Results 21 to 30 of about 50,772 (264)

Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma

Acta Neuropathologica Communications, 2021
Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1. Rare cases of sellar-suprasellar region retinoblastoma without evidence of ocular or pineal tumors have been ...
Kathleen M. Schieffer, Alexander Z. Feldman, Esko A. Kautto, Sean McGrath, Anthony R. Miller, Maria Elena Hernandez-Gonzalez, Stephanie LaHaye, Katherine E. Miller, Daniel C. Koboldt, Patrick Brennan, Benjamin Kelly, Amy Wetzel, Vibhuti Agarwal, Margaret Shatara, Suzanne Conley, Diana P. Rodriguez, Rolla Abu-Arja, Ala Shaikhkhalil, Matija Snuderl, Brent A. Orr, Jonathan L. Finlay, Diana S. Osorio, Annie I. Drapeau, Jeffrey R. Leonard, Christopher R. Pierson, Peter White, Vincent Magrini, Elaine R. Mardis, Richard K. Wilson, Catherine E. Cottrell, Daniel R. Boué   +30 more
doaj   +1 more source

BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]

, 2010
In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Adriano Ceccarelli, Ceccarelli Adriano, Ceccarelli, Adriano, Harry K MacWilliams, MacWilliams Harry K., MacWilliams, Harry K., Conte Daniele, Daniele Conte, Harry K. MacWilliams, Conte, Daniele   +9 more
core   +1 more source

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress

Haematologica, 2015
Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts are embryonic lethal due to heart defects, and this precludes the investigation of their overlapping roles in definitive hematopoiesis.
Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, Vinay Tergaonkar, Motomi Osato, Philipp Kaldis   +7 more
doaj   +1 more source

Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. [PDF]

PLoS ONE, 2013
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR), an analog of AMP is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. Recently, we showed that AICAR-induced AMPK activation
Sofia Theodoropoulou, Katarzyna Brodowska, Maki Kayama, Yuki Morizane, Joan W Miller, Evangelos S Gragoudas, Demetrios G Vavvas   +6 more
doaj   +1 more source

RBBP7 (retinoblastoma binding protein 7) [PDF]

, 2010
Review on RBBP7 (retinoblastoma binding protein 7), with data on DNA, on the protein encoded, and where the gene is ...
Sinha, N, R Tamuli, Tamuli, R, N Sinha
core   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Gutierrez-Marcos, José F., Liliana M Costa, Costa Liliana M, Costa, Liliana M., José F Gutierrez-Marcos, Gutierrez-Marcos José F   +5 more
core   +1 more source

RBBP8 (retinoblastoma binding protein 8) [PDF]

, 2009
Review on RBBP8 (retinoblastoma binding protein 8), with data on DNA, on the protein encoded, and where the gene is ...
Chinnadurai, G, Subramanian, T, Vijayalingam, S   +2 more
core   +1 more source

ASSOCIATION OF RS2069502 CYCLIN-DEPENDENT KINASE 4 GENE WITH BREAST CANCER [PDF]

Euromediterranean Biomedical Journal, 2020
The goal of this project was to evaluate the association of candidate genetic variant rs2069502 of the CDK4 gene with breast cancer and the effect of variant genotypes on the serum concentration of CDK4 enzyme and consequently, on the occurrence of ...
Dalya Shakir Al-owaidi
doaj   +1 more source

Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line

Cancer Cell International, 2003
Background One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell cycle progression.
Klover Peter, Messing Edward M, Sowden Mark P, Reeder Jay E, Villa-Moruzzi Emma, Ludlow John W   +5 more
doaj   +1 more source

The expression of retinoblastoma tumor suppressor protein in oral cancers and precancers: A clinicopathological study

Dental Research Journal, 2015
Background: The role of retinoblastoma (Rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including ...
Sunila Thomas, Anita Balan, Prabha Balaram   +2 more
doaj   +1 more source