Results 51 to 60 of about 66,792 (243)

Current therapy and recent advances in the management of retinoblastoma

Indian Journal of Medical and Paediatric Oncology, 2012
Retinoblastoma is the most common intraocular malignancy in children. The survival of retinoblastoma patients and visual outcome has improved dramatically in the developed world.
Rachna Meel, Venkatraman Radhakrishnan, Sameer Bakhshi   +2 more
doaj   +1 more source

Characterization of the Portuguese population diagnosed with retinoblastoma

Scientific Reports, 2022
The purpose of this study is to characterize demographically and genetically the Portuguese population with retinoblastoma; to report the clinical stage at presentation and its impact on survival and ocular preservation rate and, finally, to assess the ...
Guilherme Castela, Joana Providência, Madalena Monteiro, Sonia Silva, Manuel Brito, Joaquim Sá, Barbara Oliveiros, Joaquim Neto Murta, Zelia Correa, Miguel Castelo Branco   +9 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Recent Trends in the Management of Retinoblastoma [PDF]

, 2015
Retinoblastoma is the most common intraocular malignancy of childhood. Significant progress has been made in the past few years in the management of retinoblastoma. Thus, the patients’ survival and ocular salvage rates have shown marked improvement. The
Derda Özer, Ozer, Derda, Samuray Tuncer, Tuncer, Samuray   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma. [PDF]

To assess the diagnostic accuracy of nerve thickening on MRI to predict early-stage postlaminar optic nerve invasion (PLONI) in retinoblastoma. Furthermore, this study aimed to incorporate measurements into a multiparametric model for radiological ...
Koob, M., Grauwels, STL, de Graaf, P., Maeder, P., Sirin, S., Cardoen, L., de Bloeme, C.M., Galluzzi, P., Moll, A.C., van Elst, S., Ketteler, P., van der Valk, P., Jansen, R.W., Brisse, H.J., de Jong, M.C., Göricke, S.   +15 more
core   +1 more source

DILEMA DALAM MANAJEMEN RETINOBLASTOMA

Majalah Kedokteran Andalas, 2014
Abstrak:Retinoblastoma merupakan keganasan intraokular tersering pada anak-anak. Deteksi dini memegang peranan penting dalam manajemen retinoblastoma karena sangat mempengaruhi prognosa.
Ardizal Rahman
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Follow-up of Cystic Pineal Glands in Retinoblastoma Patients Does Not Increase Detection of Pineal Trilateral Retinoblastoma. [PDF]

To evaluate the effectiveness of baseline screening and follow-up with magnetic resonance imaging (MRI) for detecting trilateral retinoblastoma (TRb) and assessing the risk of TRb development. Prospective multicenter cohort study.
Casseri, T., Koob, M., Pieperjohanns, D., de Haan, J., Gironi, F., de Graaf, P., Maeder, P., Sirin, S., de Bloeme, C.M., Galluzzi, P., Moll, A.C., Ketteler, P., Jansen, R.W., Pasca, A., de Jong, M.C., Göricke, S.   +15 more
core   +1 more source

MiR-613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5

Tumor Biology, 2017
Retinoblastoma is a common intraocular malignancy that occurs during childhood. MicroRNAs play critical roles in the regulation of retinoblastoma initiation and progression, and aberrant expression of miR-613 had been reported in various types of cancer.
Yiting Zhang, Xinyue Zhu, Xiaomin Zhu, Yan Wu, Yajun Liu, Borui Yao, Zhenping Huang   +6 more
doaj   +1 more source