Results 161 to 170 of about 50,772 (264)

Characteristics and Outcomes of Patients With Dedifferentiated Liposarcoma in a US Community Setting

Cancer Medicine, Volume 15, Issue 6, June 2026.
US community oncology patients with dedifferentiated liposarcoma have heterogeneous profiles, treatments, and outcomes. The poor survival rates in this population suggest an unmet need for better therapeutics. ABSTRACT Introduction Clinical characteristics and outcomes of patients treated for dedifferentiated liposarcoma (DDLPS) at community oncology ...
James E. Butrynski, Bal Nepal, Chenxiao Hu, Jinhong Guo, Jennifer Han, Lisa Herms, Alyssa B. Klein, Stephen Stanhope, Elizabeth L. Stanley, Karen Todoroff, Paul Conkling   +10 more
wiley   +1 more source

Poly ADP Ribose Polymerase Inhibitor Olaparib Targeting Microhomology End Joining in Retinoblastoma Protein Defective Cancer: Analysis of the Retinoblastoma Cell-Killing Effects by Olaparib after Inducing Double-Strand Breaks. [PDF]

Int J Mol Sci, 2021
Jiang Y, Yam JC, Chu WK.
europepmc   +1 more source

An Atypical Presentation, Diagnostic Challenges, and Treatment Response of a Malignant Small Round Cell Tumor in the Lumbo‐Inguinal Region of an Infant

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Malignant small round cell tumors are a heterogeneous group of aggressive neoplasms characterized by small, round cell morphology. The undifferentiated cells in these tumors exhibit a high nuclear‐cytoplasmic ratio, and definitive histologic diagnosis via light microscopy can be extremely challenging. Diagnostic accuracy significantly improves
George Evele, Kouya Francine, Ngock George, Richard Bardin   +3 more
wiley   +1 more source

Roles of plant retinoblastoma protein: cell cycle and beyond. [PDF]

EMBO J, 2020
Desvoyes B, Gutierrez C.
europepmc   +1 more source

Methodological Insights Into T‐Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
PMA/ionomycin and CD3/CD28 stimulation induce fundamentally distinct signaling programs in primary human T cells. While CD3/CD28 stimulation activates both ERK and IL‐2/STAT5 signaling pathways, PMA/ionomycin induces predominantly ERK‐dependent proliferation despite robust IL‐2 production and CD25 upregulation.
Nekruz Abdulhaqov, Lady Tatiana Albarracin Melo, Ines Meinert, Stephan Fricke, Luca Simeoni   +4 more
wiley   +1 more source

TBP-1 (TAT BINDING PROTEIN-1) IN THE CONTROL OF CELL PROLIFERATION: FUNCTIONAL RELATIONSHIP WITH THE AKT/PKB SIGNALING PATHWAY

, 2011
TBP-1/Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription.
Festa, Luisa
core  

Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Fatemeh Beygnejad, Narges Eslami, Kaveh Gharaei Nejad, Atefeh Zamani Kermanshahi, Hossein Bannazadeh Baghi   +4 more
wiley   +1 more source

Retinoblastoma protein expression and its predictors in triple-negative breast cancer. [PDF]

NPJ Breast Cancer, 2020
Patel JM, Goss A, Garber JE, Torous V, Richardson ET, Haviland MJ, Hacker MR, Freeman GJ, Nalven T, Alexander B, Lee L, Collins LC, Schnitt SJ, Tung N.   +13 more
europepmc   +1 more source

Integrated Molecular Docking and Gene Expression Analyses Suggest a Potential Interaction Between Diphtheria Toxin and Bcl‐2 in HT‐29 Colorectal Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This study explores the interaction between Diphtheria Toxin (DT) and Bcl‐2 in HT‐29 cells. Integrating molecular docking with gene expression analysis, we demonstrate DT's high‐affinity binding to Bcl‐2 and a significant downregulation of BCL2 mRNA. These findings suggest that DT modulates anti‐apoptotic pathways, influencing colorectal cancer cell ...
Elif Ercan, Tugba Yalcinkaya, Belkis Levent, Ahmet Carhan   +3 more
wiley   +1 more source

Growth hormone-secreting adenoma with lack of retinoblastoma protein expression. [PDF]

JCEM Case Rep
Salvatori R, Gallia GL, Lucas CG.
europepmc   +1 more source