Results 31 to 40 of about 110,178 (262)

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

A rare case of adult onset retinoblastoma

Oman Journal of Ophthalmology, 2011
Retinoblastoma usually manifests before five years of age. Retinoblastoma in an adult is extremely rare. Twenty-three cases of retinoblastoma in adults 20 years or older have been reported in world literature.
Sunil Kumar Singh, Dipankar Das, Harsha Bhattacharjee, Jyotirmay Biswas, Ganesh Kuri, Kasturi Bhattacharjee, Hemlata Deka, Akshay Chandra Deka   +7 more
doaj   +1 more source

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Cell Reports, 2023
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio   +10 more
doaj   +1 more source

Retinoblastoma: A spectrum of manifestations in three cases on B-scan

Indian Journal of Radiology and Imaging, 2007
Retinoblastoma is a primary intraocular neoplasm of childhood, presenting with leukocoria.We present a spectrum of three cases. First two cases are of bilateral retinoblastoma and last case is a retinoblastoma of right eye.
V. D. Aironi, Sonesh Chougule, Suneet Khetarpal, Gopalsingh Bhati   +3 more
doaj   +1 more source

Inhibitory activity of bevacizumab to differentiation of retinoblastoma cells. [PDF]

PLoS ONE, 2012
Vascular endothelial growth factor (VEGF) is a major regulator in retinal and choroidal angiogenesis, which are common causes of blindness in all age groups.
Jang Won Heo, Jin Hyoung Kim, Chang Sik Cho, Hyoung Oh Jun, Dong Hun Kim, Young Suk Yu, Jeong Hun Kim   +6 more
doaj   +1 more source

Retinoblastoma in Calabar Nigeria: An 18-Month Retrospective Review of Clinical Presentation at a Tertiary Eye Center

Nigerian Journal of Medicine, 2022
Background: Retinoblastoma, although rare, is the most frequently occurring primary intraocular tumor of childhood. While a cure is often achieved where appropriate treatment is instituted early in the disease, late presentation often leads to ...
Elizabeth Dennis Nkanga, Iwassam Elemi Agbor, Sunday Nnamdi Okonkwo, Ido Didi Fabian, Ekpereonne Babatunde Esu, Dennis George Nkanga, Friday Akwagiobe Odey, Jacintha Banku Okoi-Obuli   +7 more
doaj   +1 more source

Questionnaire study to gain an insight into the manufacturing and fitting process of artificial eyes in children: an ocularist perspective [PDF]

, 2016
Purpose To gain an insight into the manufacturing and fitting of artificial eyes in children and potential improvements to the process. Method An online qualitative survey was distributed to 39 ocularists/prosthetists in Europe and Canada ...
A Clarke, A Fink, AA Ayanniyi, Bryce Dyer, D Raizada, E McColl, G Wu, GK Goel, H Jansen, HB McBain, Holly Chinnery, Karen Rees, N Starling, P Evans, P Garg, PD Converse, R Bibb, RK Gupta, S Li, S Sofaer, S Sofaer, Siamak Noroozi, Simon B. N. Thompson, SM Shortell, SR Shaikh, TJ Hoff, VC Braun, VW Willard, W Phillips, Y Bi   +29 more
core   +2 more sources

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study

Scientific Reports
MYCN-amplified RB1 wild-type (MYCN amp RB1 +/+) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed
Christiaan M. de Bloeme , Robin W. Jansen, Liesbeth Cardoen, Sophia Göricke, Sabien van Elst, Jaime Lyn Jessen, Aparna Ramasubramanian, Alison H. Skalet, Audra K. Miller, Philippe Maeder, Ogul E. Uner, G. Baker Hubbard, Hans Grossniklaus, H. Culver Boldt, Kim E. Nichols, Rachel C. Brennan, Saugata Sen, Mériam Koob, Selma Sirin, Hervé J. Brisse, Paolo Galluzzi, Charlotte J. Dommering, Matthijs Cysouw, Ronald Boellaard, Josephine C. Dorsman, Annette C. Moll, Marcus C. de Jong, Pim de Graaf, European Retinoblastoma Imaging Collaboration   +28 more
doaj   +1 more source

Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma

EJC Paediatric Oncology, 2023
Introduction: Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality.
Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting, Madlen Reschke, Tobias Kiefer, Anna Hannbücken, Maren Wagemanns, Leyla Jabbarli, Selma Sirin, Regina Wieland, Gudrun Fleischhack, Johannes H. Schulte, Martin Ebinger, Dietmar Lohmann, Bert Müller, Daniela Süsskind, Christoph Schwab, Ines Brecht, Angelika Eggert, Stefan Schönberger, Petra Ritter-Sovinz, Nikolaos Bechrakis, Sophia Göricke, Beate Timmermann, Eva Biewald, Petra Ketteler   +27 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes, Aoyama, Barak, Bressac, Bressac, Buetow, Caselmann, Challen, Colombo, Donehower, Fields, Finlay, Foster, Halevy, Hsu, Jenkins, Kastan, Kekulé, Kew, Kress, Lane, Laurent-Puig, Lilleberg, Livingstone, Ludlow, Malkin, Marshall, Meyer, Meyer, Mueller, Murakami, Nigro, Ozturk, Raycroft, Sarnow, Slagle, Srivastava, Sturzbecher, Taylor, Wolfgang H. Caselmann, Wollersheim   +40 more
core   +1 more source