Results 1 to 10 of about 110,059 (157)

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]

BMC Cancer, 2019
Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte, Annette Künkele   +15 more
doaj   +4 more sources

RB1 Sequence Variants in Retinoblastoma: Analysis of RB1 Variants in a Database for Correlation with pRB Protein Domains and Clinical Presentation [PDF]

Biomedicines
Background: Retinoblastoma (RB) is the most common pediatric ocular tumor that occurs due to the biallelic inactivation of the RB1 tumor suppressor gene. RB may be unilateral or bilateral and is hereditary in 50% of cases. An inactivation of the RB1 gene
Nicohol Tovar Martelo, Irene Szijan
doaj   +2 more sources

Living with heritable retinoblastoma and the perceived role of regular follow-up at a retinoblastoma survivorship clinic: ‘That is exactly what I have been missing’

BMJ Open Ophthalmology, 2021
Objective To explore living with heritable retinoblastoma, specifically survivors’ perceived role of regular follow-up at a retinoblastoma survivorship clinic.Methods and analysis Adult survivors of heritable retinoblastoma were recruited from the ...
Stina Lou, Pernille Axel Gregersen, Mikkel Funding, Steen F Urbak, Jan Alsner, Maja H Olsen, Jens Overgaard, Sandra E Staffieri   +7 more
doaj   +1 more source

Incidence and geographic distribution of retinoblastoma in Ethiopia

BMC Ophthalmology, 2023
Introduction Retinoblastoma is the most frequent intraocular malignancy of the eye in children, occurring in early childhood. Based on global estimates, Ethiopia is expected to observe over 200 new retinoblastoma cases per year, however without a cancer ...
Sadik Taju Sherief, Gadisa Asfaw, Aemero Abateneh, Solomon Takewe, Diriba Fufa, Teshager Wondale, Temesgen Takele, Helen Dimaras   +7 more
doaj   +1 more source

Sclero-conjunctival ischaemia secondary to intra-arterial chemotherapy for retinoblastoma

American Journal of Ophthalmology Case Reports, 2020
Purpose: Intra-arterial chemotherapy (IAC), delivered directly to the globe via the internal carotid artery is now an established treatment for retinoblastoma.
Lisa McAnena, Zishan Naeem, Catriona Duncan, Fergus Robertson, Mandeep S. Sagoo, M. Ashwin Reddy   +5 more
doaj   +1 more source

Single-cell transcriptome profiling reveals intratumoural heterogeneity and malignant progression in retinoblastoma

Cell Death and Disease, 2021
Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,
Jie Yang, Yongyun Li, Yanping Han, Yiyi Feng, Min Zhou, Chunyan Zong, Xiaoyu He, Renbing Jia, Xiaofang Xu, Jiayan Fan   +9 more
doaj   +1 more source

Patients, Public and Service Users are Experts by Experience: An Overview from Ophthalmology Research in Canada, UK and Beyond

Ophthalmology and Therapy, 2020
Plain Language Summary Through living with conditions and/or engaging with health and social care services patients, public and service users become experts by experience.
Andrew M. Skilton, Leslie G. Low, Helen Dimaras   +2 more
doaj   +1 more source

Lag time, high-risk histopathological features, metastasis, and survival interrelation in retinoblastoma: a perspective from lower-middle income country [PDF]

International Journal of Ophthalmology, 2022
AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr ...
Purjanto Tepo Utomo, Datu Respatika, Bambang Ardianto, Hanggoro Tri Rinonce, Didik Setyo Heriyanto, Banu Aji Dibyasakti, Irene Titin Darajati, Indra Tri Mahayana, Agus Supartoto   +8 more
doaj   +1 more source

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

Pharmacology Research & Perspectives, 2022
We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li, Zhi Li   +5 more
doaj   +1 more source