 more sources

IL-18 suppresses retinoblastoma growth while concomitantly inducing an inflammation-/stress-associated and immune-remodeling response [PDF]

Cancer Cell International
Retinoblastoma is the most common intraocular malignancy in childhood and remains associated with substantial treatment related morbidity. Interleukin 18 (IL-18) is an immunomodulatory cytokine with context dependent roles in cancer, yet its functional ...
Zide Chen, Wanqian Luo, Dongyang Wei, Qi Wang, Qing Gou, Jiawei Cao, Qicong Mai, Xiumei Chen, Xiaowen Cai, Xiaoming Chen, Jing Zhang   +10 more
doaj   +2 more sources

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Cell Reports, 2023
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio   +10 more
doaj   +1 more source

Bioinformatics analysis of key biomarkers for retinoblastoma

Journal of International Medical Research, 2021
Objective To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database.
Xin-mei Zhao, Yuan-Bin Li, Peng Sun, Ya-di Pu, Meng-jie shan, Yuan-meng Zhang   +5 more
doaj   +1 more source

Knockdown of NRMT enhances sensitivity of retinoblastoma cells to cisplatin through upregulation of the CENPA/Myc/Bcl2 axis

Cell Death Discovery, 2022
Chemotherapy resistance of tumor cells causes failure in anti-tumor therapies. Recently, N-terminal regulator of chromatin condensation 1 methyltransferase (NRMT) is abnormally expressed in different cancers.
Zhongrui Li, Lan Zhang, Dongrui Liu, Zhanghui Yang, Di Xuan, Yi Zhang   +5 more
doaj   +1 more source

Comparison the Influence of Various Intensities of Aerobic Training on the Expression of RBL-1 and RB1 Genes in the Subcutaneous Adipose Tissue of Male Wistar Rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Background and Purpose: One of the most important methods to cope with obesity metabolic disorder is to do exercise activities that are both effective as a prevention and treatment.
Maryam Shavandi, Saeid Naghibi, Mohammad Shariatzadeh Joneydi, Maryam Vatandoust, Ali Zare   +4 more
doaj   +1 more source

Regulation of p14^ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

BMC Cancer, 2012
Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss of the RB1 tumor suppressor gene, TP53 mutations have not been found.
To Kwong-Him, Pajovic Sanja, Gallie Brenda L, Thériault Brigitte L   +3 more
doaj   +1 more source