Results 51 to 60 of about 50,772 (264)

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking

Frontiers in Immunology
PurposeRetinoblastoma is the most common intraocular cancer in infants and children, with a significant potential for metastasis. The mini-peptide ribosomal protein L41 (RPL41) has demonstrated extensive antitumor effects in vitro by promoting the ...
Ye Li, Tian Zhan, Tianfu Chen, Qianwen Zhong, Sheng Xiao, Aiyuan Wang, Yisheng Jiao   +6 more
doaj   +1 more source

Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity [PDF]

, 2018
Pocket proteins retinoblastoma (pRb), p107 and p130 are negative regulators of cellular proliferation and multifunctional proteins regulating development, differentiation and chromatin structure.
Chemes, Lucia Beatriz, Gibson, Toby J., González Foutel, Nicolás Sebastián, Palopoli, Nicolás   +3 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Aspects of Diagnosis and Treatment of Retinoblastoma in Mongolia

Central Asian Journal of Medical Sciences, 2018
Objectives: To describe the clinical characteristics and the treatment outcome of retinoblastoma in Mongolian children. Methods: Data of all children diagnosed with retinoblastoma at the National Center for Maternal and Child Health of Mongolia from 1987
Tsengelmaa Chuluunbat, Bayalag Munkhuu, Uranchimeg Bazarsad, Altankhuu Molom, Baasankhuu Jamiyanjav   +4 more
doaj   +1 more source

The Retinoblastoma Protein in Osteosarcomagenesis [PDF]

, 2012
Osteosarcoma is one of the most common primary non-hematologic bone tumors present in both children and adults. The etiology of most cases of osteosarcoma is unknown although a genetic predisposition is suspected. Most osteosarcomas are diagnosed before the age of 20, where the pathology is likely distinct from osteosarcoma diagnosed over the age of 60,
Elizabeth Kong, Philip W.
openaire   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Correlation of serum concentration cyclin-dependent kinase 4 and cyclin-dependent kinase 6 with breast cancer in Babylon province

Medical Journal of Babylon, 2020
Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes.
Dalya Shakir Al-Owaidi, Moaed E Algazally, Alaa Sadeq Alawaad   +2 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Retinoblastoma. Part 1. Clinical presentations and diagnostic tools [PDF]

Клиническая офтальмология, 2020
Retinoblastoma. Part 1. Clinical presentations and diagnostic tools S.V. Ivanova1, S.A. Kuleva1, N.N. Sadovnikova2, M.I. Komissarov2, M.N. Chistyakova2, A.V. Khokhlova1, N.A. Shchegoleva3 1N.N.
S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva   +6 more
doaj  

Bioactive Polymeric Nanoparticles of Moringa oleifera Induced Phyto-Photothermal Sensitization for the Enhanced Therapy of Retinoblastoma

Pharmaceutics, 2023
Treatment of retinoblastoma is limited due to its delayed detection and inaccesbility of drugs to reach the retina crossing the blood-retinal barrier. With the advancements in nanotechnology, photothermal therapy (PTT) employing plasmonic nanomaterials ...
Sushma Venkata Mudigunda, Deepak B. Pemmaraju, Sri Amruthaa Sankaranarayanan, Aravind Kumar Rengan   +3 more
doaj   +1 more source