Results 91 to 100 of about 50,772 (264)

Protein-Protein Interaction Network Study Reveals New Possible Endocrine Disrupting Chemicals (EDC) ‘ Impact on Retinoblastoma

, 2020
: Background: Retinoblastoma (RB) is a retinal-derived embryonic tumor. The illness severity at the time of presentation affects survival and preserves eyesight.
Samadi, Sina, Maleki, Masoud, Khalili, Ali, Rezapour, Ali, MotieGhader, Habib, Yari, Amirhossein   +5 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

Cell Reports, 2017
The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We
Shonagh Munro, Edward S. Hookway, Melanie Floderer, Simon M. Carr, Rebecca Konietzny, Benedikt M. Kessler, Udo Oppermann, Nicholas B. La Thangue   +7 more
doaj   +1 more source

The role of A-Type lamins and LAP2a in cellular ageing of human fibroblasts in vitro [PDF]

, 2005
Mutations in LMNA gene have been linked to a number of age-related tissue-specific diseases and premature ageing syndromes termed laminopathies. The finding that A- type lamins affect longevity and maintenance of a number of somatic tissues makes them ...
PekovicÌ, Vanja, Peković, Vanja
core  

A gender-specific retinoblastoma-related protein in Volvox carteri implies a role for the retinoblastoma protein family in sexual development

, 2008
Kianianmomeni A, Nematollahi G, Hallmann A. A gender-specific retinoblastoma-related protein in Volvox carteri implies a role for the retinoblastoma protein family in sexual development. Plant Cell.
Kianianmomeni, Arash, Hallmann, Armin ; https://orcid.org/, Nematollahi, G.   +2 more
core   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP

Scientific Reports
Retinoblastoma is one of the most common ocular malignancies in children. Bmi-1, a member of the Polycomb group family of transcriptional repressors, is expressed in a variety of tumors.
Qian Li, Te Fu, Ning Wei, Qiaoling Wang, Xin Zhang   +4 more
doaj   +1 more source

Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

eLife, 2013
Skeletal muscle degeneration is a complication arising from a variety of chronic diseases including advanced cancer. Pro-inflammatory cytokine TNF-α plays a pivotal role in mediating cancer-related skeletal muscle degeneration.
Keigo Araki, Keiko Kawauchi, Hiroaki Hirata, Mie Yamamoto, Yoichi Taya   +4 more
doaj   +1 more source

Unraveling the Shared Genetic Architecture and Molecular Mechanisms Linking Cardiovascular Traits and Glaucoma: A Comprehensive Cross‐Trait Analysis

Medicine Advances, EarlyView.
This study investigates the shared genetic architecture between eight cardiovascular traits and glaucoma using comprehensive cross‐trait analysis. We identified 9948 pleiotropic loci, 71 colocalized signals, and 24 shared genes, with BCAS3, BICC1, FAM213A, ITGB5, NUP160, and TNS1 emerging as robust cross‐trait candidates.
Junfei Huang, Zejun Chen, Mengqing Lin, Bingyu Xu, Qiang Liu, Zhengran Li, Jianping Gao, Guoguo Yi, Min Fu   +8 more
wiley   +1 more source

Nanopore Sequencing for HPV in Oropharyngeal Squamous Cell Carcinoma and Benign Tonsil Specimens

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives Human papillomavirus (HPV) accounts for the majority of oropharyngeal squamous cell carcinoma (OPSCC) cases in the United States but understanding the prevalence of high‐risk HPV in oropharyngeal tissue remains poor. We evaluated nanopore sequencing, a novel rapid, and long‐read sequencing platform, on OPSCC tissue and tested it in ...
Mikayla G. Hubbard, Guang‐Sheng Lei, Robert Emerson, Danielle Schreiber, Thomas E. Davis, Diane W. Chen   +5 more
wiley   +1 more source