Results 21 to 30 of about 50,847 (238)
eLife, 2013 Cachexia, a condition that kills about one-fifth of cancer patients, may be linked to Rb—a protein that is already linked to various cancers—moving from the cell nucleus to the cytoplasm.
Giulio Cossu +2 more
doaj +1 more source
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
core +1 more source
Molecular Biology of Retinoblastoma [PDF]
The molecular biology of retinoblastoma has led to a revolution in our understanding of cancer biology. This chapter reviews the discovery and subsequent elucidation of RB1, the first tumor suppressor gene, and its protein product, Rb.
Walter, Scott D, Harbour, J. William
core +3 more sources
Expression of MMP-14 and CD44 associated with proliferation of retinoblastoma cells
Medicine Science, 2019 Retinoblastoma is a the most common primary intraocular malignant tumor in childhood. The eexpressions of CD44 and MMP-14 and Their role in proliferation and migration cells appear crucial for retinoblastoma invasion.
Hendrian D. Soebagjo +4 more
doaj +1 more source
Acta Neuropathologica Communications, 2021 Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1. Rare cases of sellar-suprasellar region retinoblastoma without evidence of ocular or pineal tumors have been ...
Kathleen M. Schieffer +30 more
doaj +1 more source
BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]
, 2010 In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Adriano Ceccarelli +9 more
core +1 more source
Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension [PDF]
, 2016 Gene discovery in animal models may lead to the revelation of therapeutic targets for essential hypertension as well as mechanistic insights into blood pressure (BP) regulation.
Annie Ménard (2606101) +2 more
core +1 more source
Haematologica, 2015 Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts are embryonic lethal due to heart defects, and this precludes the investigation of their overlapping roles in definitive hematopoiesis.
Senthil Raja Jayapal +7 more
doaj +1 more source
Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. [PDF]
PLoS ONE, 2013 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed that AICAR-induced AMPK activation
Sofia Theodoropoulou +6 more
doaj +1 more source
RBBP7 (retinoblastoma binding protein 7) [PDF]
, 2010 Review on RBBP7 (retinoblastoma binding protein 7), with data on DNA, on the protein encoded, and where the gene is ...
Sinha, N, R Tamuli, Tamuli, R, N Sinha
core +1 more source