Results 191 to 200 of about 3,403,478 (241)

Transcriptional inhibition by the retinoblastoma protein

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphorylated form is able to interact
Fattaey, A, Helin, K, Harlow, E
openaire   +3 more sources

Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma [PDF]

Modern Pathology, 2004
Mutation, absence or abnormal functioning of retinoblastoma protein are fundamental elements of uncontrolled growth in human cancer. In this study, we analyze the expression of retinoblastoma protein and phosphorylated retinoblastoma protein in ...
Alexander Roesch, Peter Johannes Wild, Stefanie Meyer   +2 more
exaly   +2 more sources

Transcriptional control by the retinoblastoma protein

Seminars in Cancer Biology, 1995
The retinoblastoma gene product is an abundant nuclear protein whose 'pocket domain' mediates numerous protein-protein interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription.
Tony Kouzarides
exaly   +3 more sources

Retinoblastoma protein partners

2001
Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent mutation of the Rb gene, and the functional inactivation of pRb in tumor cells, have spurred interest in the mechanism of pRb action.
E J, Morris, N J, Dyson
openaire   +2 more sources

The role of retinoblastoma protein in apoptosis

Apoptosis, 1999
The retinoblastoma gene and its protein product (Rb) have been studied intensively for their role in development, oncogenesis, cell growth, differentiation and cell cycle regulation. In addition, Rb appears to be a key factor in protecting cells from apoptosis.
G, Fan, C J, Steer
openaire   +2 more sources

Functions of the retinoblastoma protein

BioEssays, 1999
The retinoblastoma protein (pRB) can both positively and negatively regulate transcription. The former correlates with its ability to promote differentiation and the latter with its ability to regulate entry into S-phase. pRB negatively regulates transcription by forming complexes with members of the E2F transcription factor family.
openaire   +2 more sources

Retinoblastoma protein meets chromatin

Trends in Biochemical Sciences, 1999
The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure.
A, Brehm, T, Kouzarides
openaire   +2 more sources

Deciphering the retinoblastoma protein phosphorylation code [PDF]

Trends in Biochemical Sciences, 2013
Multisite phosphorylation modulates the function of regulatory proteins with complex signaling properties and outputs. The retinoblastoma tumor suppressor protein (Rb) is inactivated by cyclin-dependent kinase (Cdk) phosphorylation in normal and cancer cell cycles, so understanding the molecular mechanisms and effects of Rb phosphorylation is ...
Seth Rubin
exaly   +3 more sources

Retinoblastoma protein in microphthalmic mice

Experimental and Toxicologic Pathology, 2000
A microphthalmic strain of mice was used to study immunoresponse of the retinoblastoma protein. Comparing wild-type, heterozygote and homozygote microphthalmic eyes, we found an increasing labelling of phosphorylated retinoblastoma protein (pRb) in the retinal pigment epithelium.
J, Richter, E, Brylla, C, Lenk, J, Ernstberger, H, Hilbig   +4 more
openaire   +2 more sources

Retinoblastoma protein and the cell cycle

Current Opinion in Genetics & Development, 1993
Deregulation of the cell cycle may contribute one of the primary mechanisms through which cancer arises. Eukaryotic cell division has been found to be a strictly controlled process, involving response to both positive and negative external signals and assessment of the cell's internal state.
R E, Hollingsworth, C E, Hensey, W H, Lee   +2 more
openaire   +2 more sources