Results 171 to 180 of about 50,772 (264)

Synergistic Interaction Between HPV‐16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Armando Chávez‐Ríos, Celina López‐Ruiz, Ian A. García‐Aguirre, Rodolfo Ocadiz‐Delgado, Francisco Garcia‐Sierra, Rogelio Hernández‐Pando, Solangy Lizcano‐Meneses, Patricio Gariglio   +7 more
wiley   +1 more source

Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression. [PDF]

Cancer Immunol Res
Tcyganov EN, Kwak T, Yang X, Poli ANR, Hart C, Bhuniya A, Cassel J, Kossenkov AV, Auslander N, Lu L, Sharma P, Cauti Mendoza MG, Zhigarev D, Cramer GM, Cadungog MG, Jean S, Chatterjee-Paer S, Weiner DB, Donthireddy L, Bristow B, Zhang R, Tyurin VA, Tyurina YY, Bayir H, Kagan VE, Salvino JM, Montaner LJ.   +26 more
europepmc   +1 more source

A masked initiation region in retinoblastoma protein regulates its proteasomal degradation. [PDF]

Nat Commun, 2020
Tomita T, Huibregtse JM, Matouschek A.
europepmc   +1 more source

Sublineage‐Specific A45S Polymorphism Alters the Biological Function of the Human Papillomavirus 11 E7 Protein

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT The E7 oncoprotein of human papillomavirus (HPV) plays a crucial role in viral pathogenesis and replication. Although it is generally highly conserved across HPV genotypes, naturally occurring E7 variants can display functional differences that may affect viral persistence, oncogenic potential, and host cellular responses.
Zsolt Barnabás Éles, Leila Rahmani, Eszter Gyöngyösi, Krisztina Szarka, István Rebenku, György Veress, Tamás Major, József Kónya, Anita Szalmás   +8 more
wiley   +1 more source

Role of Novel Target Molecules (β-Catenin and Retinoblastoma Protein) in the Spectrum of Inflammatory Bowel Disease. [PDF]

Cureus
Bharambe MV, Doshi PR, Lakhe RR, Kulkarni PS, Bharadwaj RP.   +4 more
europepmc   +1 more source

Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang, Hong Huang, Jin Lin, Yanan Niu, Jiaxin Chen, Jiaxuan Tang, Zhengyuan Hu, Peng Liu, Jun Qu   +8 more
wiley   +1 more source

Correction: Post-translational modifications on the retinoblastoma protein. [PDF]

J Biomed Sci
Zhou L, Ng DS, Yam JC, Chen LJ, Tham CC, Pang CP, Chu WK.   +6 more
europepmc   +1 more source

Role of Retinoblastoma Protein Family (Rb/p105 and Rb2/p130) Expression in the Histopathological Classification of Borderline Ovarian Tumors. [PDF]

Front Med (Lausanne), 2020
Masciullo V, Valdivieso P, Amadio G, Santoro A, Angelico G, Sgambato A, Boffo S, Giordano A, Scambia G, Zannoni GF.   +9 more
europepmc   +1 more source

Protein and gene expression analyses in bone marrow stem cells mediated restoration of myocardium after ischemic insult

, 2010
PhDMyocardial Infarction (MI) is caused by occlusion of the coronary artery following atheromatous plaque rupture, the subsequent ischemia in the myocardium leads to myocyte necrosis unless treated quickly. Bone marrow derived stem cell treatment is a
Lee, Kate L
core  

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source