Results 41 to 50 of about 1,248,667 (261)

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]

, 2006
Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Popp, Oliver, Nalabothula, Narasimharao, Gil-Parrado, S., Jochum, M., Ghosh, M., Machleidt, W., Machleidt, Werner, Ghosh, Madhumita, Gil-Parrado, Shirley, Holak, Tad A., Joy, J., Joy, Joma, Holak, T. A., Jochum, Marianne, Popp, O., Nalabothula, N.   +15 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An investigation of emerin and nuclear lamins: : Interactions, distribution, and role in cell cycle regulation, in cells derived from EDMD patients. [PDF]

, 2002
Emery Dreifuss muscular dystrophy (EDMD) is caused by mutations either in the gene encoding emerin or in the gene encoding A-type lamins (lamins A and C).
Maria, Choleza
core  

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. [PDF]

, 2007
BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was
Reina Hashimoto, Heck, Margarete M.S., Hashimoto, Reina, Sherkow, Jake, Sharron Vass, Heck, MM, Vass, Sharron, Hashimoto, R, Hashimoto Reina, Yamaguchi Masamitsu, Crevel, Gilles, Cotterill, S, Yamaguchi, M, Heck, Margarete M. S., Vass Sharron, Heck Margarete M.S., Sherkow Jake, Sherkow, Jacob S., Yamaguchi, Masamitsu, Sherkow, J, Cotterill Sue, Crevel Gilles, Margarete M S Heck, Crevel, G, Cotterill, Sue, Vass, S, Gilles Crevel, Margarete M.S. Heck, Jake Sherkow, Sue Cotterill, Masamitsu Yamaguchi   +30 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R; id_orcid, Keith R. Matthews   +1 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Rab11-FIP3 is a cell cycle-regulated phosphoprotein [PDF]

, 2012
<b>BACKGROUND:</b> Rab11 and its effector molecule, Rab11-FIP3 (FIP3), associate with recycling endosomes and traffic into the furrow and midbody of cells during cytokinesis.
Xinzi Yu, Simon, G, Glenn Simon, Prekeris, R., Simon, G., Matheson Johanne, Miller, MC, Collins, L.L., Miller, M Clare, Otani Tetsuhisa, Rytis Prekeris, M Clare Miller, Hayashi, S, Yu Xinzi, Prekeris Rytis, Yu, X, Otani, Tetsuhisa, Gould, Gwyn W, Matheson, J., Prekeris, R, Shigeo Hayashi, Gould, GW, Louise L Collins, Miller, M.C., Wu, C., Collins, LL, Christine Wu, Hayashi, Shigeo, Collins Louise L, Hayashi Shigeo, Simon, Glenn, Yu, Xinzi, Miller M Clare, Simon Glenn, Otani, T, Matheson, Johanne, Yu, X., Gould, G.W., Wu, Christine, Collins, Louise L, Gwyn W Gould, Tetsuhisa Otani, Wu, C, Johanne Matheson, Otani, T., Hayashi, S., Prekeris, Rytis, Wu Christine, Matheson, J, Gould Gwyn W   +49 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source