Results 111 to 120 of about 3,600,316 (189)

Recent Trends in the Management of Retinoblastoma

, 2015
Retinoblastoma is the most common intraocular malignancy of childhood. Significant progress has been made in the past few years in the management of retinoblastoma. Thus, the patients’ survival and ocular salvage rates have shown marked improvement. The
Derda Özer, Ozer, Derda, Samuray Tuncer, Tuncer, Samuray   +3 more
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

How we manage patients with retinoblastoma [PDF]

, 2018
When a child with retinoblastoma reports to our centre, a message is immediately passed on to a physician who treats ...
Vikas Khetan
core  

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Productive or Transforming? How Epithelial Compartmentalization of HPV DNA and E6/E7 Transcripts Shapes Cervical Screening Assay Performance

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The human papillomavirus (HPV) life cycle is linked to epithelial cell differentiation, with viral genome amplification, E6/E7 transcription, and virion assembly spatially compartmentalized within the cervical epithelium. This organization is disrupted in transforming lesions.
Konstanze Schichl, John Doorbar
wiley   +1 more source

Global Retinoblastoma Presentation and Analysis by National Income Level.

, 2020
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late.
De Potter, Patrick, Global Retinoblastoma Study Group, Brichard, Bénédicte   +2 more
core   +1 more source

Menin controls the concentration of retinoblastoma protein.

, 2011
International audienceMenin, the protein encoded by the Multiple Endocrine Neoplasia type 1 gene, is involved in the cell cycle control through its participation in functional dynamics of chromatin and regulation of transcription.
Corset, Laetitia, Dina Ivo, Ivo, Dina, Laetitia Corset, Desbourdes, Laura, Patrick Gaudray, Gaudray, Patrick, Weber, Günther, Günther Weber, Laura Desbourdes   +9 more
core   +2 more sources

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Enhanced prediction of postlaminar optic nerve invasion in retinoblastoma using high-resolution MRI: integrating qualitative imaging features, optic nerve measurements and tumor radiomics

This study aimed to develop a model for predicting postlaminar optic nerve invasion (PLONI) in retinoblastoma patients using MR imaging. The model was designed to incorporate recent advanced diagnostic techniques, including tumor radiomics, manual and ...
Moor, Maaike, Caan, Matthan W A, Sirin, Selma, Koob, Meriam, Galluzzi, Paolo, de Jong, Marcus C, Maeder, Philippe, Jansen, Robin W, Moll, Annette C, de Graaf, Pim, Cardoen, Liesbeth, Göricke, Sophia, van Elst, Sabien, Cysouw, Matthijs, de Bloeme, Christiaan M, European Retinoblastoma Imaging Collaboration, Sirin, Selma; https://orcid.org/   +16 more
core   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, Volume 115, Issue 11, Page 2603-2615, November 2026.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source