Results 201 to 210 of about 3,403,478 (241)

The retinoblastoma protein as a transcriptional repressor

Trends in Cell Biology, 1993
The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that pRB negatively regulates some aspect of normal cell growth.
Helin, K, Ed, H
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Corepressors and Retinoblastoma Protein Function

2001
The retinoblastoma protein (Rb) is a ubiquitous transcriptional repressor and a negative regulator of the Gl-to-S phase transition in the eukaryotic cell cycle. Through this inhibitory activity, Rb plays a critical role in suppressing neoplastic transformation and is disrupted in most cancers, either by mutation of the Rb gene (Lee et al. 1988; Shew et
J W, Harbour, D C, Dean
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Transcriptional regulation by the retinoblastoma protein

Trends in Cell Biology, 1993
The retinoblastoma protein (RB) plays a key role in the control of cell proliferation and mediates the terminal differentiation of certain cell types. Increasing evidence suggests that RB functions by contacting and modifying the behaviour of transcription factors.
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The retinoblastoma tumor suppressor protein

Current Opinion in Genetics & Development, 1995
Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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Regulation of transcription by the retinoblastoma protein

Genes, Chromosomes and Cancer, 1993
AbstractThe product of the retinoblastoma gene (RB1) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RB1 may exert its growth‐suppressing activity by regulating the transcription of a variety of growth‐related genes, including FOS, MYC, and TGFB1.
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Immunohistochemical Detection of the Retinoblastoma Protein

2018
The retinoblastoma protein (pRB) plays a key role in proliferative control and genome stability. For these reasons its functions are considered to be tumor suppressive. Its functional status offers critical insight into proliferative control signaling in tissues and in developing malignancies.
Charles A, Ishak, Matthew J, Cecchini, Christopher J, Howlett, Frederick A, Dick   +3 more
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Immunohistochemistry of apoptosis-related proteins in retinoblastoma

Pathology - Research and Practice, 2016
Retinoblastoma is the most common intraocular malignant neoplasia during childhood and results from the partial or total inactivity of the retinoblastoma protein (pRb). In the absence of pRb, the E2F transcription factors increase the levels of cell cycle proteins as well as some pro-apoptotic proteins.
Renato José Mendonça Natalino, Célia Beatriz Gianotti Antoneli, Karina de Cássia Braga Ribeiro, Antônio Hugo José Fróes Marques Campos, Fernando Augusto Soares   +4 more
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Molecular dynamics simulations of retinoblastoma protein

Journal of Biomolecular Structure and Dynamics, 2012
Tumor suppressor proteins play a crucial role in cell cycle regulation. Retinoblastoma protein (pRB) is one among them which regulates G1-S transition by binding with transcription factors. The activity of pRB is deregulated by cyclin dependent kinases-mediated hyper-phosphorylation and also due to cancer-derived mutations.
C, Ramakrishnan, V, Subramanian, K, Balamurugan, D, Velmurugan   +3 more
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Involvement of Polyamines in Retinoblastoma Protein Phosphorylation

Biochemical and Biophysical Research Communications, 1998
Hepatocyte growth factor (HGF) increased both levels of phosphorylated and non-phosphorylated forms of retinoblastoma protein (RB) in primary cultured rat hepatocytes. Combined treatment of HGF and a specific inhibitor of ornithine decarboxylase (ODC), alpha-difluoromethylornithine (DFMO), reduced the levels of hyper-phosphorylated and hypo ...
T, Omura, Y, Yano, T, Hasuma, H, Kinoshita, I, Matsui-Yuasa, S, Otani   +5 more
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The retinoblastoma protein pathway and the restriction point

Current Opinion in Cell Biology, 1996
The emerging role of the retinoblastoma protein (pRb) as a major controller of the restriction point has been supported by recent discoveries, including pRb's ability to repress gene transcription by all three RNA polymerases, which suggests a link between DNA replication and cell growth.
J, Bartek, J, Bartkova, J, Lukas
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