Results 141 to 150 of about 50,772 (264)
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
In silico identification of novel CDK4 inhibitors for retinoblastoma
Chemical Physics ImpactRetinoblastoma is a kind of cancer that mostly affects children's eyes, and this study intends to find drugs that can suppress the protein kinase cyclin-dependent kinase 4 (CDK4).
Mukesh kumar +5 more
doaj +1 more source
TTC39B destabilizes retinoblastoma protein promoting hepatic lipogenesis in a sex-specific fashion. [PDF]
J Hepatol, 2022 Hsieh J +8 more
europepmc +1 more source
The retinoblastoma protein—from bench to bedside
European Journal of Cell Biology, 2005 The retinoblastoma tumour suppressor protein (Rb) has come a long way since its initial discovery in 1986. Encoded by the first candidate tumour suppressor gene it has emerged a versatile and context-dependent modulator of cell behaviour. Its activity is managed by signalling networks sensing intra- and extracellular cues.
openaire +2 more sources
Medicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He +2 more
wiley +1 more source
Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells. [PDF]
Biomolecules, 2022 Schomann T +6 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin +4 more
wiley +1 more source
Decreased sensitivity of cyclin-dependent kinase 4/6 inhibitors, palbociclib and abemaciclib to canine lymphoma cells with high p16 protein expression and low retinoblastoma protein phosphorylation. [PDF]
J Vet Med Sci, 2023 Maylina L +5 more
europepmc +1 more source
Plant retinoblastoma-associated proteins
, 1997 Filing Date: 1997-06-12 -- Priority Data: ES PCT/ES96/00130 (1996-06-13)The present invention is based on the isolation and characterization of a plant cell DNA sequence encoding for a retinoblastoma protein.
Sanz Burgos, Andrés +3 more
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