Results 41 to 50 of about 3,403,478 (241)

The retinoblastoma protein: multitasking to suppress tumorigenesis [PDF]

Molecular & Cellular Oncology, 2015
Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and ...
Vormer, Tinke L., Hansen, Jacob B., Riele, Hein te   +2 more
openaire   +4 more sources

RBBP8 (retinoblastoma binding protein 8) [PDF]

, 2009
Review on RBBP8 (retinoblastoma binding protein 8), with data on DNA, on the protein encoded, and where the gene is ...
Chinnadurai, G, Subramanian, T, Vijayalingam, S   +2 more
core   +1 more source

A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions

Cancer Cell International, 2010
Background The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, LXCXE, on the viral protein and a ...
Demone Jordan, Francis Sarah M, Henley Shauna A, Ainsworth Peter, Dick Frederick A   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

RBBP7 (retinoblastoma binding protein 7) [PDF]

, 2010
Review on RBBP7 (retinoblastoma binding protein 7), with data on DNA, on the protein encoded, and where the gene is ...
Sinha, N, R Tamuli, Tamuli, R, N Sinha
core   +1 more source

Molecular Biology of Retinoblastoma

The molecular biology of retinoblastoma has led to a revolution in our understanding of cancer biology. This chapter reviews the discovery and subsequent elucidation of RB1, the first tumor suppressor gene, and its protein product, Rb.
Walter, Scott D, Harbour, J. William
core   +2 more sources

Downregulation of miR-211-5p Promotes Carboplatin Resistance in Human Retinoblastoma Y79 Cells by Affecting the GDNF–LIF Interaction

Frontiers in Oncology, 2022
PurposeTo investigate the role of the miR-211-5p-GDNF signaling pathway in carboplatin resistance of retinoblastoma Y79 cells and what factors it may be affected by.MethodsA carboplatin-resistant retinoblastoma cell line (Y79R) was established in vitro ...
Ning Ke, Lin Chen, Qing Liu, Haibo Xiong, Xinke Chen, Xiyuan Zhou   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking

Frontiers in Immunology
PurposeRetinoblastoma is the most common intraocular cancer in infants and children, with a significant potential for metastasis. The mini-peptide ribosomal protein L41 (RPL41) has demonstrated extensive antitumor effects in vitro by promoting the ...
Ye Li, Tian Zhan, Tianfu Chen, Qianwen Zhong, Sheng Xiao, Aiyuan Wang, Yisheng Jiao   +6 more
doaj   +1 more source

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene.

PLoS ONE, 2023
The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors.
Mireia Palomar-Siles, Viktor Yurevych, Vladimir J N Bykov, Klas G Wiman   +3 more
doaj   +1 more source