Results 131 to 140 of about 3,403,478 (241)

Sclareol Inhibit Cell Growth and Induces Apoptosis via Activation of p53/p21 Signaling Pathways in Human Oral Squamous Cell Carcinoma Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The Schematic representation of the possible molecular mechanism of sclareol induces apoptosis through p53 and p21‐associated signaling in KB cells. ABSTRACT One of the most common prevalent forms of cancer in the world is oral squamous cell carcinoma (OSCC).
Anandhi Nallu, Suresh Kathiresan, Theerthu Azhamuthu, Hemavardhani Ramadoss, Nihal Ahamed Abulkalam Asath, Pugazhendhi Ravichandran, Rajeswari Vasu   +6 more
wiley   +1 more source

Recent Trends in the Management of Retinoblastoma

, 2015
Retinoblastoma is the most common intraocular malignancy of childhood. Significant progress has been made in the past few years in the management of retinoblastoma. Thus, the patients’ survival and ocular salvage rates have shown marked improvement. The
Derda Özer, Ozer, Derda, Samuray Tuncer, Tuncer, Samuray   +3 more
core   +1 more source

Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci. [PDF]

Life Sci Alliance, 2022
Wong KM, King DA, Schwartz EK, Herrera RE, Morrison AJ.   +4 more
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. [PDF]

Structure, 2022
Putta S, Alvarez L, Lüdtke S, Sehr P, Müller GA, Fernandez SM, Tripathi S, Lewis J, Gibson TJ, Chemes LB, Rubin SM.   +10 more
europepmc   +1 more source

Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand, Kristina Macova, Dominika Fricova   +2 more
wiley   +1 more source

Retinoblastoma protein: a central processing unit

Journal of Biosciences, 2009
The retinoblastoma protein (pRb) is one of the key cell-cycle regulating proteins and its inactivation leads to neoplastic transformation and carcinogenesis. This protein regulates critical G1 -to-S phase transition through interaction with the E2F family of cell-cycle transcription factors repressing transcription of genes required for this cell-cycle
openaire   +2 more sources

Translocation of nuclear chromatin distribution to the periphery reflects dephosphorylated threonine-821/826 of the retinoblastoma protein (pRb) in T24 cells treated with Bacillus Calmette-Guérin. [PDF]

Cytotechnology, 2023
Uehara T, Watanabe S, Yamaguchi S, Eguchi N, Sakamoto N, Oda Y, Arimura H, Kaku T, Ohishi Y, Mizuno S.   +9 more
europepmc   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

In silico identification of novel CDK4 inhibitors for retinoblastoma

Chemical Physics Impact
Retinoblastoma is a kind of cancer that mostly affects children's eyes, and this study intends to find drugs that can suppress the protein kinase cyclin-dependent kinase 4 (CDK4).
Mukesh kumar, Vikas Srivastava, Uma Devi, KhemRaj Nackwal, Mohammad Z. Ahmed, Prakash K. Shukla   +5 more
doaj   +1 more source