Results 41 to 50 of about 66,792 (243)

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Cell Reports, 2023
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio   +10 more
doaj   +1 more source

RB1 Sequence Variants in Retinoblastoma: Analysis of RB1 Variants in a Database for Correlation with pRB Protein Domains and Clinical Presentation

Biomedicines
Background: Retinoblastoma (RB) is the most common pediatric ocular tumor that occurs due to the biallelic inactivation of the RB1 tumor suppressor gene. RB may be unilateral or bilateral and is hereditary in 50% of cases. An inactivation of the RB1 gene
Nicohol Tovar Martelo, Irene Szijan
doaj   +1 more source

Retinoblastoma: A spectrum of manifestations in three cases on B-scan

Indian Journal of Radiology and Imaging, 2007
Retinoblastoma is a primary intraocular neoplasm of childhood, presenting with leukocoria.We present a spectrum of three cases. First two cases are of bilateral retinoblastoma and last case is a retinoblastoma of right eye.
V. D. Aironi, Sonesh Chougule, Suneet Khetarpal, Gopalsingh Bhati   +3 more
doaj   +1 more source

Inhibitory activity of bevacizumab to differentiation of retinoblastoma cells. [PDF]

PLoS ONE, 2012
Vascular endothelial growth factor (VEGF) is a major regulator in retinal and choroidal angiogenesis, which are common causes of blindness in all age groups.
Jang Won Heo, Jin Hyoung Kim, Chang Sik Cho, Hyoung Oh Jun, Dong Hun Kim, Young Suk Yu, Jeong Hun Kim   +6 more
doaj   +1 more source

Retinoblastoma in Calabar Nigeria: An 18-Month Retrospective Review of Clinical Presentation at a Tertiary Eye Center

Nigerian Journal of Medicine, 2022
Background: Retinoblastoma, although rare, is the most frequently occurring primary intraocular tumor of childhood. While a cure is often achieved where appropriate treatment is instituted early in the disease, late presentation often leads to ...
Elizabeth Dennis Nkanga, Iwassam Elemi Agbor, Sunday Nnamdi Okonkwo, Ido Didi Fabian, Ekpereonne Babatunde Esu, Dennis George Nkanga, Friday Akwagiobe Odey, Jacintha Banku Okoi-Obuli   +7 more
doaj   +1 more source

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study

Scientific Reports
MYCN-amplified RB1 wild-type (MYCN amp RB1 +/+) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed
Christiaan M. de Bloeme , Robin W. Jansen, Liesbeth Cardoen, Sophia Göricke, Sabien van Elst, Jaime Lyn Jessen, Aparna Ramasubramanian, Alison H. Skalet, Audra K. Miller, Philippe Maeder, Ogul E. Uner, G. Baker Hubbard, Hans Grossniklaus, H. Culver Boldt, Kim E. Nichols, Rachel C. Brennan, Saugata Sen, Mériam Koob, Selma Sirin, Hervé J. Brisse, Paolo Galluzzi, Charlotte J. Dommering, Matthijs Cysouw, Ronald Boellaard, Josephine C. Dorsman, Annette C. Moll, Marcus C. de Jong, Pim de Graaf, European Retinoblastoma Imaging Collaboration   +28 more
doaj   +1 more source

Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma

EJC Paediatric Oncology, 2023
Introduction: Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality.
Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting, Madlen Reschke, Tobias Kiefer, Anna Hannbücken, Maren Wagemanns, Leyla Jabbarli, Selma Sirin, Regina Wieland, Gudrun Fleischhack, Johannes H. Schulte, Martin Ebinger, Dietmar Lohmann, Bert Müller, Daniela Süsskind, Christoph Schwab, Ines Brecht, Angelika Eggert, Stefan Schönberger, Petra Ritter-Sovinz, Nikolaos Bechrakis, Sophia Göricke, Beate Timmermann, Eva Biewald, Petra Ketteler   +27 more
doaj   +1 more source

Thermotherapy for Retinoblastoma [PDF]

Archives of Ophthalmology, 1999
To evaluate the results of thermotherapy for retinoblastoma.Prospective, nonrandomized analysis of the treatment method.A total of 188 retinoblastomas in 80 eyes of 58 patients who were treated with thermotherapy.Tumor response and ocular adverse effects.Of 188 retinoblastomas treated with thermotherapy, mean tumor base was 3.0 mm and tumor thickness ...
C L, Shields, M C, Santos, W, Diniz, K, Gündüz, G, Mercado, J R, Cater, J A, Shields   +6 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study. [PDF]

To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma.
Uner, O.E., de Graaf, P., Maeder, P., Dorsman, J., Roohollahi, K., Sirin, S., Castelijns, J.A., Cardoen, L., de Bloeme, C.M., Galluzzi, P., Moll, A.C., de Jong, Y., van der Valk, P., Jansen, R.W., Brisse, H.J., Hubbard, G.B., de Jong, M.C., Göricke, S., Grossniklaus, H.   +18 more
core   +1 more source