Results 11 to 20 of about 50,847 (238)

Transcriptional inhibition by the retinoblastoma protein [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphorylated form is able to interact
Fattaey, A, Helin, K, Harlow, E
openaire   +4 more sources

Retinoblastoma protein: Combating algal bloom [PDF]

Current Biology, 2001
The discovery of a homolog of the retinoblastoma protein (Rb) in a single-celled eukaryote--the alga Chlamydomonas--promises new and surprising insights into Rb's function in cell-cycle regulation.
Cross, Frederick R, Roberts, James M
openaire   +4 more sources

Expression of multidrug resistance proteins in retinoblastoma [PDF]

International Journal of Ophthalmology, 2017
AIM: To elucidate the mechanism of multidrug resistance in retinoblastoma, and to acquire more insights into in vivo drug resistance. METHODS: Three anticancer drug resistant Y79 human RB cells were generated against vincristine, etoposide or ...
Swati Shukla, Arpna Srivastava, Sunil Kumar, Usha Singh, Sandeep Goswami, Bhavna Chawla, Mandeep Singh Bajaj, Seema Kashyap, Jasbir Kaur   +8 more
doaj   +3 more sources

The retinoblastoma protein modulates Tbx2 functional specificity [PDF]

, 2010
Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness.
Colin R. Goding, Goding, CR, Heather M. Shaw, Sascha Ott, Keith W. Vance, Vance, KW, Shaw, HM, Mercedes Rodriguez, Ott, S, Rodriguez, Mercedes, Goding, Colin R., Ott, Sascha, Shaw, Heather M., Rodriguez, M, Vance, Keith W.   +14 more
core   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Protein-protein interaction in retinoblastoma [PDF]

, 2019
Protein-protein interaction in retinoblastomaThe most common primary intraocular malignancy in children is retinoblastoma. Retinoblastoma has a prevalence of 2% of all cancers diagnosed in children younger than 15. 3 out of 4 children have the disease in
Sarah Hajighadimi (5959262), Rosalind Silverman (5253824), Lorelei Silverman (5205368)   +2 more
core   +1 more source

Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases

Molecules, 2018
Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier studies on retinoblastoma have concentrated on the identification of key players in the disease and have not provided information on activated/inhibited ...
Lakshmi Dhevi Nagarajha Selvan, Ravikanth Danda, Anil K. Madugundu, Vinuth N. Puttamallesh, Gajanan J. Sathe, Uma Maheswari Krishnan, Vikas Khetan, Pukhraj Rishi, Thottethodi Subrahmanya Keshava Prasad, Akhilesh Pandey, Subramanian Krishnakumar, Harsha Gowda, Sailaja V. Elchuri   +12 more
doaj   +1 more source

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu, Bruce, Gareth, Bruce Gareth, Liu, Yule, Liu Yule, Gareth Bruce, Nongnong Shi, Gu, Mei, Hong, Yiguo, Shi Nongnong, Yiguo Hong, Gu Mei, Shi, Nongnong, Hong Yiguo, Mei Gu   +14 more
core   +1 more source

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase

Stem Cell Research, 2018
The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors.
Jian Tu, Zijun Huo, Mo Liu, Donghui Wang, An Xu, Ruoji Zhou, Dandan Zhu, Julian Gingold, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee   +10 more
doaj   +1 more source

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]

, 2015
TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Dunbar, Donald R, Harrison, David J, Sheahan, Sharon, Bellamy, Christopher O, Prost, Sandrine   +4 more
core   +1 more source