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To evaluate the effectiveness of baseline screening and follow-up with magnetic resonance imaging (MRI) for detecting trilateral retinoblastoma (TRb) and assessing the risk of TRb development. Prospective multicenter cohort study.
Casseri, T. +32 more
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Risk definition and management strategies in retinoblastoma: current perspectives
Fariba Ghassemi, Alireza Khodabande Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Tehran Province, Islamic Republic of Iran Abstract: This manuscript focuses on high-risk factors of metastatic disease in ...
Khodabande A, Ghassemi F
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Retinoma, also referred to as retinocytoma, is a benign manifestation of biallelic retinoblastoma gene (RB1) inactivation. Genetic or epigenetic loss of retinoblastoma protein in maturing cone precursors induces genomic instability which leads to ...
Panagiotis N. Toumasis +3 more
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Plant retinoblastoma-associated proteins
Filing Date: 1997-06-12 -- Priority Data: ES PCT/ES96/00130 (1996-06-13)The present invention is based on the isolation and characterization of a plant cell DNA sequence encoding for a retinoblastoma protein.
Sanz Burgos, Andrés +3 more
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Centromere Protein E as a Novel Biomarker and Potential Therapeutic Target for Retinoblastoma
Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database.
Xiaodong Sun, Shi Ke, Jingfa Zhang
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The Retinoblastoma Protein and Its Relatives
Seminars in Cancer Biology, 1995The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming proteins are structurally and ...
Peter Whyte, P Whyte
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The Family of Retinoblastoma Proteins
Critical Reviews in Eukaryotic Gene Expression, 2001Our understanding of how the retinoblastoma family members, pRB/p105, pRB2/p130, and pRBL1/p107, regulate cellular properties has progressed significantly. Mechanisms have been described regarding how these proteins utilize properties of additional factors, such as histone deacetylases, to negatively regulate transcription.
Stiegler P., Giordano A.
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Transcriptional Control by the Retinoblastoma Protein
Seminars in Cancer Biology, 1995The retinoblastoma gene product is an abundant nuclear protein whose 'pocket domain' mediates numerous protein-protein interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription.
Tony Kouzarides
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