Results 191 to 200 of about 50,772 (264)

Single‐Cell RNA‐Seq Combined With Bulk RNA‐Seq Revealed the Involvement of Pancreatic Cancer Tissue‐Resident Macrophages in Tumour Progression and the Immunotherapy Response

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer remains a highly lethal malignancy with limited therapeutic efficacy and untapped immunotherapeutic potential, largely constrained by immune cell heterogeneity in the tumour microenvironment. Tumour‐associated macrophages (TAMs), especially tissue‐resident macrophages (TRMs), exert complex regulatory roles in tumour ...
Bin Wu, Chundong Hu, Fengchun Lu
wiley   +1 more source

DEFECTIVE HUMAN RETINOBLASTOMA PROTEIN IDENTIFIED BY LACK OF INTERACTION WITH THE E1A ONCOPROTEIN

, 1994
Inactivating mutations of the retinoblastoma susceptibility gene (Rb) are involved in the pathogenesis of hereditary and sporadic retinoblastoma. Alterations in the Rb gene have also been found in several other human tumors occurring with epidemiological
M. G. Paggi, T. Bruno, M. Fanciulli, F. Martelli, SCIACCHITANO, Salvatore, M. Varmi, A. Floridi, C. M. Carapella, A. Felsani   +8 more
core  

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Diversification of Retinoblastoma Protein Function Associated with Cis and Trans Adaptations. [PDF]

Mol Biol Evol, 2019
Mouawad R, Prasad J, Thorley D, Himadewi P, Kadiyala D, Wilson N, Kapranov P, Arnosti DN.   +7 more
europepmc   +1 more source

Intravesical Delivery of P21 mRNA–Loaded Lipid Nanoparticles as a Tumor Suppressor Replacement Therapy for Bladder Cancer

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intravesical delivery of p21 mRNA‐loaded lipid nanoparticles (p21‐LNP) restores the tumor suppressor p21 in bladder cancer. Localized p21 expression directly induces cell cycle arrest, DNA damage and apoptosis, and ultimately inhibits orthotopic tumor growth with minimal systemic distribution and favorable safety.
Jie Zeng, Ziyi Cao, Chenghe Wang, Yingjie Xu   +3 more
wiley   +1 more source

Retinoblastoma-Associated Protein [PDF]

, 2020
openaire   +1 more source

Potential Roles of the Retinoblastoma Protein in Regulating Genome Editing. [PDF]

Front Cell Dev Biol, 2018
Jiang Y, Chu WK.
europepmc   +1 more source

NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein. [PDF]

Mol Cell Biol, 2020
Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, Tamura N, Hatanaka A, Hirose S, Katayama H, Tani M, Kubo Y, Hamazaki J, Hamakubo T, Watanabe A, Murata S, Kobayashi A.   +16 more
europepmc   +1 more source

Retinoblastoma protein (Rb) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Immunohistochemical Detection of Retinoblastoma Protein Phosphorylation in Human Tumor Samples. [PDF]

Methods Mol Biol, 2018
Pérez-Morales J, Núñez-Marrero A, Santiago-Cardona PG.   +2 more
europepmc   +1 more source