Results 111 to 120 of about 3,403,478 (241)

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source

IL-18 suppresses retinoblastoma growth while concomitantly inducing an inflammation-/stress-associated and immune-remodeling response

Cancer Cell International
Retinoblastoma is the most common intraocular malignancy in childhood and remains associated with substantial treatment related morbidity. Interleukin 18 (IL-18) is an immunomodulatory cytokine with context dependent roles in cancer, yet its functional ...
Zide Chen, Wanqian Luo, Dongyang Wei, Qi Wang, Qing Gou, Jiawei Cao, Qicong Mai, Xiumei Chen, Xiaowen Cai, Xiaoming Chen, Jing Zhang   +10 more
doaj   +1 more source

Cancer Risk in Marfan Syndrome: A Swedish Population‐Based Cohort Study

International Journal of Cancer, Volume 159, Issue 7, Page 1707-1714, 1 October 2026.
The cancer risk in Marfan syndrome, an autosomal dominant connective tissue disorder, largely remains to be explored. In this population‐based matched cohort study of 1544 Swedish patients, the overall cancer risk in adults with Marfan syndrome showed no significant increase, except for the risk of endocrine tumours with a nearly threefold increase ...
Ida Nordgren, Anna Skarin Nordenvall, Alexandra Wachtmeister, Fulya Taylan, Yunxia Lu, Christina Norrby, Anna Lindstrand, Giedre Grigelioniene, Giorgio Tettamanti   +8 more
wiley   +1 more source

Enhanced prediction of postlaminar optic nerve invasion in retinoblastoma using high-resolution MRI: integrating qualitative imaging features, optic nerve measurements and tumor radiomics

This study aimed to develop a model for predicting postlaminar optic nerve invasion (PLONI) in retinoblastoma patients using MR imaging. The model was designed to incorporate recent advanced diagnostic techniques, including tumor radiomics, manual and ...
Moor, Maaike, Caan, Matthan W A, Sirin, Selma, Koob, Meriam, Galluzzi, Paolo, de Jong, Marcus C, Maeder, Philippe, Jansen, Robin W, Moll, Annette C, de Graaf, Pim, Cardoen, Liesbeth, Göricke, Sophia, van Elst, Sabien, Cysouw, Matthijs, de Bloeme, Christiaan M   +14 more
core   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Increasing Familial Retinoblastoma in High-Income Countries Despite Stable Overall Incidence, 2017-2024

To reassess retinoblastoma (RB) incidence in high-income countries (HICs) participating in the Global Retinoblastoma Study and evaluate temporal changes in the proportion of familial RB between 2017 and 2024. Multicenter repeated cross-sectional study.
Stathopoulos, Christina, Chawla, Bhavna, Al-Jadiry, Mazin Faisal, Dalvin, Lauren A, Bowman, Richard, Fabian, Ido Didi, Benvenuto, Franco, Cassoux, Nathalie, Sandri, Lara, Ademola-Popoola, Dupe S, Chaudhry, Shabana, Susanty, Anne, Essuman, Vera Adobea, Lustig-Barzelay, Yael, Staffieri, Sandra Elfride, Bansal, Rolika, Comsa, Codruta   +16 more
core   +1 more source

How we manage patients with retinoblastoma [PDF]

, 2018
When a child with retinoblastoma reports to our centre, a message is immediately passed on to a physician who treats ...
Vikas Khetan
core  

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Epidemiological and genetic considerations in retinoblastoma [PDF]

, 2018
Retinoblastoma is usually initiated by a random mutation of a gene in a retinal cell. It is important to try and recognise if the child has germline retinoblastoma, as this may affect both eyes of the child.
Sandeep S Sagoo, Fabian, ID, Ido Didi Fabian, Rosser, E, Sagoo, MS, Elisabeth Rosser   +5 more
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