Results 141 to 150 of about 3,600,316 (189)

Retinoblastoma proteins in plants

Plant Molecular Biology, 1999
The retinoblastoma protein Rb is part of a conserved pathway that controls the activation of cell division in animals. Rb represses cell cycle transcription factors of the E2F family, and thereby prevents uncontrolled cell proliferation. Rb itself is inactivated when phosphorylated by cyclin-dependent kinases, and the D-type cyclin kinases are ...
S M, de Jager, J A, Murray
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Transcriptional inhibition by the retinoblastoma protein

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphorylated form is able to interact
Fattaey, A, Helin, K, Harlow, E
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Retinoblastoma protein partners

2001
Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent mutation of the Rb gene, and the functional inactivation of pRb in tumor cells, have spurred interest in the mechanism of pRb action.
E J, Morris, N J, Dyson
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Deciphering the Retinoblastoma Protein Phosphorylation Code [PDF]

Trends in Biochemical Sciences, 2013
Multisite phosphorylation modulates the function of regulatory proteins with complex signaling properties and outputs. The retinoblastoma tumor suppressor protein (Rb) is inactivated by cyclin-dependent kinase (Cdk) phosphorylation in normal and cancer cell cycles, so understanding the molecular mechanisms and effects of Rb phosphorylation is ...
Seth M Rubin
exaly   +3 more sources

The role of retinoblastoma protein in apoptosis

Apoptosis, 1999
The retinoblastoma gene and its protein product (Rb) have been studied intensively for their role in development, oncogenesis, cell growth, differentiation and cell cycle regulation. In addition, Rb appears to be a key factor in protecting cells from apoptosis.
G, Fan, C J, Steer
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Functions of the retinoblastoma protein

BioEssays, 1999
The retinoblastoma protein (pRB) can both positively and negatively regulate transcription. The former correlates with its ability to promote differentiation and the latter with its ability to regulate entry into S-phase. pRB negatively regulates transcription by forming complexes with members of the E2F transcription factor family.
openaire   +2 more sources

Retinoblastoma protein meets chromatin

Trends in Biochemical Sciences, 1999
The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure.
A, Brehm, T, Kouzarides
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Retinoblastoma protein in microphthalmic mice

Experimental and Toxicologic Pathology, 2000
A microphthalmic strain of mice was used to study immunoresponse of the retinoblastoma protein. Comparing wild-type, heterozygote and homozygote microphthalmic eyes, we found an increasing labelling of phosphorylated retinoblastoma protein (pRb) in the retinal pigment epithelium.
J, Richter, E, Brylla, C, Lenk, J, Ernstberger, H, Hilbig   +4 more
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Retinoblastoma protein and the cell cycle

Current Opinion in Genetics & Development, 1993
Deregulation of the cell cycle may contribute one of the primary mechanisms through which cancer arises. Eukaryotic cell division has been found to be a strictly controlled process, involving response to both positive and negative external signals and assessment of the cell's internal state.
R E, Hollingsworth, C E, Hensey, W H, Lee   +2 more
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The retinoblastoma protein as a transcriptional repressor

Trends in Cell Biology, 1993
The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that pRB negatively regulates some aspect of normal cell growth.
Helin, K, Ed, H
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