Results 71 to 80 of about 3,600,316 (189)

Retinoblastoma tumor suppressor protein is not a risk factor for the location of condyloma acuminatum among adults

Universa Medicina
Background Condylomata acuminata (CA) are sexually transmitted infections primarily caused by low-risk HPV types 6 and 11. Retinoblastoma protein (pRb) interacts with HPV oncoproteins, leading to destabilization, genomic instability, and carcinogenesis ...
Pratiwi Prasetya Primisawitri, ⁠Nurrachmat Mulianto, Endra Yustin Ellistasari, Eti Poncorini, ⁠⁠Harijono Kariosentono, Suci Widhiati, Brian Wasita, Novan Adi Setyawan, Muhammad Yurizar Yudhistira   +8 more
doaj   +1 more source

Aberrant cytoplasmic accumulation of retinoblastoma protein in basal cells may lead to increased survival in malignant canine mammary tumours

Veterinární Medicína, 2014
The retinoblastoma susceptibility gene RB-1 is a tumour suppressor gene that encodes a protein (Rb) that regulates the transition from the G1 phase to the S phase of the cell cycle. Inactivation of the Rb gene has been shown in a variety of human tumours,
S. Gautam, N.K. Sood, K. Gupta
doaj   +1 more source

Comparison of HPV Antibodies Measured Prior to Diagnosis of Anal, Cervical, Oropharyngeal, Penile and Vaginal Cancers in the HPV Cancer Cohort Consortium

International Journal of Cancer, EarlyView.
ABSTRACT Antibodies against HPV proteins can provide pre‐diagnostic information about cancer development. We described the prevalence of antibodies to proteins of oncogenic HPV types prior to diagnosis of HPV‐related cancers. We analysed pre‐diagnostic blood from 1700 participants with incident HPV‐related cancers (anal = 387, cervical = 274 ...
Justina Ucheojor Onwuka, Marie‐Pierre Nobels, Aimée R. Kreimer, Lea Schroeder, Aida Ferreiro‐Iglesias, Ilir Agalliu, Demetrius Albanes, Qiuyin Cai, Gypsyamber D'Souza, Neal D. Freedman, Graham G. Giles, Allan Hildesheim, Wen‐Yi Huang, Kristian Hveem, Hilde Langseth, Roger L. Milne, Eivind Ness‐Jensen, Nicolas F. Schlecht, Lesley F. Tinker, Giske Ursin, Kala Visvanathan, Sylvia Wassertheil‐Smoller, Stephanie J. Weinstein, Wei Zheng, Mari Nygard, Mattias Johansson, Tim Waterboer, Gary M. Clifford, Hilary A. Robbins   +28 more
wiley   +1 more source

Increasing Familial Retinoblastoma in High-Income Countries despite Stable Overall Incidence, 2017 to 2024. [PDF]

To reassess retinoblastoma (RB) incidence in high-income countries (HICs) participating in the Global Retinoblastoma Study and evaluate temporal changes in the proportion of familial RB between 2017 and 2024. Multicenter repeated cross-sectional study.
Stathopoulos, Christina, Chawla, Bhavna, Al-Jadiry, Mazin Faisal, Dalvin, Lauren A, Bowman, Richard, Fabian, Ido Didi, Benvenuto, Franco, Cassoux, Nathalie, Sandri, Lara, Ademola-Popoola, Dupe S, Chaudhry, Shabana, Susanty, Anne, Essuman, Vera Adobea, Lustig-Barzelay, Yael, Staffieri, Sandra Elfride, Bansal, Rolika, Comsa, Codruta, Global Retinoblastoma Study Group   +17 more
core   +1 more source

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Journal of Neuroinflammation, 2005
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive.
Arendt Thomas, Veerhuis Robert, van Haastert Elise S, Hoozemans Jeroen JM, Scheper Wiep, Eikelenboom Piet, Rozemuller Annemieke JM   +6 more
doaj   +1 more source

Immunolocalization of the retinoblastoma protein in the human eye and in retinoblastoma.

Investigative ophthalmology & visual science, 1994
To determine whether, by employing recent advances in immunocytochemical technique, it is possible to identify reliably the product of the retinoblastoma (RB) susceptibility gene, p110RB1, in formalin-fixed, paraffin-embedded eyes with commercially available primary antibodies.
T M, Nork, L L, Millecchia, G, Poulsen
openaire   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Specific Enzymatic Dephosphorylation of the Retinoblastoma Protein [PDF]

Molecular and Cellular Biology, 1993
The retinoblastoma gene product (RB) undergoes cell cycle-dependent phosphorylation and dephosphorylation. Pulse-chase experiments revealed that the change in RB gel electrophoretic migration which occurs near mitosis is due to enzymatic dephosphorylation (J. W. Ludlow, J. Shon, J. M. Pipas, D. M. Livingston, and J. A. DeCaprio, Cell 60:387-396, 1990).
J W, Ludlow, C L, Glendening, D M, Livingston, J A, DeCarprio   +3 more
openaire   +3 more sources

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Inhibition of retinoblastoma mRNA degradation through Poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia. [PDF]

PLoS ONE, 2014
Berberine is one kind of isoquinoline alkaloid with anti-apoptotic effects on the neurons suffering ischemia. To address the explanation for these activities, the berberine-induced cell cycle arrest during neurons suffering ischemia/reperfusion had been ...
Yu-Shuang Chai, Zhi-Yi Yuan, Fan Lei, Yu-Gang Wang, Jun Hu, Feng Du, Xi Lu, Jing-Fei Jiang, Dong-Ming Xing, Li-Jun Du   +9 more
doaj   +1 more source