Results 31 to 40 of about 3,600,316 (189)
Retinoblastoma Protein Paralogs and Tumor Suppression
Frontiers in Genetics, 2022 The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
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Molecular Biology of Retinoblastoma
, 2015 The molecular biology of retinoblastoma has led to a revolution in our understanding of cancer biology. This chapter reviews the discovery and subsequent elucidation of RB1, the first tumor suppressor gene, and its protein product, Rb.
Walter, Scott D +3 more
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Frontiers in Endocrinology, 2022 The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to
Juho-Antti Mäkelä +3 more
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Protein-protein interaction in retinoblastoma
, 2019 Protein-protein interaction in retinoblastomaThe most common primary intraocular malignancy in children is retinoblastoma. Retinoblastoma has a prevalence of 2% of all cancers diagnosed in children younger than 15. 3 out of 4 children have the disease in
Sarah Hajighadimi (5959262) +2 more
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Current Assessment and Management of Retinoblastoma
Clinical Pediatric Hematology-Oncology, 2019 Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment.
Hee Won Chueh
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PLoS ONE, 2011 Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 novel
Nadia Korfali +6 more
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Regulation of flowering time by FVE, a retinoblastoma-associated protein
, 2004 The initiation of flowering in plants is controlled by environmental and endogenous signals1, 2. Molecular analysis of this process in Arabidopsis thaliana indicates that environmental control is exerted through the photoperiod and vernalization pathways,
Jarillo, J.A. +4 more
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Insights from mouse models into human retinoblastoma
Cell Division, 2008 Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the ...
MacPherson David
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The Role of p53 Protein Expression in Retinoblastoma [PDF]
, 2016 This study was undertaken to demonstrate the expression of p53 in retinoblastoma. Thirty three retinoblastoma tissue samples of intratumoral retinoblastoma were tested with SDS-PAGE to find the expression of retinoblastoma protein, followed by Western ...
Aulanni’am +4 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source