Results 121 to 130 of about 3,600,316 (189)

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 994-999, November 2026.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

Cutaneous Leiomyosarcoma of the Skin: An Updated Review of Epidemiology, Pathogenesis, and Management

International Journal of Dermatology, Volume 65, Issue 11, Page 2232-2238, November 2026.
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi, Natalie Garcia, Malak Husseinali, Nabeeha Engineer, Ikue Shimizu   +4 more
wiley   +1 more source

The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

, 2016
Changes in histone methylation status regulate chromatin structure and DNA-dependent processes such as transcription. Recent studies indicate that, analogous to other histone modifications, histone methylation is reversible.

core   +1 more source

Pengaruh Pemberian Ekstrak Jintan Hitam (Nigella Sativa) terhadap Apoptosis pada Kultur Sel Retinoblastoma Melalui Ekspresi Protein E2F1 [PDF]

, 2018
Retinoblastoma merupakan kanker intraokular tersering yang terjadi pada anak. Retinoblastoma merupakan tumor neuroblastik yang diakibatkan oleh mutasi gen retinoblastoma (gen RB1) yang menyebabkan mutasi protein retinoblastoma (pRB), sehingga tidak ...
dr. Lely Retno Wulandari, Sp.M(K)., Aida, dr. Hariwati Moehariadi, Sp.M(K) ., dr. Hidayat Sujuti, Sp.M, Ph.D.   +3 more
core  

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study [PDF]

MYCN-amplified RB1 wild-type (MYCN amp RB1 +/+) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed
Robin W. Jansen, Saugata Sen, Sophia Göricke, Paolo Galluzzi, Pim de Graaf, Matthijs Cysouw, Liesbeth Cardoen, Hervé J. Brisse, Kim E. Nichols, Alison H. Skalet, H. Culver Boldt, Audra K. Miller, Ronald Boellaard, Josephine C. Dorsman, Hans Grossniklaus, Rachel C. Brennan, Mériam Koob, Annette C. Moll, European Retinoblastoma Imaging Collaboration, Charlotte J. Dommering, Aparna Ramasubramanian, Philippe Maeder, Sabien van Elst, Jaime Lyn Jessen, Ogul E. Uner, Marcus C. de Jong, Christiaan M. de Bloeme, Selma Sirin, G. Baker Hubbard, Brennan, Rachel C., de Jong, Marcus C., Dommering, Charlotte J; https://orcid.org/, Moll, Annette C; https://orcid.org/, de Bloeme , Christiaan M., Sen, Saugata; https://orcid.org/, Dorsman, Josephine C., Dorsman, J.C., Hubbard, G Baker; https://orcid.org/, Moll, A.C., Sirin, Selma; https://orcid.org/, Brisse, H.J., Hubbard, G. Baker, Miller, Audra K., Skalet, Alison H, Dommering, C.J., Nichols, Kim E., Cysouw, Matthijs, Skalet, A.H., Ramasubramanian, A., Nichols, Kim E; https://orcid.org/, Moll, Annette C., Ramasubramanian, Aparna, Sen, Saugata, van Elst, S., van Elst, Sabien, de Jong, Marcus C; https://orcid.org/, Cysouw, M., Grossniklaus, H., Jansen, Robin W., Galluzzi, Paolo, Koob, M., Boellaard, Ronald; https://orcid.org/, Boellaard, R., Maeder, Philippe; https://orcid.org/, de Bloeme, Christiaan M; https://orcid.org/, Uner, Ogul E; https://orcid.org/, Sirin, S., de Bloeme, C.M., Jessen, Jaime Lyn, de Jong, M.C., Göricke, S., Uner, Ogul E., Koob, Mériam, Sirin, Selma, Brisse, Hervé J; https://orcid.org/, Uner, O.E., Jansen, Robin W; https://orcid.org/, de Graaf, Pim; https://orcid.org/, Cardoen, Liesbeth, Cardoen, L., Nichols, K.E., Galluzzi, P., Grossniklaus, Hans, Jansen, R.W., Galluzzi, Paolo; https://orcid.org/, Skalet, Alison H., Brennan, Rachel C; https://orcid.org/, Boellaard, Ronald, Boldt, H.C., Miller, A.K., Maeder, Philippe, Brisse, Hervé J., Sen, S., Boldt, H Culver; https://orcid.org/, de Graaf, P., Dorsman, Josephine C, de Graaf, Pim, Jessen, J.L., Cardoen, Liesbeth; https://orcid.org/, Miller, Audra K; https://orcid.org/, Dommering, Charlotte J., van Elst, Sabien; https://orcid.org/, Brennan, R.C., Maeder, P., Boldt, H. Culver, Göricke, Sophia, Hubbard, G.B.   +106 more
core   +1 more source

Retinoblastoma: Clinical and Molecular Perspectives

, 2016
Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers ...
Harbour, J. William, J. William Harbour
core   +1 more source

Retinoblastoma protein: a central processing unit

Journal of Biosciences, 2009
The retinoblastoma protein (pRb) is one of the key cell-cycle regulating proteins and its inactivation leads to neoplastic transformation and carcinogenesis. This protein regulates critical G1 -to-S phase transition through interaction with the E2F family of cell-cycle transcription factors repressing transcription of genes required for this cell-cycle
openaire   +2 more sources

A gender-specific retinoblastoma-related protein in Volvox carteri implies a role for the retinoblastoma protein family in sexual development

, 2008
Kianianmomeni A, Nematollahi G, Hallmann A. A gender-specific retinoblastoma-related protein in Volvox carteri implies a role for the retinoblastoma protein family in sexual development. Plant Cell.
Kianianmomeni, Arash, Hallmann, Armin ; https://orcid.org/, Nematollahi, G.   +2 more
core   +1 more source

In silico identification of novel CDK4 inhibitors for retinoblastoma

Chemical Physics Impact
Retinoblastoma is a kind of cancer that mostly affects children's eyes, and this study intends to find drugs that can suppress the protein kinase cyclin-dependent kinase 4 (CDK4).
Mukesh kumar, Vikas Srivastava, Uma Devi, KhemRaj Nackwal, Mohammad Z. Ahmed, Prakash K. Shukla   +5 more
doaj   +1 more source

Molecular basis of low-penetrance retinoblastoma

, 2001
Retinoblastoma is a malignant tumor of the retina that occurs primarily in young children as a result of mutations in the retinoblastoma gene (RB), the first tumor suppressor gene to be identified.
Harbour, J W
core   +1 more source