Results 151 to 160 of about 3,600,316 (189)
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Corepressors and Retinoblastoma Protein Function
2001The retinoblastoma protein (Rb) is a ubiquitous transcriptional repressor and a negative regulator of the Gl-to-S phase transition in the eukaryotic cell cycle. Through this inhibitory activity, Rb plays a critical role in suppressing neoplastic transformation and is disrupted in most cancers, either by mutation of the Rb gene (Lee et al. 1988; Shew et
J W, Harbour, D C, Dean
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Transcriptional regulation by the retinoblastoma protein
Trends in Cell Biology, 1993The retinoblastoma protein (RB) plays a key role in the control of cell proliferation and mediates the terminal differentiation of certain cell types. Increasing evidence suggests that RB functions by contacting and modifying the behaviour of transcription factors.
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The retinoblastoma tumor suppressor protein
Current Opinion in Genetics & Development, 1995Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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Regulation of transcription by the retinoblastoma protein
Genes, Chromosomes and Cancer, 1993AbstractThe product of the retinoblastoma gene (RB1) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RB1 may exert its growth‐suppressing activity by regulating the transcription of a variety of growth‐related genes, including FOS, MYC, and TGFB1.
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Immunohistochemical Detection of the Retinoblastoma Protein
2018The retinoblastoma protein (pRB) plays a key role in proliferative control and genome stability. For these reasons its functions are considered to be tumor suppressive. Its functional status offers critical insight into proliferative control signaling in tissues and in developing malignancies.
Charles A, Ishak +3 more
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The Retinoblastoma Protein Pathway and the Restriction Point
Current Opinion in Cell Biology, 1996The emerging role of the retinoblastoma protein (pRb) as a major controller of the restriction point has been supported by recent discoveries, including pRb's ability to repress gene transcription by all three RNA polymerases, which suggests a link between DNA replication and cell growth.
Jiří Bártek +2 more
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Immunohistochemistry of apoptosis-related proteins in retinoblastoma
Pathology - Research and Practice, 2016Retinoblastoma is the most common intraocular malignant neoplasia during childhood and results from the partial or total inactivity of the retinoblastoma protein (pRb). In the absence of pRb, the E2F transcription factors increase the levels of cell cycle proteins as well as some pro-apoptotic proteins.
Renato José Mendonça Natalino +4 more
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Molecular dynamics simulations of retinoblastoma protein
Journal of Biomolecular Structure and Dynamics, 2012Tumor suppressor proteins play a crucial role in cell cycle regulation. Retinoblastoma protein (pRB) is one among them which regulates G1-S transition by binding with transcription factors. The activity of pRB is deregulated by cyclin dependent kinases-mediated hyper-phosphorylation and also due to cancer-derived mutations.
C, Ramakrishnan +3 more
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Involvement of Polyamines in Retinoblastoma Protein Phosphorylation
Biochemical and Biophysical Research Communications, 1998Hepatocyte growth factor (HGF) increased both levels of phosphorylated and non-phosphorylated forms of retinoblastoma protein (RB) in primary cultured rat hepatocytes. Combined treatment of HGF and a specific inhibitor of ornithine decarboxylase (ODC), alpha-difluoromethylornithine (DFMO), reduced the levels of hyper-phosphorylated and hypo ...
T, Omura +5 more
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The cell cycle and the retinoblastoma protein family
Cancer and Metastasis Reviews, 1994Tumor formation results from alterations in the control of normal cell proliferation. To further our understanding of the molecular mechanisms underlying the deregulation of cell proliferation much attention, over the past decade, has been focused on the function of proto-oncogenes. Cellular oncogenes are thought to be growth promoting.
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