Results 71 to 80 of about 50,772 (264)

Immunolocalization of the retinoblastoma protein in the human eye and in retinoblastoma.

Investigative ophthalmology & visual science, 1994
To determine whether, by employing recent advances in immunocytochemical technique, it is possible to identify reliably the product of the retinoblastoma (RB) susceptibility gene, p110RB1, in formalin-fixed, paraffin-embedded eyes with commercially available primary antibodies.
T M, Nork, L L, Millecchia, G, Poulsen
openaire   +1 more source

The Retinoblastoma Protein Is Linked to the Activation of Ras [PDF]

Molecular and Cellular Biology, 1999
The inner membrane-bound protein Ras integrates various extracellular signals that are subsequently communicated from the cytoplasm to the nucleus via the Raf/MEK/MAPK cascade. Here we show that the retinoblastoma protein pRb, previously reported to be a nuclear target of this pathway, can in turn influence the activation state of Ras.
K Y, Lee, M H, Ladha, C, McMahon, M E, Ewen   +3 more
openaire   +2 more sources

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
Alaol Kabir, Kabir, Alaol, Sakib, Kazi, Kazi Sakib, Hossain, Alamgir, Islam, Md Saiful, Islam, Md. Saiful, Hossain, Md Alamgir, Md. Alamgir Hossain, Md. Saiful Islam   +9 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Retinoblastoma [PDF]

, 2012
Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome.

core   +2 more sources

Retinoblastoma tumor suppressor protein is not a risk factor for the location of condyloma acuminatum among adults

Universa Medicina
Background Condylomata acuminata (CA) are sexually transmitted infections primarily caused by low-risk HPV types 6 and 11. Retinoblastoma protein (pRb) interacts with HPV oncoproteins, leading to destabilization, genomic instability, and carcinogenesis ...
Pratiwi Prasetya Primisawitri, ⁠Nurrachmat Mulianto, Endra Yustin Ellistasari, Eti Poncorini, ⁠⁠Harijono Kariosentono, Suci Widhiati, Brian Wasita, Novan Adi Setyawan, Muhammad Yurizar Yudhistira   +8 more
doaj   +1 more source

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Journal of Neuroinflammation, 2005
Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive.
Arendt Thomas, Veerhuis Robert, van Haastert Elise S, Hoozemans Jeroen JM, Scheper Wiep, Eikelenboom Piet, Rozemuller Annemieke JM   +6 more
doaj   +1 more source

Regulation of the retinoblastoma proteins by the human herpesviruses [PDF]

Cell Division, 2009
Viruses are obligate intracellular parasites that alter the environment of infected cells in order to replicate more efficiently. One way viruses achieve this is by modulating cell cycle progression. The main regulators of progression out of G0, through G1, and into S phase are the members of the retinoblastoma (Rb) family of tumor suppressors.
Kalejta Robert F, Hume Adam J
openaire   +3 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The Role of p53 Protein Expression in Retinoblastoma [PDF]

, 2016
This study was undertaken to demonstrate the expression of p53 in retinoblastoma. Thirty three retinoblastoma tissue samples of intratumoral retinoblastoma were tested with SDS-PAGE to find the expression of retinoblastoma protein, followed by Western ...
Aulanni’am, Sumitro, Sutiman Bambang, Soebagjo, Hendrian Dwikoloso, Fatmariyanti, Susy, Lutfi, Delfitri   +4 more
core