Retinoblastoma protein: Combating algal bloom [PDF]
Current Biology, 2001 The discovery of a homolog of the retinoblastoma protein (Rb) in a single-celled eukaryote--the alga Chlamydomonas--promises new and surprising insights into Rb's function in cell-cycle regulation.
Cross, Frederick R, Roberts, James M
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Transcriptional inhibition by the retinoblastoma protein
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993 Abstract The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphorylated form is able to interact
Fattaey, A, Helin, K, Harlow, E
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Expression of multidrug resistance proteins in retinoblastoma [PDF]
International Journal of Ophthalmology, 2017 AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or ...
Swati Shukla +8 more
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The retinoblastoma protein modulates Tbx2 functional specificity [PDF]
, 2010 Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness.
Colin R. Goding +14 more
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Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases
Molecules, 2018 Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited ...
Lakshmi Dhevi Nagarajha Selvan +12 more
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Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]
, 2011 Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu +14 more
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Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase
Stem Cell Research, 2018 The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors.
Jian Tu +10 more
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eLife, 2013 Cachexia, a condition that kills about one-fifth of cancer patients, may be linked to Rb—a protein that is already linked to various cancers—moving from the cell nucleus to the cytoplasm.
Giulio Cossu +2 more
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p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]
, 2005 In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique +15 more
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Expression of MMP-14 and CD44 associated with proliferation of retinoblastoma cells
Medicine Science, 2019 Retinoblastoma is a the most common primary intraocular malignant tumor in childhood. The eexpressions of CD44 and MMP-14 and Their role in proliferation and migration cells appear crucial for retinoblastoma invasion.
Hendrian D. Soebagjo +4 more
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