Results 101 to 110 of about 3,600,316 (189)

A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Communications Biology
Retinoblastoma are childhood eye tumors arising from retinal precursor cells. Two distinct retinoblastoma subtypes with different clinical behavior have been described based on gene expression and methylation profiling.
Tatsiana Ryl, Elena Afanasyeva, Till Hartmann, Melanie Schwermer, Markus Schneider, Christopher Schröder, Maren Wagemanns, Arthur Bister, Deniz Kanber, Laura Steenpass, Kathrin Schramm, Barbara Jones, David T. W. Jones, Eva Biewald, Kathy Astrahantseff, Helmut Hanenberg, Sven Rahmann, Dietmar R. Lohmann, Alexander Schramm, Petra Ketteler   +19 more
doaj   +1 more source

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

International Journal of Cancer, Volume 159, Issue 12, Page 3029-3037, 15 December 2026.
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Marianne Gardar Stærk, Birgitte Grønkær Toft, Christina Stilling, Johanna Elversang, Sanne Kjær‐Frifeldt, Sonja Höhle Hjulskov, Sanja Stifter‐Vretenar, Marie Aarslev Schou, Mikael Aagaard, Peter Meidahl Petersen, Jakob Kristian Jakobsen, Christian Munk, Susanne Krüger Kjær   +12 more
wiley   +1 more source

Systems‐level phosphoproteomics reveals calcium/calmodulin‐dependent protein kinase kinase 2‐driven kinase signaling underlying malignant phenotypes in gastric cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
CAMKK2 inhibition induces extensive phosphoproteomic remodeling associated with cell cycle regulation, RNA processing, and kinase signaling networks in gastric cancer. Integrated systems‐level analyses identified dysregulated CDK, SRPK, MAPK, and AKT signaling pathways underlying malignant phenotypes and highlighted CAMKK2 as a potential therapeutic ...
Mohd. Altaf Najar, T. S. Keshava Prasad, Prashant Kumar Modi   +2 more
wiley   +1 more source

Retinoblastoma in transgenic mice [PDF]

, 1990
Retinoblastoma, a malignancy of the eye occurring in young children, has been widely studied as a model for genetic predisposition to cancer. This disease is caused by mutations in both alleles of an anti-oncogene (the retinoblastoma gene, Rb) that ...
Bernards, R.A., Windle, J.J., Disteche, Ch.M., O'Brien, J.M., Albert, D.M., Mellon, P.L., Marcus, D.M.   +6 more
core  

Correction: A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer

, 2014
Correction: A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell ...
PLOS Biology The Staff (642654)
core   +1 more source

Expression of FasL in Proliferation of Retinoblastoma Cells: A Mechanism Fas Counterattack

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
Purpose: The aim of this study were to determine the association of increasing of FasL with increasing proliferation of retinoblastoma cells. Materials and Methods: The protein expression was analyzed in 30 retinoblastoma samples from paraffin block ...
Hendrian Dwikoloso Soebagjo, Hidayat Sujuti, Hasan Machfoed, Sutiman Bambang Soemitro   +3 more
doaj  

Atypical intravitreal growth of retinoblastoma with a multi-branching configuration

American Journal of Ophthalmology Case Reports, 2017
Purpose: To report the clinical and histopathological findings of atypical intravitreal growth of a retinoblastoma with a multi-branching configuration.
Sachiko Nishina, Satoshi Katagiri, Atsuko Nakazawa, Chikako Kiyotani, Tadashi Yokoi, Noriyuki Azuma   +5 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

IL-18 suppresses retinoblastoma growth while concomitantly inducing an inflammation-/stress-associated and immune-remodeling response

Cancer Cell International
Retinoblastoma is the most common intraocular malignancy in childhood and remains associated with substantial treatment related morbidity. Interleukin 18 (IL-18) is an immunomodulatory cytokine with context dependent roles in cancer, yet its functional ...
Zide Chen, Wanqian Luo, Dongyang Wei, Qi Wang, Qing Gou, Jiawei Cao, Qicong Mai, Xiumei Chen, Xiaowen Cai, Xiaoming Chen, Jing Zhang   +10 more
doaj   +1 more source

Association Between BMI and the Efficacy and Safety of CDK4/6 Inhibitors in HR+/HER2− Advanced Breast Cancer: A Multicenter Retrospective Propensity Score Matched Cohort Study (CAMELIA)

MedComm – Oncology, Volume 5, Issue 4, December 2026.
This multicenter real‐world study showed that higher BMI (≥ 25 kg/m2) was independently associated with improved PFS in patients with HR+/HER2− advanced breast cancer receiving CDK4/6 inhibitors. Safety outcomes were comparable between BMI groups, and the findings were consistent across alternative BMI thresholds, suggesting the potential prognostic ...
Min Tian, Yijia Hua, Qian Liu, Nan Jin, Xinyu Wu, Kun Wang, Min Yan, Tao Sun, Chunfang Hao, Yanxia Zhao, Wei Li, Xiang Huang, Yongmei Yin   +12 more
wiley   +1 more source