Results 31 to 40 of about 50,772 (264)

Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility

Frontiers in Endocrinology, 2022
The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to
Juho-Antti Mäkelä, Jorma Toppari, Jorma Toppari, Jorma Toppari   +3 more
doaj   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining.

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Current Assessment and Management of Retinoblastoma

Clinical Pediatric Hematology-Oncology, 2019
Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment.
Hee Won Chueh
doaj   +1 more source

Protein-protein interaction in retinoblastoma

, 2019
Protein-protein interaction in retinoblastomaThe most common primary intraocular malignancy in children is retinoblastoma. Retinoblastoma has a prevalence of 2% of all cancers diagnosed in children younger than 15. 3 out of 4 children have the disease in
Sarah Hajighadimi (5959262), Rosalind Silverman (5253824), Lorelei Silverman (5205368)   +2 more
core   +1 more source

A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal.

PLoS ONE, 2011
Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 novel
Nadia Korfali, Vlastimil Srsen, Martin Waterfall, Dzmitry G Batrakou, Vanja Pekovic, Christopher J Hutchison, Eric C Schirmer   +6 more
doaj   +1 more source

Insights from mouse models into human retinoblastoma

Cell Division, 2008
Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the ...
MacPherson David
doaj   +1 more source

The retinoblastoma protein: multitasking to suppress tumorigenesis [PDF]

Molecular & Cellular Oncology, 2015
Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and ...
Vormer, Tinke L., Hansen, Jacob B., Riele, Hein te   +2 more
openaire   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest

, 2015
TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R, Harrison, David J, Sheahan, Sharon, Bellamy, Christopher O, Prost, Sandrine   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source