Results 31 to 40 of about 3,403,478 (241)

Guidelines for imaging retinoblastoma: imaging principles and MRI standardization [PDF]

, 2011
Retinoblastoma is the most common intraocular tumor in children. The diagnosis is usually established by the ophthalmologist on the basis of fundoscopy and US.
Sophia Göricke, Rodjan, F., Philippe Maeder, Jonas A. Castelijns, de Graaf, P., Maeder, P., Paolo Galluzzi, Pim de Graaf, Goricke, S., Castelijns, J.A., Hervé J. Brisse, Graaf, P. de, Galluzzi, P., null null, Firazia Rodjan, Brisse, H.J.   +15 more
core   +1 more source

Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility

Frontiers in Endocrinology, 2022
The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to
Juho-Antti Mäkelä, Jorma Toppari, Jorma Toppari, Jorma Toppari   +3 more
doaj   +1 more source

Current Assessment and Management of Retinoblastoma

Clinical Pediatric Hematology-Oncology, 2019
Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment.
Hee Won Chueh
doaj   +1 more source

Protein-protein interaction in retinoblastoma

, 2019
Protein-protein interaction in retinoblastomaThe most common primary intraocular malignancy in children is retinoblastoma. Retinoblastoma has a prevalence of 2% of all cancers diagnosed in children younger than 15. 3 out of 4 children have the disease in
Sarah Hajighadimi (5959262), Rosalind Silverman (5253824), Lorelei Silverman (5205368)   +2 more
core   +1 more source

A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal.

PLoS ONE, 2011
Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 novel
Nadia Korfali, Vlastimil Srsen, Martin Waterfall, Dzmitry G Batrakou, Vanja Pekovic, Christopher J Hutchison, Eric C Schirmer   +6 more
doaj   +1 more source

Insights from mouse models into human retinoblastoma

Cell Division, 2008
Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the ...
MacPherson David
doaj   +1 more source

Sporadic Retinal Astrocytic Hamartoma Mimicking Retinoblastoma in a Child: A Case Report and Literature Review. [PDF]

Clin Case Rep
ABSTRACT Retinal astrocytichamartoma (RAH) is a rare benign glial neoplasm most commonly associated with tuberous sclerosis complex (TSC). Sporadic cases, occurring in the absence of systemic phakomatosis, are uncommon and may closely mimic retinoblastoma, particularly when presenting with a calcified intraocular mass, creating a diagnostic challenge ...
Gurmu MW, Negash S, Mohammed A, Alemu H, Hordofa DF, Abere M, Million L, Mezgebu E.   +7 more
europepmc   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source