Results 21 to 30 of about 66,792 (243)

Patients, Public and Service Users are Experts by Experience: An Overview from Ophthalmology Research in Canada, UK and Beyond

Ophthalmology and Therapy, 2020
Plain Language Summary Through living with conditions and/or engaging with health and social care services patients, public and service users become experts by experience.
Andrew M. Skilton, Leslie G. Low, Helen Dimaras   +2 more
doaj   +1 more source

The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries. [PDF]

, 2022
BACKGROUND: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been ...
The Global Retinoblastoma Study Group, Global Retinoblastoma Study Group   +1 more
core   +1 more source

Lag time, high-risk histopathological features, metastasis, and survival interrelation in retinoblastoma: a perspective from lower-middle income country [PDF]

International Journal of Ophthalmology, 2022
AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr ...
Purjanto Tepo Utomo, Datu Respatika, Bambang Ardianto, Hanggoro Tri Rinonce, Didik Setyo Heriyanto, Banu Aji Dibyasakti, Irene Titin Darajati, Indra Tri Mahayana, Agus Supartoto   +8 more
doaj   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Intravitreal melphalan for persistent retinoblastoma vitreous seeds [PDF]

, 2022
A 7-month-old male presented with bilateral retinoblastoma, initially group E OD and group C OS (International Intraocular Retinoblastoma Classification).
Redondo-Villanueva, MJH, Mercado, GJV
core   +1 more source

mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

Pharmacology Research & Perspectives, 2022
We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li, Zhi Li   +5 more
doaj   +1 more source

Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategies

Indian Journal of Ophthalmology, 2023
Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular tumor worldwide. Despite tremendous breakthroughs in our understanding of the fundamental mechanisms that regulate progression of retinoblastoma, the ...
Shruti Rathore, Aman Verma, Ria Ratna, Navjot Marwa, Yagya Ghiya, Santosh G Honavar, Anil Tiwari, Sima Das, Akhil Varshney   +8 more
doaj   +1 more source

Bone metastasis of retinoblastoma five years after primary treatment

American Journal of Ophthalmology Case Reports, 2020
Purpose: Histopathological, immunohistochemistry- and molecular pathology-based diagnostics to distinguish metastasis of retinoblastoma from subsequent primary malignancy in patients with heritable retinoblastoma.
Saskia C. Ting, Tobias Kiefer, Karoline Ehlert, Sophia L. Goericke, Raoul Hinze, Petra Ketteler, Nikolaos E. Bechrakis, Hans-Ulrich Schildhaus   +7 more
doaj   +1 more source

Longer Lag Time in Early-Stage Retinoblastoma

Folia Medica Indonesiana, 2022
Highlights: • Patients with IRSS I stage have the longest lag time than IVB stage. • Lag time is no significant with stage retinoblastoma.   Abstract: Retinoblastoma is a rare neoplasm disease that occurs in children, generally under the age of ...
Anindya Citra, Budi Utomo, Hendrian Dwikoloso Soebagjo   +2 more
doaj   +1 more source

Molecular Biology of Retinoblastoma [PDF]

The molecular biology of retinoblastoma has led to a revolution in our understanding of cancer biology. This chapter reviews the discovery and subsequent elucidation of RB1, the first tumor suppressor gene, and its protein product, Rb.
Walter, Scott D, Harbour, J. William
core   +3 more sources