Results 51 to 60 of about 3,600,316 (189)
Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
wiley +1 more source
Aspects of Diagnosis and Treatment of Retinoblastoma in Mongolia
Central Asian Journal of Medical Sciences, 2018 Objectives: To describe the clinical characteristics and the treatment outcome of retinoblastoma in Mongolian children. Methods: Data of all children diagnosed with retinoblastoma at the National Center for Maternal and Child Health of Mongolia from 1987
Tsengelmaa Chuluunbat +4 more
doaj +1 more source
Evidence for a mitochondrial localization of the retinoblastoma protein [PDF]
BMC Cell Biology, 2009 Abstract Background The retinoblastoma protein (Rb) plays a central role in the regulation of cell cycle, differentiation and apoptosis. In cancer cells, ablation of Rb function or its pathway is a consequence of genetic inactivation, viral oncoprotein binding or deregulated hyperphosphorylation.
Feracatu, I. +8 more
openaire +5 more sources
A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Advanced Science, EarlyView.Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]
, 2010 In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Adriano Ceccarelli +9 more
core +2 more sources
Medical Journal of Babylon, 2020 Objectives: The goal of this study to estimate the correlation between breast cancer and cyclin-dependent kinase 4 (CDK4)\CDK6 enzyme concentrations in the occurrence of breast cancer and breast cancer subtypes.
Dalya Shakir Al-Owaidi +2 more
doaj +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
, 1999 Review on RB1 (retinoblastoma), with data on DNA, on the protein encoded, and where the gene is ...
DR Lohmann, Lohmann, DR
core +1 more source
, 2012 Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome.
core +2 more sources
Frontiers in Chemical BiologyIntroductionThe retinoblastoma protein (pRb) is a key regulator of the cell cycle that suppresses cell proliferation by binding to E2F transcription factors.
Carla Luciana Padilla Franzotti +7 more
doaj +1 more source