Results 51 to 60 of about 3,403,478 (241)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Gutierrez-Marcos, José F., Liliana M Costa, Costa Liliana M, Costa, Liliana M., José F Gutierrez-Marcos, Gutierrez-Marcos José F   +5 more
core   +1 more source

Magnetic Resonance Imaging Can Reliably Differentiate Optic Nerve Inflammation from Tumor Invasion in Retinoblastoma with Orbital Cellulitis [PDF]

, 2022
PURPOSE To investigate the prevalence and magnetic resonance imaging (MRI) phenotype of retinoblastoma-associated orbital cellulitis. Additionally, this study aimed to identify postlaminar optic nerve enhancement (PLONE) patterns differentiating ...
Sirin, Selma, Biewald, E., de Jong, Marcus C, Maeder, Philippe, Sen, Saugata, Sen, S., de Graaf, P., Castelijns, Jonas A, de Graaf, Pim, Cardoen, Liesbeth, Castelijns, J.A., van der Heide, Sophie, Cardoen, L., Galluzzi, P., Moll, A.C., Jansen, R.W., Brisse, H.J., Galluzzi, Paolo, European Retinoblastoma Imaging Collaboration, Jansen, Robin W, Brisse, Hervé J, Biewald, Eva, Maeder, P., Moll, Annette C, Sirin, S., de Bloeme, C.M., Göricke, Sophia, van der Heide, S., van der Valk, P., van der Valk, Paul, de Jong, M.C., Göricke, S., de Bloeme, Christiaan M   +32 more
core   +1 more source

Aspects of Diagnosis and Treatment of Retinoblastoma in Mongolia

Central Asian Journal of Medical Sciences, 2018
Objectives: To describe the clinical characteristics and the treatment outcome of retinoblastoma in Mongolian children. Methods: Data of all children diagnosed with retinoblastoma at the National Center for Maternal and Child Health of Mongolia from 1987
Tsengelmaa Chuluunbat, Bayalag Munkhuu, Uranchimeg Bazarsad, Altankhuu Molom, Baasankhuu Jamiyanjav   +4 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Evidence for a mitochondrial localization of the retinoblastoma protein [PDF]

BMC Cell Biology, 2009
Abstract Background The retinoblastoma protein (Rb) plays a central role in the regulation of cell cycle, differentiation and apoptosis. In cancer cells, ablation of Rb function or its pathway is a consequence of genetic inactivation, viral oncoprotein binding or deregulated hyperphosphorylation.
Feracatu, I., Le Foch, N., Bergeaud, M., Rodriguez-Enfedaque, A., Rincheval, V., Oliver, L., Valette, F., Mignotte, B., Vayssiere, Jl   +8 more
openaire   +5 more sources

Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province

Medical Journal of Babylon, 2020
Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes.
Dalya Shakir Al-Owaidi, Moaed E Algazally, Alaa Sadeq Alawaad   +2 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

Frontiers in Chemical Biology
IntroductionThe retinoblastoma protein (pRb) is a key regulator of the cell cycle that suppresses cell proliferation by binding to E2F transcription factors.
Carla Luciana Padilla Franzotti, Carla Luciana Padilla Franzotti, Nicolas Palopoli, Nicolas Palopoli, Juliana Palma, Juliana Palma, Gustavo Pierdominici-Sottile, Gustavo Pierdominici-Sottile   +7 more
doaj   +1 more source